Abstract:
:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown. In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were administered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1.33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotrophic factor (BDNF)-immunoreactive cells in the hippocampal CA1 region. rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia. The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA1 region.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang XQ,Li L,Huo JT,Cheng M,Li LHdoi
10.4103/1673-5374.235251subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1384-1389issue
8eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2018_13_8_1384_235251journal_volume
13pub_type
杂志文章abstract::Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix ...
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doi:10.3969/j.issn.1673-5374.2012.25.001
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2012.04.008
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pub_type: 杂志文章
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