The role of autophagy in Parkinson's disease.

abstract：:Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmiss...

journal_title：Neural regeneration research

authors： Venigalla M,Gyengesi E,Münch G

更新日期：2015-08-01 00:00:00

abstract：:Chalcone is a plant metabolite widely found in fruits, vegetables, spices and tea, and has anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidation activities, as well as many other pharmacological and biological effects. Our team has shown that its analogs have antioxidant activity, and oxida...

journal_title：Neural regeneration research

authors： Wang L,Chen HC,Yang X,Tao JJ,Liang G,Wu JZ,Wu WC,Wang Y,Song ZM,Zhang X

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To analyze international research trends in hepatic encephalopathy and examine the role of neuroelectrophysiology and neuroimaging in diagnosis of hepatic encephalopathy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on hepatic encephalopathy published during 2002-2011 retrieved from Web of ...

journal_title：Neural regeneration research

authors： Li N

更新日期：2012-12-05 00:00:00

abstract：:Sterile inflammatory processes are essential for the maintenance of central nervous system homeostasis, but they also contribute to various neurological disorders, including neurotrauma, stroke, and demyelinating or neurodegenerative diseases. Immune mechanisms in the central nervous system and periphery are regulated...

journal_title：Neural regeneration research

authors： Klegeris A

更新日期：2021-03-01 00:00:00

abstract：:The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...

journal_title：Neural regeneration research

authors： Yang B,Wang PB,Mu N,Ma K,Wang S,Yang CY,Huang ZB,Lai Y,Feng H,Yin GF,Chen TN,Hu CS

更新日期：2021-09-01 00:00:00

abstract：:We have previously shown that induction of ketosis by ketogenic diet (KD) conveyed neuroprotection following spinal cord injury in rodent models, however, clinical translation may be limited by the slow raise of ketone levels when applying KD in the acute post-injury period. Thus we investigated the use of exogenous k...

journal_title：Neural regeneration research

authors： Tan BT,Jiang H,Moulson AJ,Wu XL,Wang WC,Liu J,Plunet WT,Tetzlaff W

更新日期：2020-10-01 00:00:00

abstract：:Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...

journal_title：Neural regeneration research

authors： Lin DQ,Cai XY,Wang CH,Yang B,Liang RS

更新日期：2020-05-01 00:00:00

abstract：:The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...

journal_title：Neural regeneration research

authors： Li XJ,Li CK,Wei LY,Lu N,Wang GH,Zhao HG,Li DL

更新日期：2015-06-01 00:00:00

abstract：:Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ25-35 into bi...

journal_title：Neural regeneration research

authors： Huang GB,Zhao T,Muna SS,Jin HM,Park JI,Jo KS,Lee BH,Chae SW,Kim SY,Park SH,Park EO,Choi EK,Chung YC

更新日期：2013-04-25 00:00:00

abstract：:The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for con...

journal_title：Neural regeneration research

authors： Ohtake Y,Hayat U,Li S

更新日期：2015-09-01 00:00:00

abstract：:Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelo...

journal_title：Neural regeneration research

authors： Lin E,Long H,Li G,Lei W

更新日期：2013-12-25 00:00:00

abstract：:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...

journal_title：Neural regeneration research

authors： Ren C,Ji YQ,Liu H,Wang Z,Wang JH,Zhang CY,Guan LN,Yin PY

更新日期：2019-07-01 00:00:00

abstract：:Temporal lobe epilepsy is associated with astrogliosis. Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. This study investigated the presence of Notch1, hairy and enhancer of split-1, and glial fibrillary acidic protei...

journal_title：Neural regeneration research

authors： Liu X,Yang Z,Yin Y,Deng X

更新日期：2014-03-01 00:00:00

abstract：:Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subje...

journal_title：Neural regeneration research

authors： Guo H,Shen X,Xu Y,Yuan J,Zhao D,Hu W

更新日期：2013-05-25 00:00:00

abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...

journal_title：Neural regeneration research

authors： Feng Z,Zhong YJ,Wang L,Wei TQ

更新日期：2015-04-01 00:00:00

abstract：:One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroenceph...

