DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after 125I radioactive seed implantation.

Abstract:

:Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Radioactive 125I seeds to irradiate 90% of the spinal cord tissue at doses of 40-100 Gy (D90) were implanted in rabbits at T10 to induce radiation injury, and we evaluated their safety for use in the spinal cord. Diffusion tensor imaging showed that with increased D90, the apparent diffusion coefficient and fractional anisotropy values were increased. Moreover, pathological damage of neurons and microvessels in the gray matter and white matter was aggravated. At 2 months after implantation, obvious pathological injury was visible in the spinal cords of each group. Magnetic resonance diffusion tensor imaging revealed the radiation injury to the spinal cord, and we quantified the degree of spinal cord injury through apparent diffusion coefficient and fractional anisotropy.

journal_name

Neural Regen Res

authors

Cao X,Fang L,Cui CY,Gao S,Wang TW

doi

10.4103/1673-5374.228758

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

528-535

issue

3

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2018_13_3_528_228758

journal_volume

13

pub_type

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