当前位置： SCI文献检索 > Neural Regeneration Research期刊下所有文献 > Mash1 efficiently reprograms rat astrocytes into neurons.

Mash1 efficiently reprograms rat astrocytes into neurons.

Abstract：

:To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mash1 was not detectable. Thus, we hypothesized that Mash1 alone could be used to reprogram astrocytes into neurons. We transfected a recombinant MSCV-MASH1 plasmid into astrocytes for 72 hours, and saw that all cells expressed Mash1. One week later, we observed the changes in morphology of astrocytes, which showed typical neuronal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mash1 than in control cells. These results indicate that Mash1 alone can reprogram astrocytes into neurons.

journal_name

Neural Regen Res

journal_title

Neural regeneration research

authors

Ding D,Xu L,Xu H,Li X,Liang Q,Zhao Y,Wang Y

doi

10.4103/1673-5374.125326

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

25-32

issue

1

eissn

1673-5374

issn

1876-7958

pii

NRR-9-25

journal_volume

9

pub_type

杂志文章

相关文献

Neural Regeneration Research文献大全
  • Total flavonoid of Litsea coreana leve exerts anti-oxidative effects and alleviates focal cerebral ischemia/reperfusion injury.

    abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.34.003

    authors： Dong S,Tong X,Li J,Huang C,Hu C,Jiao H,Gu Y

    更新日期：2013-12-05 00:00:00

  • Microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in dorsal root ganglia and neuropathic pain.

    abstract：:Schwann cell transplantation is a promising method to promote neural repair, and can be used for peripheral nerve protection and myelination. Microcapsule technology largely mitigates immune rejection of transplanted cells. We previously showed that microencapsulated olfactory ensheathing cells can reduce neuropathic ...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.238715

    authors： Zhang YL,Chen DJ,Yang BL,Liu TT,Li JJ,Wang XQ,Xue GY,Liu ZX

    更新日期：2018-11-01 00:00:00

  • Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy.

    abstract：:One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroenceph...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.03.002

    authors： Wang W,Fan Z,Zhang Y,Yang Y,Liu Y,Dang X,Song W,Wu Y,Ye J

    更新日期：2013-01-25 00:00:00

  • Recanalization of extracranial internal carotid artery occlusion: A 12-year retrospective study.

    abstract：:This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extracranial internal carotid artery occlusion. The study included 65 patients with extracranial internal carotid artery occlusion who u...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.23.011

    authors： Jiao L,Song G,Hua Y,Ma Y,Chen Y,Wang Y,Ling F

    更新日期：2013-08-15 00:00:00

  • Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study.

    abstract：:Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.139465

    authors： Liu H,Song L,Zhang T

    更新日期：2014-08-01 00:00:00

  • High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis.

    abstract：:Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among ankylosing spondylitis patients for 1 year aft...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.156988

    authors： Xue HX,Fu WY,Cui HD,Yang LL,Zhang N,Zhao LJ

    更新日期：2015-05-01 00:00:00

  • Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries.

    abstract：OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.130094

    authors： He B,Zhu Z,Zhu Q,Zhou X,Zheng C,Li P,Zhu S,Liu X,Zhu J

    更新日期：2014-03-15 00:00:00

  • Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice: the underlying mechanism.

    abstract：:Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) path...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.235294

    authors： Wu CX,Feng YH,Yang L,Zhan ZL,Xu XH,Hu XY,Zhu ZH,Zhou GP

    更新日期：2018-09-01 00:00:00

  • Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence- accelerated mouse.

    abstract：:At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cycl...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.12.001

    authors： Zhang Z,Zhang T,Dong K

    更新日期：2012-04-25 00:00:00

  • Human umbilical cord blood-derived stem cells and brain-derived neurotrophic factor protect injured optic nerve: viscoelasticity characterization.

