Abstract：
:This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunction and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage (15 days to 11.5 weeks) and 15 age-matched healthy participants. A resting-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely potential targets for the neural regeneration of subacute ischemic stroke patients.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Wu P,Zeng F,Li YX,Yu BL,Qiu LH,Qin W,Li J,Zhou YM,Liang FRdoi
10.4103/1673-5374.156977subject
Has Abstractpub_date
2015-05-01 00:00:00pages
760-5issue
5eissn
1673-5374issn
1876-7958pii
NRR-10-760journal_volume
10pub_type
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.16.001
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.12.001
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journal_title：Neural regeneration research
pub_type： 杂志文章
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.221168
更新日期：2017-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.31.001
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journal_title：Neural regeneration research
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
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更新日期：2012-08-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.11.002
更新日期：2013-04-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
abstract：:Chalcone is a plant metabolite widely found in fruits, vegetables, spices and tea, and has anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidation activities, as well as many other pharmacological and biological effects. Our team has shown that its analogs have antioxidant activity, and oxida...
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pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2012-01-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.19.003
更新日期：2012-07-05 00:00:00
abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
