Abstract:
:The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus and brain stem to identify the myelin debris. Seven days after diffuse axonal injury, many Oil Red O-stained particles were observed in the cerebral cortex, hippocampus and brain stem. In the cerebral cortex and hippocampus, the amount of myelin debris peaked at 14 days after injury, and decreased significantly at 28 days. In the brain stem, the amount of myelin debris peaked at 7 days after injury, and decreased significantly at 14 and 28 days. In the cortex and hippocampus, some myelin debris could still be observed at 28 days after diffuse axonal injury. Our findings suggest that myelin debris may persist in the rat central nervous system after diffuse axonal injury, which would hinder recovery.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Wen L,Xu J,Zhan T,Wang H,Huang X,Liu W,Yang X,Zhan Rdoi
10.4103/1673-5374.145358subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1902-6issue
21eissn
1673-5374issn
1876-7958pii
NRR-9-1902journal_volume
9pub_type
杂志文章abstract::Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.197135
更新日期:2016-12-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.22.001
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abstract::In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...
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pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.22.003
更新日期:2012-08-05 00:00:00
abstract::[This corrects the article on p. 1386 in vol. 10, PMID: 26604888.]. ...
journal_title:Neural regeneration research
pub_type: 已发布勘误
doi:10.4103/1673-5374.187069
更新日期:2016-07-01 00:00:00
abstract::Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models of deafness. However, to the best of our knowledge, there is no report on the establishment of a rat deafness model through the combined application of aminoglycosides and loop diuretics. The aim of this study was to use single...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.153704
更新日期:2015-10-01 00:00:00
abstract::Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.162755
更新日期:2015-08-01 00:00:00
abstract::Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days ...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.219025
更新日期:2017-11-01 00:00:00
abstract::An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Ep...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.21.002
更新日期:2012-07-25 00:00:00
abstract::Alzheimer's disease is the leading cause of dementia. Its increased prevalence in developed countries, due to the sharp rise in ageing populations, presents one of the costliest challenges to modern medicine. In order to find disease-modifying therapies to confront this challenge, a more complete understanding of the ...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.272571
更新日期:2020-07-01 00:00:00
abstract::Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.301024
更新日期:2021-07-01 00:00:00
abstract::Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.139454
更新日期:2014-08-01 00:00:00
abstract::Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicit...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.128218
更新日期:2014-02-01 00:00:00
abstract::Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer's disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this review, we evaluated the ways in which modern imaging techniques such a...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.286957
更新日期:2021-01-01 00:00:00
abstract::New Zealand rabbits were randomly divided into an ischemia group (occlusion of the abdominal aorta for 60 minutes), an ischemia-reperfusion group (occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group. Two-dimensional gel electrophoresis detected 49 differentiall...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.20.002
更新日期:2012-07-15 00:00:00
abstract:Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.266064
更新日期:2020-03-01 00:00:00
abstract::This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence ...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.230303
更新日期:2018-04-01 00:00:00
abstract::The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.245472
更新日期:2019-03-01 00:00:00
abstract::As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute isch...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.19.001
更新日期:2013-07-05 00:00:00
abstract::LIM homeobox transcription factor 1a (Lmx1a) has the capacity to initiate the development program of neuronal cells and promote the differentiation of embryonic stem cells into dopaminergic neurons. In this study, rhesus adipose stem cells were infected with recombinant adenovirus carrying the Lmx1a gene and co-cultur...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.34.001
更新日期:2012-12-05 00:00:00
abstract::Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effect. Spinal cord inju...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.208591
更新日期:2017-06-01 00:00:00
abstract::Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.221168
更新日期:2017-12-01 00:00:00
abstract::Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.206633
更新日期:2017-05-01 00:00:00
abstract::The electrical excitability of neural networks is influenced by different environmental factors. Effective and simple methods are required to objectively and quantitatively evaluate the influence of such factors, including variations in temperature and pharmaceutical dosage. The aim of this paper was to introduce 'the...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.233446
更新日期:2018-06-01 00:00:00
abstract::Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In t...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.131577
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.130094
更新日期:2014-03-15 00:00:00
abstract::Growth arrest-specific 5 (GAS5) is an anti-oncogene that has been extensively studied in tumors. However, research on GAS5 in the context of nervous system disease is rare at present. This study aimed to investigate the role of the long non-coding RNA GAS5 in rat pheochromocytoma cells (PC12 cells). GAS5-overexpressin...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.262592
更新日期:2019-12-01 00:00:00
abstract::The reconstruction of nerve continuity after traumatic nerve injury is the gold standard in hand surgery. Immediate, tension-free, end-to-end nerve suture ensures the best prognosis. The recovery is mostly promising; however, in a few cases, insufficient outcomes in motor or sensory function are observed. Intra- and e...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.297081
更新日期:2021-05-01 00:00:00
abstract::Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation r...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.276359
更新日期:2020-09-01 00:00:00
abstract::Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to gene...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.23.001
更新日期:2013-08-15 00:00:00
abstract::Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.29.001
更新日期:2013-10-15 00:00:00