Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury.

Abstract:

:A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.

journal_name

Neural Regen Res

authors

Xiao F,Xiong L,Wang Q,Zhou L,Zhou Q

doi

10.3969/j.issn.1673-5374.2012.11.006

subject

Has Abstract

pub_date

2012-04-15 00:00:00

pages

833-6

issue

11

eissn

1673-5374

issn

1876-7958

pii

NRR-7-833

journal_volume

7

pub_type

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