Abstract：
:Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelopathy. Diffusion tensor data were used to predict pathological changes. Results revealed that the fractional anisotropy value gradually decreased at 4, 24, and 72 hours and 1 week after injury in rat spinal cord, showing a time-dependent manner. Average diffusion coefficient increased at 72 hours and 1 week after implantation. Hematoxylin-eosin staining and Luxol-fast-blue staining exhibited that the number of neurons in the anterior horn of the spinal cord gray matter and the nerve fiber density of the white matter gradually reduced with prolonged compression time. Neuronal loss was most significant at 1 week after injury. Results verified that the fractional anisotropy value and average diffusion coefficient reflected the degree of pathological change in the site of compression in rat models at various time points after chronic spinal cord compression injury, which potentially has a reference value in the early diagnosis of chronic cervical spondylotic myelopathy.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Lin E,Long H,Li G,Lei Wdoi
10.3969/j.issn.1673-5374.2013.36.003subject
Has Abstractpub_date
2013-12-25 00:00:00pages
3382-90issue
36eissn
1673-5374issn
1876-7958pii
NRR-8-3382journal_volume
8pub_type
杂志文章abstract：:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...
journal_title：Neural regeneration research
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journal_title：Neural regeneration research
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doi：10.3969/j.issn.1673-5374.2012.21.002
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.155426
更新日期：2015-04-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.18.003
更新日期：2012-06-25 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.17.004
更新日期：2012-06-15 00:00:00
abstract：:Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary vis...
journal_title：Neural regeneration research
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doi：10.4103/1673-5374.167761
更新日期：2015-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.272619
更新日期：2020-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.245467
更新日期：2019-03-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.25.011
更新日期：2012-09-05 00:00:00
abstract：:Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupu...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.193238
更新日期：2016-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.230303
更新日期：2018-04-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.09.007
更新日期：2013-03-25 00:00:00
abstract：:Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before induc...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.135313
更新日期：2014-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.197135
更新日期：2016-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.170313
更新日期：2015-11-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.238715
更新日期：2018-11-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.179032
更新日期：2016-03-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.253508
更新日期：2019-09-01 00:00:00
abstract：:Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positi...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.01.010
更新日期：2012-01-05 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
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更新日期：2014-03-15 00:00:00
abstract：:[This corrects the article on p. 770 in vol. 12, PMID: 28616034.]. ...
journal_title：Neural regeneration research
pub_type： 已发布勘误
doi：10.4103/1673-5374.208598
更新日期：2017-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.211187
更新日期：2017-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.205099
更新日期：2017-04-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.10.009
更新日期：2012-04-05 00:00:00
abstract：:Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.301024
更新日期：2021-07-01 00:00:00
abstract：:After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.133150
更新日期：2014-05-01 00:00:00
abstract：:Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
abstract：:Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of the Alzheimer's drugs targeting amyloid β have been failed in clinical trials...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.274329
更新日期：2020-08-01 00:00:00
abstract：:The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear. In this study, the endovascular puncture method was used to produce a rat model of subarachnoid hemorrhage. Then, 30 minutes later, vascular endothelial growth f...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.257530
更新日期：2019-10-01 00:00:00
