Abstract:
:The present study quantitatively analyzed intraspinal cerebrospinal fluid flow patterns in 19 normal adults using fast cine phase-contrast magnetic resonance imaging. Results showed increased downward flow velocity and volume compared with upward flow, and the average downward flow volume of intraspinal cerebrospinal fluid decreased from top to bottom at different intervertebral disc levels. Upward and downward cerebrospinal fluid flow velocity reached a peak at the thoracic intraspinal anterior region, and velocity reached a minimum at the posterior region. Overall measurements revealed that mean upward and downward flow volume positively correlated with the subarachnoid area. Upward peak flow velocity and volume positively correlated with spinal anteroposterior diameter. However, downward peak flow velocity and volume exhibited a negative correlation with spinal anteroposterior diameter. Further flow measurements showed that flow velocity in upward and downward directions was associated with subarachnoid anteroposterior diameter, respectively. The present experimental results showed that cerebrospinal fluid flow velocity and volume varied at different intraspinal regions and were affected by subarachnoid space area and anteroposterior diameter size.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Yan L,Liu H,Shang Hdoi
10.3969/j.issn.1673-5374.2012.15.007subject
Has Abstractpub_date
2012-05-25 00:00:00pages
1164-9issue
15eissn
1673-5374issn
1876-7958pii
NRR-7-1164journal_volume
7pub_type
杂志文章abstract::Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...
journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2012.09.004
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abstract::Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation r...
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.241471
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journal_title:Neural regeneration research
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更新日期:2017-01-01 00:00:00
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