Abstract:
:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the tail vein. Rat spinal cord injury was clearly alleviated; a large number of newborn non-myelinated and myelinated nerve fibers appeared in the spinal cord, the numbers of CM-Dil-labeled bone marrow mesenchymal stem cells and fluorogold-labeled nerve fibers were increased and hindlimb motor function of spinal cord-injured rats was markedly improved. These improvements were more prominent in rats subjected to bone marrow mesenchymal cell transplantation combined with propofol administration than in rats receiving monotherapy. These results indicate that propofol can enhance the therapeutic effects of bone marrow mesenchymal stem cell transplantation on spinal cord injury in rats.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhou YJ,Liu JM,Wei SM,Zhang YH,Qu ZH,Chen SBdoi
10.4103/1673-5374.162765subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1305-11issue
8eissn
1673-5374issn
1876-7958pii
NRR-10-1305journal_volume
10pub_type
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pub_type: 杂志文章,评审
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pub_type: 已发布勘误
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