Abstract:
:Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were treated with 2.4% sevoflurane for 30 minutes after hypoxic-ischemic injury. Our results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats, decreased astrogliosis and glial scar formation, increased numbers of dendritic spines, and protected the histomorphology of the hippocampus. Mechanistically, sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of DJ-1. Injection of 1.52 μg of the hypoxia-inducible factor-1α inhibitor YC-1 (Lificiguat) into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by sevoflurane. This finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic injury. The underlying mechanism may be related to upregulated DJ-1 expression, reduced ubiquitination of hypoxia-inducible factor-1α, and stabilized hypoxia-inducible factor-1α expression. This study was approved by the Laboratory Animal Care Committee of China Medical University, China (approval No. 2016PS337K) on November 9, 2016.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Gao QS,Zhang YH,Xue H,Wu ZY,Li C,Zhao Pdoi
10.4103/1673-5374.300456subject
Has Abstractpub_date
2021-06-01 00:00:00pages
1052-1061issue
6eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_6_1052_300456journal_volume
16pub_type
杂志文章abstract::New Zealand rabbits were randomly divided into an ischemia group (occlusion of the abdominal aorta for 60 minutes), an ischemia-reperfusion group (occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group. Two-dimensional gel electrophoresis detected 49 differentiall...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.20.002
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abstract::Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of...
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2012.23.002
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2012.31.001
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.22.001
更新日期:2013-08-05 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.211197
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.306061
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.162686
更新日期:2015-08-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.170313
更新日期:2015-11-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.247422
更新日期:2019-04-01 00:00:00
abstract::The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.182712
更新日期:2016-05-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.169638
更新日期:2016-02-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.198964
更新日期:2017-01-01 00:00:00
abstract::Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brai...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.130060
更新日期:2014-03-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.295312
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pub_type: 杂志文章,评审
doi:10.4103/1673-5374.268895
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
abstract::Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.139479
更新日期:2014-08-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.253527
更新日期:2019-08-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.265562
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journal_title:Neural regeneration research
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更新日期:2020-01-01 00:00:00
abstract::In this study, primary cultured cerebral cortical neurons of Sprague-Dawley neonatal rats were treated with 0.25, 0.5, and 1.0 μM calmodulin-dependent protein kinase II inhibitor KN-93 after 50 μM N-methyl-D-aspartic acid-induced injury. Results showed that, compared with N-methyl-Daspartic acid-induced injury neurons...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.02.002
更新日期:2013-01-15 00:00:00
abstract::A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeos...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00