Abstract:
:Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ25-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer's disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex, medial septum and hippocampus). These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Huang GB,Zhao T,Muna SS,Jin HM,Park JI,Jo KS,Lee BH,Chae SW,Kim SY,Park SH,Park EO,Choi EK,Chung YCdoi
10.3969/j.issn.1673-5374.2013.12.001subject
Has Abstractpub_date
2013-04-25 00:00:00pages
1061-70issue
12eissn
1673-5374issn
1876-7958pii
NRR-8-1061journal_volume
8pub_type
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