Propofol promotes spinal cord injury repair by bone marrow mesenchymal stem cell transplantation.

Abstract:

:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the tail vein. Rat spinal cord injury was clearly alleviated; a large number of newborn non-myelinated and myelinated nerve fibers appeared in the spinal cord, the numbers of CM-Dil-labeled bone marrow mesenchymal stem cells and fluorogold-labeled nerve fibers were increased and hindlimb motor function of spinal cord-injured rats was markedly improved. These improvements were more prominent in rats subjected to bone marrow mesenchymal cell transplantation combined with propofol administration than in rats receiving monotherapy. These results indicate that propofol can enhance the therapeutic effects of bone marrow mesenchymal stem cell transplantation on spinal cord injury in rats.

journal_name

Neural Regen Res

authors

Zhou YJ,Liu JM,Wei SM,Zhang YH,Qu ZH,Chen SB

doi

10.4103/1673-5374.162765

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1305-11

issue

8

eissn

1673-5374

issn

1876-7958

pii

NRR-10-1305

journal_volume

10

pub_type

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