Abstract:
:Injuries to the central or peripheral nervous system frequently cause long-term disabilities because damaged neurons are unable to efficiently self-repair. This inherent deficiency necessitates the need for new treatment options aimed at restoring lost function to patients. Compared to humans, a number of species possess far greater regenerative capabilities, and can therefore provide important insights into how our own nervous systems can be repaired. In particular, several invertebrate species have been shown to rapidly initiate regeneration post-injury, allowing separated axon segments to re-join. This process, known as axonal fusion, represents a highly efficient repair mechanism as a regrowing axon needs to only bridge the site of damage and fuse with its separated counterpart in order to re-establish its original structure. Our recent findings in the nematode Caenorhabditis elegans have expanded the promise of axonal fusion by demonstrating that it can restore complete function to damaged neurons. Moreover, we revealed the importance of injury-induced changes in the composition of the axonal membrane for mediating axonal fusion, and discovered that the level of axonal fusion can be enhanced by promoting a neuron's intrinsic growth potential. A complete understanding of the molecular mechanisms controlling axonal fusion may permit similar approaches to be applied in a clinical setting.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Teoh JS,Wong MY,Vijayaraghavan T,Neumann Bdoi
10.4103/1673-5374.230271subject
Has Abstractpub_date
2018-04-01 00:00:00pages
591-594issue
4eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2018_13_4_591_230271journal_volume
13pub_type
杂志文章,评审abstract::Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion inj...
journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.09.007
更新日期:2013-03-25 00:00:00
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doi:10.3969/j.issn.1673-5374.2013.12.001
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