Human amnion tissue injected with human umbilical cord mesenchymal stem cells repairs damaged sciatic nerves in rats.

abstract：:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...

journal_title：Neural regeneration research

authors： Ren C,Ji YQ,Liu H,Wang Z,Wang JH,Zhang CY,Guan LN,Yin PY

更新日期：2019-07-01 00:00:00

abstract：:As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in th...

journal_title：Neural regeneration research

authors： Agatonovic-Kustrin S,Kustrin E,Morton DW

更新日期：2019-03-01 00:00:00

abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

journal_title：Neural regeneration research

authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

更新日期：2016-09-01 00:00:00

abstract：:After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical t...

journal_title：Neural regeneration research

authors： Wang H,Si L,Li X,Deng W,Yang H,Yang Y,Fu Y

更新日期：2012-05-15 00:00:00

abstract：:Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...

journal_title：Neural regeneration research

authors： Zhao JJ,Liu ZW,Wang B,Huang TQ,Guo D,Zhao YL,Song JN

更新日期：2020-04-01 00:00:00

abstract：:Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

journal_title：Neural regeneration research

authors： Shultz RB,Zhong Y

更新日期：2017-05-01 00:00:00

abstract：:Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rode...

journal_title：Neural regeneration research

authors： Jure I,Labombarda F

更新日期：2017-07-01 00:00:00

abstract：:Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelo...

journal_title：Neural regeneration research

authors： Lin E,Long H,Li G,Lei W

更新日期：2013-12-25 00:00:00

abstract：:In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...

journal_title：Neural regeneration research

authors： Yu XH,Wu JX,Chen L,Gu YD

更新日期：2020-07-01 00:00:00

abstract：:The relative frequencies of different subtypes of limb-girdle muscular dystrophies vary widely among different populations. We estimated the percentage of limb-girdle muscular dystrophy subtypes in Chinese people based on 68 patients with limb-girdle muscular dystrophy from the Myology Clinic, Neurology Department, Fi...

journal_title：Neural regeneration research

authors： Mahmood OA,Jiang X,Zhang Q

更新日期：2013-07-15 00:00:00

abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...

journal_title：Neural regeneration research

authors： Yuan LY,He ZY,Li L,Wang YZ

更新日期：2019-03-01 00:00:00

abstract：:Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Therefore, we assumed that baicalin would suppress co-listin sulfate-induced neuronal apoptosis. PC12 cells exposed to colistin sulfate (62.5-500 μg/mL) for 24 hours resu...

journal_title：Neural regeneration research

authors： Jiang H,Lv P,Li J,Wang H,Zhou T,Liu Y,Lin W

更新日期：2013-10-05 00:00:00

abstract：:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

journal_title：Neural regeneration research

authors： Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

更新日期：2021-07-01 00:00:00

abstract：:This study investigated the effects of small interfering RNA (siRNA)-mediated silencing of chemokine receptor 4 (CXCR4) on the invasion capacity of human neuroblastoma cell line SH-SY5Y in vitro. Three siRNAs targeting CXCR4 were chemically synthesized and individually transfected into SH-SY5Y cells. Expression of CXC...

journal_title：Neural regeneration research

authors： Chen X,Zhu Y,Han L,Lu H,Hao X,Dong Q

更新日期：2014-05-15 00:00:00

abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...

journal_title：Neural regeneration research

authors： Pan S,Wan J,Liu S,Zhang S,Xiong H,Zhou J,Xiong W,Yu K,Fu Y

更新日期：2013-06-15 00:00:00

abstract：:In this study, we hypothesized that an increase in integrin αvβ3 and its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning with bilateral common carotid artery occlusion for 5 minutes in C57BL/6J mice. This was followed by isc...

journal_title：Neural regeneration research

authors： Ma XM,Liu M,Liu YY,Ma LL,Jiang Y,Chen XH

更新日期：2016-05-01 00:00:00

abstract：:Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brai...

journal_title：Neural regeneration research

authors： Zhao Y,Li J,Tang Q,Gao J,Chen C,Jing L,Zhang P,Li S

更新日期：2014-03-01 00:00:00

abstract：:Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer's disease cell model. swAPP695-HEK293 cells were treated with 0, 0.5, 1, 2, 5, and 10 μM curcumin for ...

journal_title：Neural regeneration research

authors： Liu HY,Fu X,Li YF,Li XL,Ma ZY,Zhang Y,Gao QC

更新日期：2019-09-01 00:00:00

abstract：:Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in bra...

journal_title：Neural regeneration research

authors： Filosa S,Di Meo F,Crispi S

更新日期：2018-12-01 00:00:00

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...

journal_title：Neural regeneration research

authors： Kou YH,Zhang PX,Wang YH,Chen B,Han N,Xue F,Zhang HB,Yin XF,Jiang BG

更新日期：2015-01-01 00:00:00

abstract：:For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticit...

journal_title：Neural regeneration research

authors： Sabel BA,Gao Y,Antal A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:Injuries to the central or peripheral nervous system frequently cause long-term disabilities because damaged neurons are unable to efficiently self-repair. This inherent deficiency necessitates the need for new treatment options aimed at restoring lost function to patients. Compared to humans, a number of species poss...

journal_title：Neural regeneration research

authors： Teoh JS,Wong MY,Vijayaraghavan T,Neumann B

更新日期：2018-04-01 00:00:00

abstract：:The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

journal_title：Neural regeneration research

authors： Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

更新日期：2016-11-01 00:00:00

abstract：:Endothelial progenitor cells secrete a variety of growth factors that inhibit inflammation, promote angiogenesis and exert neuroprotective effects. Therefore, in this study, we investigated whether endothelial progenitor cell-conditioned medium might have therapeutic effectiveness for the treatment of spinal cord inju...

journal_title：Neural regeneration research

authors： Wang T,Fang X,Yin ZS

更新日期：2018-05-01 00:00:00

abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

journal_title：Neural regeneration research

authors： Jeanneret V,Yepes M

更新日期：2017-03-01 00:00:00

abstract：:Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we us...

journal_title：Neural regeneration research

authors： Yang XM,Chen XH,Lu JF,Zhou CM,Han JY,Chen CH

更新日期：2018-03-01 00:00:00

abstract：:No recommended guidelines currently exist for the therapeutic concentration or dose of botulinum toxin type A (BTXA) injected into the muscle to treat limb spasticity. Therefore, in this randomized controlled trial, we explored the safety and efficacy of two concentrations and two doses of BTXA in the treatment of spa...

journal_title：Neural regeneration research

authors： Li J,Zhang R,Cui BL,Zhang YX,Bai GT,Gao SS,Li WJ

更新日期：2017-09-01 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) is a potential nutrient for nerve repair. However, it is impractical as a therapy because of its limited half-life, rapid clearance, and limited target specificity. To achieve targeted and long-lasting treatment, we investigated the addition of a binding structure by fusing a colla...

journal_title：Neural regeneration research

authors： Li JA,Zhao CF,Li SJ,Zhang J,Li ZH,Zhang Q,Yang XY,Zan CF

更新日期：2018-02-01 00:00:00