Abstract:
:Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Therefore, we assumed that baicalin would suppress co-listin sulfate-induced neuronal apoptosis. PC12 cells exposed to colistin sulfate (62.5-500 μg/mL) for 24 hours resulted in PC12 cell apoptosis. In addition, caspase-3 activity, lactate dehydrogenase level and free radical content increased in a dose-dependent manner. Subsequently, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, tate dehydrogenase level and free radical content decreased. Results indicated that baicalin inhi-bited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Jiang H,Lv P,Li J,Wang H,Zhou T,Liu Y,Lin Wdoi
10.3969/j.issn.1673-5374.2013.28.001subject
Has Abstractpub_date
2013-10-05 00:00:00pages
2597-604issue
28eissn
1673-5374issn
1876-7958pii
NRR-8-2597journal_volume
8pub_type
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