journal_title：Neural regeneration research

authors： Wang W,Fan Z,Zhang Y,Yang Y,Liu Y,Dang X,Song W,Wu Y,Ye J

更新日期：2013-01-25 00:00:00

abstract：:Paired immunoglobulin-like receptor B (PirB) is a functional receptor of myelin-associated inhibitors for axonal regeneration and synaptic plasticity in the central nervous system, and thus suppresses nerve regeneration. The regulatory effect of PirB on injured nerves has received a lot of attention. To better underst...

journal_title：Neural regeneration research

authors： Peng WS,Qi C,Zhang H,Gao ML,Wang H,Ren F,Li XQ

更新日期：2015-07-01 00:00:00

abstract：:Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) path...

journal_title：Neural regeneration research

authors： Wu CX,Feng YH,Yang L,Zhan ZL,Xu XH,Hu XY,Zhu ZH,Zhou GP

更新日期：2018-09-01 00:00:00

abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...

journal_title：Neural regeneration research

authors： Pan S,Wan J,Liu S,Zhang S,Xiong H,Zhou J,Xiong W,Yu K,Fu Y

更新日期：2013-06-15 00:00:00

abstract：:The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic...

journal_title：Neural regeneration research

authors： Wang W,Townes-Anderson E

更新日期：2016-07-01 00:00:00

abstract：:Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...

journal_title：Neural regeneration research

authors： Morrison BE

更新日期：2016-06-01 00:00:00

abstract：:Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve syst...

journal_title：Neural regeneration research

authors： Wu S,Cao X,He R,Xiong K

更新日期：2012-02-15 00:00:00

abstract：:Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor function. This occurs even when the most meticulous microsurgical techniques or nerve grafts are used. Previous studies had proposed that nerve transfer was more effective than nerve grafting for nerve repair. Our...

journal_title：Neural regeneration research

authors： Wang PJ,Zhang Y,Zhao JJ,Zhou JP,Zuo ZC,Wu BB

更新日期：2017-01-01 00:00:00

abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...

journal_title：Neural regeneration research

authors： Dong S,Tong X,Li J,Huang C,Hu C,Jiao H,Gu Y

更新日期：2013-12-05 00:00:00

abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

journal_title：Neural regeneration research

authors： Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

更新日期：2013-04-15 00:00:00

abstract：:Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear. In this study, we established a model of neurodegenerative disease using PC12 cytotoxic injury induced by glutamate. The cells were treated with 20 mM glutamate in the abs...

journal_title：Neural regeneration research

authors： Liu Y,Liu L,Ying XX,Wei WJ,Han C,Liu Y,Han CH,Leng AJ,Ma JY,Liu J

更新日期：2017-08-01 00:00:00

abstract：Objective:To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury. Data Sources:Key terms were "stroke", "brain diseases", "brain injuries", "brain hemorrhage, traumatic", "acute brain injury", "dizocilpine maleate", "dizocilpine", "MK-801", "MK801", "rat", "ra...

journal_title：Neural regeneration research

authors： Yi NX,Zhou LY,Wang XY,Song YJ,Han HH,Zhang TS,Wang YJ,Shi Q,Xu H,Liang QQ,Zhang T

更新日期：2019-11-01 00:00:00

abstract：:The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeru...

journal_title：Neural regeneration research

authors： Bari BA,Chokshi V,Schmidt K

更新日期：2020-06-01 00:00:00

abstract：:In this study, we hypothesized that an increase in integrin αvβ3 and its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning with bilateral common carotid artery occlusion for 5 minutes in C57BL/6J mice. This was followed by isc...

journal_title：Neural regeneration research

authors： Ma XM,Liu M,Liu YY,Ma LL,Jiang Y,Chen XH

更新日期：2016-05-01 00:00:00

abstract：:Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the ri...

journal_title：Neural regeneration research

authors： Du L,Yang M,Wan L,Wang XH,Li ST

更新日期：2016-10-01 00:00:00