Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury.

abstract：:Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

journal_title：Neural regeneration research

authors： Romeo MA,Faggioni A,Cirone M

更新日期：2019-09-01 00:00:00

abstract：:Three-dimensional (3D) histology utilizes tissue clearing techniques to turn intact tissues transparent, allowing rapid interrogation of tissue architecture in three dimensions. In this article, we summarized the available tissue clearing methods and classified them according to their physicochemical principles of ope...

journal_title：Neural regeneration research

authors： Lai HM,Ng HM,Wu W

更新日期：2017-01-01 00:00:00

abstract：:Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupu...

journal_title：Neural regeneration research

authors： Duan DM,Tu Y,Liu P,Jiao S

更新日期：2016-10-01 00:00:00

abstract：:The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injure...

journal_title：Neural regeneration research

authors： Yin Y,Gu Z,Pan L,Gan L,Qin D,Yang B,Guo J,Hu X,Wang T,Feng Z

更新日期：2013-06-05 00:00:00

abstract：:Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apopto...

journal_title：Neural regeneration research

authors： Wang Z,Xue R,Lei X,Lv J,Wu G,Li W,Xue L,Lei X,Zhao H,Gao H,Wei X

更新日期：2012-10-25 00:00:00

abstract：:Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational...

journal_title：Neural regeneration research

authors： Costa G,De Luca MA,Piras G,Marongiu J,Fattore L,Simola N

更新日期：2020-05-01 00:00:00

abstract：:The present study involved a questionnaire survey of 156 mothers that gave birth to children with neural tube defects or had a history of pregnancy resulting in children with neural tube defects (case group) and 156 control mothers with concurrent healthy children (control group) as well as detection of mitochondrial ...

journal_title：Neural regeneration research

authors： Liu Z,Xie J,Luo T,Zhang T,Zhao X,Zhao H,Li P

更新日期：2012-02-25 00:00:00

abstract：:In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endot...

journal_title：Neural regeneration research

authors： Wang R,Hao D,Shi W,Pu J,Wang Z

更新日期：2012-03-15 00:00:00

abstract：:This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majori...

journal_title：Neural regeneration research

authors： Wu P,Zeng F,Li YX,Yu BL,Qiu LH,Qin W,Li J,Zhou YM,Liang FR

更新日期：2015-05-01 00:00:00

abstract：:One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage a...

journal_title：Neural regeneration research

authors： Lara-Celador I,Goñi-de-Cerio F,Alvarez A,Hilario E

更新日期：2013-03-15 00:00:00

abstract：:In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...

journal_title：Neural regeneration research

authors： Li Q,Zhai Q,Geng J,Zheng H,Chen F,Kong J,Zhang C

更新日期：2012-08-05 00:00:00

abstract：:Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...

journal_title：Neural regeneration research

authors： Ding J,He Z,Ruan J,Liu Y,Gong C,Sun S,Chen H

更新日期：2013-02-05 00:00:00

abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

journal_title：Neural regeneration research

authors： Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

更新日期：2013-04-15 00:00:00

abstract：:The specific and effective α-synuclein RNA interference (RNAi) plasmids, and the α-synuclein-pEGFP recombinant plasmids were co-transfected into human embryonic kidney 293 (HEK293) cells using the lipofectamine method. Using an inverted fluorescence microscope, α-synuclein proteins were observed to aggregate in the cy...

journal_title：Neural regeneration research

authors： Chen T,Liao X,Wen G,Deng Y,Guo M,Long Z,Ouyang F

更新日期：2012-01-15 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：:As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute isch...

journal_title：Neural regeneration research

authors： Huai Y,Dong Y,Xu J,Meng N,Song C,Li W,Lv P

更新日期：2013-07-05 00:00:00

abstract：:Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...

journal_title：Neural regeneration research

authors： Li Y,Cheng JX,Yang HH,Chen LP,Liu FJ,Wu Y,Fan M,Wu HT

更新日期：2021-07-01 00:00:00

abstract：:Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model...

journal_title：Neural regeneration research

authors： Gao BY,Sun CC,Xia GH,Zhou ST,Zhang Y,Mao YR,Liu PL,Zheng Y,Zhao D,Li XT,Xu J,Xu DS,Bai YL

更新日期：2020-11-01 00:00:00

abstract：:Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...

journal_title：Neural regeneration research

authors： Zhao JJ,Liu ZW,Wang B,Huang TQ,Guo D,Zhao YL,Song JN

更新日期：2020-04-01 00:00:00

abstract：:The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil(®) (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressu...

journal_title：Neural regeneration research

authors： Liu H,Ni Z,Chen Y,Wang D,Qi Y,Zhang Q,Wang S

更新日期：2012-04-05 00:00:00

abstract：:A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ische...

journal_title：Neural regeneration research

authors： Xiao F,Xiong L,Wang Q,Zhou L,Zhou Q

更新日期：2012-04-15 00:00:00

abstract：:Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hy...

journal_title：Neural regeneration research

authors： Biazar E,Keshel SH,Pouya M

更新日期：2013-09-25 00:00:00

abstract：:Septic encephalopathy is a frequent complication of sepsis, but there are few studies examining the role of microRNAs (miRs) in its pathogenesis. In this study, a miR-219 mimic was transfected into rat hippocampal neurons to model miR-219 overexpression. A protective effect of miR-219 was observed for glutamate-induce...

journal_title：Neural regeneration research

authors： Wang T,Cai Q,Yang WJ,Fan HH,Yi JF,Xu F

更新日期：2018-07-01 00:00:00

abstract：:Acacetin (5,7-dihydroxy-4'-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an effect on inflammatory corpuscle 3 (NLRP3) after cerebral ischemia-reperfusion injury has not been fully determined. This s...

journal_title：Neural regeneration research

authors： Bu J,Shi S,Wang HQ,Niu XS,Zhao ZF,Wu WD,Zhang XL,Ma Z,Zhang YJ,Zhang H,Zhu Y

更新日期：2019-04-01 00:00:00

abstract：:The three-dimensional (3D) visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there rema...

journal_title：Neural regeneration research

authors： Qi J,Wang WY,Zhong YC,Zhou JM,Luo P,Tang P,He CF,Zhu S,Liu XL,Zhang Y

更新日期：2018-08-01 00:00:00

abstract：:Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear. In this study, we established a model of neurodegenerative disease using PC12 cytotoxic injury induced by glutamate. The cells were treated with 20 mM glutamate in the abs...

journal_title：Neural regeneration research

authors： Liu Y,Liu L,Ying XX,Wei WJ,Han C,Liu Y,Han CH,Leng AJ,Ma JY,Liu J

更新日期：2017-08-01 00:00:00

abstract：:Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve syst...

journal_title：Neural regeneration research

authors： Wu S,Cao X,He R,Xiong K

更新日期：2012-02-15 00:00:00

abstract：:Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse...

journal_title：Neural regeneration research

authors： Mao HF,Xie J,Chen JQ,Tang CF,Chen W,Zhou BC,Chen R,Qu HL,Wu CZ

更新日期：2017-04-01 00:00:00

abstract：:Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...

journal_title：Neural regeneration research

authors： Liu H,Song L,Zhang T

更新日期：2014-08-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...

journal_title：Neural regeneration research

authors： Colpo GD,Stimming EF,Rocha NP,Teixeira AL

更新日期：2017-09-01 00:00:00