Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe.

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare system...

journal_title：Neural regeneration research

authors： Ferreira S,Raimundo AF,Menezes R,Martins IC

更新日期：2021-06-01 00:00:00

abstract：:Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model...

journal_title：Neural regeneration research

authors： Gao BY,Sun CC,Xia GH,Zhou ST,Zhang Y,Mao YR,Liu PL,Zheng Y,Zhao D,Li XT,Xu J,Xu DS,Bai YL

更新日期：2020-11-01 00:00:00

abstract：:Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...

journal_title：Neural regeneration research

authors： Li DW,Zhou FZ,Sun XC,Li SC,Yang JB,Sun HH,Wang AH

更新日期：2019-10-01 00:00:00

abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

journal_title：Neural regeneration research

authors： Jeanneret V,Yepes M

更新日期：2017-03-01 00:00:00

abstract：:An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Ep...

journal_title：Neural regeneration research

authors： Niu S,Kou S,Zhou X,Ding L

更新日期：2012-07-25 00:00:00

abstract：:The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus a...

journal_title：Neural regeneration research

authors： Wen L,Xu J,Zhan T,Wang H,Huang X,Liu W,Yang X,Zhan R

更新日期：2014-11-01 00:00:00

abstract：:Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...

journal_title：Neural regeneration research

authors： Fu PC,Tang RH,Yu ZY,Xie MJ,Wang W,Luo X

更新日期：2018-04-01 00:00:00

abstract：:For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticit...

journal_title：Neural regeneration research

authors： Sabel BA,Gao Y,Antal A

更新日期：2020-10-01 00:00:00

abstract：:Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone II...

journal_title：Neural regeneration research

authors： Yang YD,Yu X,Wang XM,Mu XH,He F

更新日期：2017-02-01 00:00:00

abstract：Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...

journal_title：Neural regeneration research

authors： Xu BP,Yao M,Li ZJ,Tian ZR,Ye J,Wang YJ,Cui XJ

更新日期：2020-03-01 00:00:00

abstract：:In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endot...

journal_title：Neural regeneration research

authors： Wang R,Hao D,Shi W,Pu J,Wang Z

更新日期：2012-03-15 00:00:00

abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...

journal_title：Neural regeneration research

authors： Liu JH,Li XK,Chen ZB,Cai Q,Wang L,Ye YH,Chen QX

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA: INCLUSION CRITERIA:(a) peer-reviewed publ...

journal_title：Neural regeneration research

authors： Mu Y,Li N,Guan L,Wang C,Shang S,Wang Y

更新日期：2012-11-25 00:00:00

abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...

journal_title：Neural regeneration research

authors： Kim J,Im HI,Moon C

更新日期：2018-01-01 00:00:00

abstract：:Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction, the nicotinic acetylcholine receptor. Other varia...

journal_title：Neural regeneration research

authors： Barrantes FJ

更新日期：2021-02-01 00:00:00

abstract：:One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage a...

journal_title：Neural regeneration research

authors： Lara-Celador I,Goñi-de-Cerio F,Alvarez A,Hilario E

更新日期：2013-03-15 00:00:00

abstract：:A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...

journal_title：Neural regeneration research

authors： Kent MR,Kara N,Patton JG

更新日期：2021-02-01 00:00:00

abstract：:There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

journal_title：Neural regeneration research

authors： Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

更新日期：2013-11-25 00:00:00

abstract：:Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to di...

journal_title：Neural regeneration research

authors： Maiese K

更新日期：2016-03-01 00:00:00

abstract：:The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for con...

journal_title：Neural regeneration research

authors： Ohtake Y,Hayat U,Li S

更新日期：2015-09-01 00:00:00

abstract：Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...

journal_title：Neural regeneration research

authors： Qian K,Xu TY,Wang X,Ma T,Zhang KX,Yang K,Qian TD,Shi J,Li LX,Wang Z

更新日期：2020-04-01 00:00:00

abstract：:Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve syst...

journal_title：Neural regeneration research

authors： Wu S,Cao X,He R,Xiong K

更新日期：2012-02-15 00:00:00

abstract：:Severe edema in the endoneurium can occur after non-freezing cold injury to the peripheral nerve, which suggests damage to the blood-nerve barrier. To determine the effects of cold injury on the blood-nerve barrier, the sciatic nerve on one side of Wistar rats was treated with low temperatures (3-5°C) for 2 hours. The...

journal_title：Neural regeneration research

authors： Li H,Jia JP,Xu M,Zhang L

更新日期：2015-03-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all the secondary injury mechanisms, the inflammatory response is the major contributor and results in expansion of the les...

journal_title：Neural regeneration research

authors： Zhou X,He X,Ren Y

更新日期：2014-10-15 00:00:00

abstract：:A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ische...

journal_title：Neural regeneration research

authors： Xiao F,Xiong L,Wang Q,Zhou L,Zhou Q

更新日期：2012-04-15 00:00:00

abstract：:The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

journal_title：Neural regeneration research

authors： Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

更新日期：2016-11-01 00:00:00

abstract：:Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix ...

journal_title：Neural regeneration research

authors： Mu Q,Liu P,Hu X,Gao H,Zheng X,Huang H

更新日期：2014-09-01 00:00:00

abstract：:To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mash1 was no...

journal_title：Neural regeneration research

authors： Ding D,Xu L,Xu H,Li X,Liang Q,Zhao Y,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...

journal_title：Neural regeneration research

authors： Ding S

更新日期：2014-12-01 00:00:00

abstract：:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...

journal_title：Neural regeneration research

authors： Ren C,Ji YQ,Liu H,Wang Z,Wang JH,Zhang CY,Guan LN,Yin PY

更新日期：2019-07-01 00:00:00