Abstract:
:Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction (2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Liu Y,Zhu S,Wang Y,Hu J,Xu L,Ding L,Liu Gdoi
10.4103/1673-5374.135313subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1117-21issue
11eissn
1673-5374issn
1876-7958pii
NRR-9-1117journal_volume
9pub_type
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