Abstract：
:Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare systems as AD patients' relatives and healthcare workers are forced to cope with rising numbers of affected people. Despite recent advances, AD pathological mechanisms are not fully understood. Nevertheless, it is clear that the amyloid beta (Aβ) peptide, which forms amyloid plaques in AD patients' brains, plays a key role. Type 2 diabetes, the most common form of diabetes, affects hundreds of million people globally. Islet amyloid polypeptide (IAPP) is a hormone co-produced and secreted with insulin in pancreatic β-cells, with a key role in diabetes, as it helps regulate glucose levels and control adiposity and satiation. Similarly to Aβ, IAPP is very amyloidogenic, generating intracellular amyloid deposits that cause β-cell dysfunction and death. It is now clear that IAPP can also have a pathological role in AD, decreasing cognitive function. IAPP harms the blood-brain barrier, directly interacts and co-deposits with Aβ, promoting diabetes-associated dementia. IAPP can cause a metabolic dysfunction in the brain, leading to other diabetes-related forms of AD. Thus, here we discuss IAPP association with diabetes, Aβ and dementia, in the context of what we designate a "diabetes brain phenotype" AD hypothesis. Such approach helps to set a conceptual framework for future IAPP-based drugs against AD.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Ferreira S,Raimundo AF,Menezes R,Martins ICdoi
10.4103/1673-5374.300323subject
Has Abstractpub_date
2021-06-01 00:00:00pages
1127-1130issue
6eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_6_1127_300323journal_volume
16pub_type
杂志文章,评审abstract：:Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Neural regeneration research
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doi：10.4103/1673-5374.137575
更新日期：2014-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.29.001
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abstract：:Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone f...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.295312
更新日期：2021-04-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.01.005
更新日期：2013-01-05 00:00:00
abstract：:Three male patients were diagnosed with new cortical infarctions of the right parietal lobe on the basis of head magnetic resonance imaging; high-intensity signals indicating lesions in the right parietal lobe were noted on diffusion-weighted images at admission. Two of them presented with left hand weakness, and one ...
journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2012.12.011
更新日期：2012-04-25 00:00:00
abstract：:Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to gene...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.23.001
更新日期：2013-08-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.150706
更新日期：2015-01-01 00:00:00
abstract：:Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was establi...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.294565
更新日期：2021-08-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.265557
更新日期：2020-02-01 00:00:00
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journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2013.05.012
更新日期：2013-02-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.125326
更新日期：2014-01-01 00:00:00
abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.155433
更新日期：2015-04-01 00:00:00
abstract：:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the t...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.162765
更新日期：2015-08-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.284980
更新日期：2020-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.233446
更新日期：2018-06-01 00:00:00
abstract：:The relative frequencies of different subtypes of limb-girdle muscular dystrophies vary widely among different populations. We estimated the percentage of limb-girdle muscular dystrophy subtypes in Chinese people based on 68 patients with limb-girdle muscular dystrophy from the Myology Clinic, Neurology Department, Fi...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.20.010
更新日期：2013-07-15 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.206653
更新日期：2017-05-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.202931
更新日期：2017-03-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.04.008
更新日期：2012-02-05 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.04.002
更新日期：2013-02-05 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.221168
更新日期：2017-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.187055
更新日期：2016-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.270297
更新日期：2020-06-01 00:00:00
abstract：:A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.286972
更新日期：2021-02-01 00:00:00
abstract：Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.266064
更新日期：2020-03-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.19.003
更新日期：2012-07-05 00:00:00
abstract：:Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of the Alzheimer's drugs targeting amyloid β have been failed in clinical trials...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.274329
更新日期：2020-08-01 00:00:00
abstract：:Proanthocyanidins have been shown to effectively protect ischemic neurons, but its mechanism remains poorly understood. Ginkgo proanthocyanidins (20, 40, 80 mg/kg) were intraperitoneally administered 1, 24, 48 and 72 hours before reperfusion. Results showed that ginkgo proanthocyanidins could effectively mitigate neur...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.194722
更新日期：2016-11-01 00:00:00
