The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury.

abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...

journal_title：Neural regeneration research

authors： Colpo GD,Stimming EF,Rocha NP,Teixeira AL

更新日期：2017-09-01 00:00:00

abstract：:The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an activ...

journal_title：Neural regeneration research

authors： Balusu S,Brkic M,Libert C,Vandenbroucke RE

更新日期：2016-04-01 00:00:00

abstract：:In contrast to astrocytes in mammals, fish astrocytes promote axon regeneration after brain injury and actively participate in the regeneration process. Neurolin, a regeneration-associated, Zn8-labeled protein, is involved in the repair of damaged optic nerve in goldfish. At 1 week after unilateral eye injury, the exp...

journal_title：Neural regeneration research

authors： Pushchina EV,Varaksin AA

更新日期：2019-01-01 00:00:00

abstract：:Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion inj...

journal_title：Neural regeneration research

authors： Zhang L,Gan W,An G

更新日期：2012-12-25 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all the secondary injury mechanisms, the inflammatory response is the major contributor and results in expansion of the les...

journal_title：Neural regeneration research

authors： Zhou X,He X,Ren Y

更新日期：2014-10-15 00:00:00

abstract：:Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hy...

journal_title：Neural regeneration research

authors： Biazar E,Keshel SH,Pouya M

更新日期：2013-09-25 00:00:00

abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...

journal_title：Neural regeneration research

authors： Feng Z,Zhong YJ,Wang L,Wei TQ

更新日期：2015-04-01 00:00:00

abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

journal_title：Neural regeneration research

authors： Wang X,Wu H,Xue G,Hou Y

更新日期：2012-09-05 00:00:00

abstract：:Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following nervous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting spec...

journal_title：Neural regeneration research

authors： Struzyna LA,Harris JP,Katiyar KS,Chen HI,Cullen DK

更新日期：2015-05-01 00:00:00

abstract：:Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold mater...

journal_title：Neural regeneration research

authors： Zhang PX,Han N,Kou YH,Zhu QT,Liu XL,Quan DP,Chen JG,Jiang BG

更新日期：2019-01-01 00:00:00

abstract：:Septic encephalopathy is a frequent complication of sepsis, but there are few studies examining the role of microRNAs (miRs) in its pathogenesis. In this study, a miR-219 mimic was transfected into rat hippocampal neurons to model miR-219 overexpression. A protective effect of miR-219 was observed for glutamate-induce...

journal_title：Neural regeneration research

authors： Wang T,Cai Q,Yang WJ,Fan HH,Yi JF,Xu F

更新日期：2018-07-01 00:00:00

abstract：:A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ische...

journal_title：Neural regeneration research

authors： Xiao F,Xiong L,Wang Q,Zhou L,Zhou Q

更新日期：2012-04-15 00:00:00

abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...

journal_title：Neural regeneration research

authors： Apara A,Goldberg JL

更新日期：2014-08-01 00:00:00

abstract：:Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In t...

journal_title：Neural regeneration research

authors： Liu J,Li J,Yang Y,Wang X,Zhang Z,Zhang L

更新日期：2014-04-01 00:00:00

abstract：:Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...

journal_title：Neural regeneration research

authors： Ding S

更新日期：2014-12-01 00:00:00

abstract：:Sterile inflammatory processes are essential for the maintenance of central nervous system homeostasis, but they also contribute to various neurological disorders, including neurotrauma, stroke, and demyelinating or neurodegenerative diseases. Immune mechanisms in the central nervous system and periphery are regulated...

journal_title：Neural regeneration research

authors： Klegeris A

更新日期：2021-03-01 00:00:00

abstract：:Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) path...

journal_title：Neural regeneration research

authors： Wu CX,Feng YH,Yang L,Zhan ZL,Xu XH,Hu XY,Zhu ZH,Zhou GP

更新日期：2018-09-01 00:00:00

abstract：:In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent cla...

journal_title：Neural regeneration research

authors： Qin L,Li J

更新日期：2021-04-01 00:00:00

abstract：:Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...

journal_title：Neural regeneration research

authors： Zhao YD,Zhang QB,Chen H,Fei XF,Shen YT,Ji XY,Ma JW,Wang AD,Dong J,Lan Q,Huang Q

更新日期：2017-11-01 00:00:00

abstract：:Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...

journal_title：Neural regeneration research

authors： Kou YH,Zhang PX,Wang YH,Chen B,Han N,Xue F,Zhang HB,Yin XF,Jiang BG

更新日期：2015-01-01 00:00:00

abstract：:The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for con...

journal_title：Neural regeneration research

authors： Ohtake Y,Hayat U,Li S

更新日期：2015-09-01 00:00:00

abstract：:Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer's disease. Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture. Rat models of Alzheimer's disease were established by injecting amyloid beta 1-42 (Aβ1-42) into the bilateral lateral ventricles. Electroacup...

journal_title：Neural regeneration research

authors： Yu CC,Wang Y,Shen F,Kong LH,Wang YW,Zhou H,Tang L

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

journal_title：Neural regeneration research

authors： Lee A,Ziouzenkova O

更新日期：2019-02-01 00:00:00

abstract：:Severe edema in the endoneurium can occur after non-freezing cold injury to the peripheral nerve, which suggests damage to the blood-nerve barrier. To determine the effects of cold injury on the blood-nerve barrier, the sciatic nerve on one side of Wistar rats was treated with low temperatures (3-5°C) for 2 hours. The...

journal_title：Neural regeneration research

authors： Li H,Jia JP,Xu M,Zhang L

更新日期：2015-03-01 00:00:00

abstract：:Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin (8-(β-D-Glucopyranosyl-7-h...

journal_title：Neural regeneration research

authors： Wu M,Zhao G,Yang X,Peng C,Zhao J,Liu J,Li R,Gao Z

更新日期：2014-03-15 00:00:00

abstract：:Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rode...

journal_title：Neural regeneration research

authors： Jure I,Labombarda F

更新日期：2017-07-01 00:00:00

abstract：:In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham con...

journal_title：Neural regeneration research

authors： Yoo DY,Yoo KY,Park JH,Kwon HJ,Jung HY,Kim JW,Choi GM,Moon SM,Kim DW,Yoon YS,Won MH,Hwang IK

更新日期：2016-06-01 00:00:00

abstract：:The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sou...

journal_title：Neural regeneration research

authors： Wang Y,Wang N,Wang D,Jia J,Liu J,Xie Y,Wen X,Li X

更新日期：2014-02-15 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare system...

journal_title：Neural regeneration research

authors： Ferreira S,Raimundo AF,Menezes R,Martins IC

更新日期：2021-06-01 00:00:00