Dynamic reactive astrocytes after focal ischemia.

abstract：:Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we induced a photochemical mode...

journal_title：Neural regeneration research

authors： Li S,Zhang Y,Shao G,Yang M,Niu J,Lv G,Ji X

更新日期：2013-11-05 00:00:00

abstract：:Cattle encephalon glycoside and ignotin (CEGI) injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules, such as polypeptides, monosialotetrahexosyl ganglioside (GM-1), free amino acids, hypoxanthine and carnosine. CEGI has been approved by the Chinese State Food and Drug ...

journal_title：Neural regeneration research

authors： Zhong J,Li RW,Wang J,Wang Y,Ge HF,Xian JS,Feng H,Tan L

更新日期：2021-02-01 00:00:00

abstract：:End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps, compared to repairs with a graft. However, grafts are typically used to enable a tension-free repair for moderate to large gaps, as excessive tension can cause repairs to fail and catastrophically impede recover...

journal_title：Neural regeneration research

authors： Howarth HM,Alaziz T,Nicolds B,O'Connor S,Shah SB

更新日期：2019-07-01 00:00:00

abstract：:The reconstruction of nerve continuity after traumatic nerve injury is the gold standard in hand surgery. Immediate, tension-free, end-to-end nerve suture ensures the best prognosis. The recovery is mostly promising; however, in a few cases, insufficient outcomes in motor or sensory function are observed. Intra- and e...

journal_title：Neural regeneration research

authors： Krzesniak NE,Sarnowska A,Figiel-Dabrowska A,Osiak K,Domanska-Janik K,Noszczyk BH

更新日期：2021-05-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmiss...

journal_title：Neural regeneration research

authors： Venigalla M,Gyengesi E,Münch G

更新日期：2015-08-01 00:00:00

abstract：Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...

journal_title：Neural regeneration research

authors： Qian K,Xu TY,Wang X,Ma T,Zhang KX,Yang K,Qian TD,Shi J,Li LX,Wang Z

更新日期：2020-04-01 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：:Indirubin-3'-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. Here, we found that indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), an...

journal_title：Neural regeneration research

authors： Zhang SG,Wang XS,Zhang YD,Di Q,Shi JP,Qian M,Xu LG,Lin XJ,Lu J

更新日期：2016-06-01 00:00:00

abstract：:Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were trea...

journal_title：Neural regeneration research

authors： Gao QS,Zhang YH,Xue H,Wu ZY,Li C,Zhao P

更新日期：2021-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare system...

journal_title：Neural regeneration research

authors： Ferreira S,Raimundo AF,Menezes R,Martins IC

更新日期：2021-06-01 00:00:00

abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...

journal_title：Neural regeneration research

authors： Apara A,Goldberg JL

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases. DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their...

journal_title：Neural regeneration research

authors： Tian G,Zhou J,Wang J,Xu B,Li L,Zhu F,Han J,Li J,Zhang S,Luo X

更新日期：2012-09-05 00:00:00

abstract：:This study explored protective effects of Houshiheisan and its compound prescription of wind-dispelling drugs and deficiency-nourishing drugs on cerebral ischemia in terms of astrocyte activation and inflammatory factor expression. Results suggested that Houshiheisan lessened neuronal degeneration in the corpus striat...

journal_title：Neural regeneration research

authors： Zhang Q,Zhao H,Wang L,Zhang Q,Wang H

更新日期：2012-08-25 00:00:00

abstract：:Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

journal_title：Neural regeneration research

authors： Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

更新日期：2016-12-01 00:00:00

abstract：:In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent cla...

journal_title：Neural regeneration research

authors： Qin L,Li J

更新日期：2021-04-01 00:00:00

abstract：:This study investigated the effects of small interfering RNA (siRNA)-mediated silencing of chemokine receptor 4 (CXCR4) on the invasion capacity of human neuroblastoma cell line SH-SY5Y in vitro. Three siRNAs targeting CXCR4 were chemically synthesized and individually transfected into SH-SY5Y cells. Expression of CXC...

journal_title：Neural regeneration research

authors： Chen X,Zhu Y,Han L,Lu H,Hao X,Dong Q

更新日期：2014-05-15 00:00:00

abstract：:Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation...

journal_title：Neural regeneration research

authors： Zhang BY,Chang PY,Zhu QS,Zhu YH,Saijilafu.

更新日期：2020-09-01 00:00:00

abstract：:The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil(®) (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressu...

journal_title：Neural regeneration research

authors： Liu H,Ni Z,Chen Y,Wang D,Qi Y,Zhang Q,Wang S

更新日期：2012-04-05 00:00:00

abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...

journal_title：Neural regeneration research

authors： Liu JH,Li XK,Chen ZB,Cai Q,Wang L,Ye YH,Chen QX

更新日期：2017-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors su...

journal_title：Neural regeneration research

authors： Mathis S,Couratier P,Julian A,Corcia P,Le Masson G

更新日期：2017-02-01 00:00:00

abstract：:Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brai...

journal_title：Neural regeneration research

authors： Zhao Y,Li J,Tang Q,Gao J,Chen C,Jing L,Zhang P,Li S

更新日期：2014-03-01 00:00:00

abstract：:Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...

journal_title：Neural regeneration research

authors： Zhao YD,Zhang QB,Chen H,Fei XF,Shen YT,Ji XY,Ma JW,Wang AD,Dong J,Lan Q,Huang Q

更新日期：2017-11-01 00:00:00

abstract：:Fimbria-fornix transection induces both exogenous and endogenous neural stem cells to differentiate into neurons in the hippocampus. This indicates that the denervated hippocampus provides an environment for neuronal differentiation of neural stem cells. However, the pathways and mechanisms in this process are still u...

journal_title：Neural regeneration research

authors： Zhang L,Han X,Cheng X,Tan XF,Zhao HY,Zhang XH

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage a...

journal_title：Neural regeneration research

authors： Lara-Celador I,Goñi-de-Cerio F,Alvarez A,Hilario E

更新日期：2013-03-15 00:00:00

abstract：:Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...

journal_title：Neural regeneration research

authors： Pan B,Shi ZJ,Yan JY,Li JH,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the ri...

journal_title：Neural regeneration research

authors： Du L,Yang M,Wan L,Wang XH,Li ST

更新日期：2016-10-01 00:00:00

abstract：:Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role ...

journal_title：Neural regeneration research

authors： Peyvandi AA,Roozbahany NA,Peyvandi H,Abbaszadeh HA,Majdinasab N,Faridan M,Niknazar S

更新日期：2018-01-01 00:00:00

abstract：:The Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of ...

journal_title：Neural regeneration research

authors： Cai X,Yang L,Zhou J,Zhu D,Guo Q,Chen Z,Chen S,Zhou L

更新日期：2013-02-25 00:00:00

abstract：:After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides ...

journal_title：Neural regeneration research

authors： Lu H,Lei X

更新日期：2014-05-01 00:00:00