Abstract:
:At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang Z,Zhang T,Dong Kdoi
10.3969/j.issn.1673-5374.2012.12.001subject
Has Abstractpub_date
2012-04-25 00:00:00pages
885-90issue
12eissn
1673-5374issn
1876-7958pii
NRR-7-885journal_volume
7pub_type
杂志文章abstract::In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.155433
更新日期:2015-04-01 00:00:00
abstract::Spinal cord injury is a major cause of disability with devastating neurological outcomes and limited therapeutic opportunities, even though there are thousands of publications on spinal cord injury annually. There are two major types of spinal cord injury, transaction of the spinal cord and spinal cord contusion. Both...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.131591
更新日期:2014-04-15 00:00:00
abstract::Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.147929
更新日期:2014-12-01 00:00:00
abstract::The present study showed that the latency of rats moving on a vertical grid was significantly prolonged, and the number of rats sliding down from the declined plane was increased remarkably, in rotenone-induced Parkinson's disease model rats compared with control rats. The moving latency recovered to normal levels, bu...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.05.001
更新日期:2012-02-15 00:00:00
abstract::Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are me...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.249215
更新日期:2019-06-01 00:00:00
abstract::Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.268903
更新日期:2020-05-01 00:00:00
abstract::Following spinal cord ischemia/reperfusion injury, an endogenous damage system is immediately activated and participates in a cascade reaction. It is difficult to interpret dynamic changes in these pathways, but the examination of the transcriptome may provide some information. The transcriptome reflects highly dynami...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.179067
更新日期:2016-03-01 00:00:00
abstract::Acrylamide has been shown to be neurotoxic. Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear. In this study, dibutyryl-cyclic adenosine monophosphate-induced mature human neuroblastoma (NB-1) cells were exposed with 0-100 μg/mL...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.286976
更新日期:2021-01-01 00:00:00
abstract::In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent cla...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.293132
更新日期:2021-04-01 00:00:00
abstract::A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ische...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.11.006
更新日期:2012-04-15 00:00:00
abstract::[This corrects the article DOI: 10.4103/1673-5374.245480]. ...
journal_title:Neural regeneration research
pub_type: 杂志文章,已发布勘误
doi:10.4103/1673-5374.250633
更新日期:2019-06-01 00:00:00
abstract::Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.268895
更新日期:2020-05-01 00:00:00
abstract::Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve tran...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.247473
更新日期:2019-04-01 00:00:00
abstract::After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.133150
更新日期:2014-05-01 00:00:00
abstract::The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.306095
更新日期:2021-09-01 00:00:00
abstract::Human umbilical cord mesenchymal stem cells, incorporated into an amnion carrier tubes, were assessed for nerve regeneration potential in a rat nerve defect model. Damaged nerves were exposed to human amnion carriers containing either human umbilical cord mesenchymal stem cell (cell transplantation group) or saline (c...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.23.002
更新日期:2012-08-15 00:00:00
abstract::A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeos...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.226379
更新日期:2018-02-01 00:00:00
abstract::The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.244798
更新日期:2019-02-01 00:00:00
abstract::Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.306061
更新日期:2021-09-01 00:00:00
abstract::End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps, compared to repairs with a graft. However, grafts are typically used to enable a tension-free repair for moderate to large gaps, as excessive tension can cause repairs to fail and catastrophically impede recover...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.251338
更新日期:2019-07-01 00:00:00
abstract::Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.162755
更新日期:2015-08-01 00:00:00
abstract::Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.228758
更新日期:2018-03-01 00:00:00
abstract::Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low l...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145337
更新日期:2014-11-01 00:00:00
abstract::For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticit...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.280302
更新日期:2020-10-01 00:00:00
abstract::The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus a...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145358
更新日期:2014-11-01 00:00:00
abstract::Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Therefore, we assumed that baicalin would suppress co-listin sulfate-induced neuronal apoptosis. PC12 cells exposed to colistin sulfate (62.5-500 μg/mL) for 24 hours resu...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.28.001
更新日期:2013-10-05 00:00:00
abstract::Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right mi...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.241463
更新日期:2018-12-01 00:00:00
abstract::Clinical studies have shown that hyperbaric oxygen therapy improves motor function in patients with spinal cord injury. In the present study, we explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. We established an acute sp...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.147951
更新日期:2014-12-15 00:00:00
abstract:Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.266915
更新日期:2020-04-01 00:00:00
abstract::Mecobalamin, a form of vitamin B12 containing a central metal element (cobalt), is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve c...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145379
更新日期:2014-11-15 00:00:00