    abstract：:The optic nerve is a viscoelastic solid-like biomaterial. Its normal stress relaxation and creep properties enable the nerve to resist constant strain and protect it from injury. We hypothesized that stress relaxation and creep properties of the optic nerve change after injury. More-over, human brain-derived neurotrop...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.180753

    authors： Lv XM,Liu Y,Wu F,Yuan Y,Luo M

    更新日期：2016-04-01 00:00:00

  • Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice.

    abstract：:Mecobalamin, a form of vitamin B12 containing a central metal element (cobalt), is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve c...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.145379

    authors： Gan L,Qian M,Shi K,Chen G,Gu Y,Du W,Zhu G

    更新日期：2014-11-15 00:00:00

  • A self-made, low-cost infrared system for evaluating the sciatic functional index in mice.

    abstract：:The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.182712

    authors： Fricker L,Penna V,Lampert F,Stark GB,Witzel C,Koulaxouzidis G

    更新日期：2016-05-01 00:00:00

  • Sensory reinnervation of free flaps in reconstruction of the breast and the upper and lower extremities.

    abstract：:There is long-standing debate about sensate versus non-sensate free microvascular flaps among microsurgeons. The principle of connecting not only the vascular supply, but also sensitive nerves, in free tissue transfer is attractive. However, increased operating time and partial spontaneous innervation led to the commo...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.29.006

    authors： Sinis N,Lamia A,Gudrun H,Schoeller T,Werdin F

    更新日期：2012-10-15 00:00:00

  • Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats.

    abstract：:Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesiz...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.27.001

    authors： Vafaee F,Zangiabadi N,Pour FM,Dehghanian F,Asadi-Shekaari M,Afshar HK

    更新日期：2012-09-25 00:00:00

  • Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats.

    abstract：:Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Daw...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.217345

    authors： Lai SM,Gu ZT,Zhao MM,Li XX,Ma YX,Luo L,Liu J

    更新日期：2017-10-01 00:00:00

  • The role of autophagic and lysosomal pathways in ischemic brain injury.

    abstract：:Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to gene...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.23.001

    authors： Gu Z,Sun Y,Liu K,Wang F,Zhang T,Li Q,Shen L,Zhou L,Dong L,Shi N,Zhang Q,Zhang W,Zhao M,Sun X

    更新日期：2013-08-15 00:00:00

  • Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.

    abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.253535

    authors： Tanokashira D,Fukuokaya W,Taguchi A

    更新日期：2019-08-01 00:00:00

  • Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion.

    abstract：:Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expre...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.31.001

    authors： Xin H,Liang W,Mang J,Lin L,Guo N,Zhang F,Xu Z

    更新日期：2012-11-05 00:00:00

  • Connexin: a potential novel target for protecting the central nervous system?

    abstract：:Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings regarding the role of connexins/hemichannels...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.155444

    authors： Xie HY,Cui Y,Deng F,Feng JC

    更新日期：2015-04-01 00:00:00

  • Progesterone promotes neuronal differentiation of human umbilical cord mesenchymal stem cells in culture conditions that mimic the brain microenvironment.

    abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.25.001

    authors： Wang X,Wu H,Xue G,Hou Y

    更新日期：2012-09-05 00:00:00

  • Tissue-type plasminogen activator is a homeostatic regulator of synaptic function in the central nervous system.

    abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.202924

    authors： Jeanneret V,Yepes M

    更新日期：2017-03-01 00:00:00

  • Transplantation of vascular endothelial growth factor-modified neural stem/progenitor cells promotes the recovery of neurological function following hypoxic-ischemic brain damage.

    abstract：:Neural stem/progenitor cell (NSC) transplantation has been shown to effectively improve neurological function in rats with hypoxic-ischemic brain damage. Vascular endothelial growth factor (VEGF) is a signaling protein that stimulates angiogenesis and improves neural regeneration. We hypothesized that transplantation ...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.191220

    authors： Yao Y,Zheng XR,Zhang SS,Wang X,Yu XH,Tan JL,Yang YJ

    更新日期：2016-09-01 00:00:00

  • Saccharomyces cerevisiae in neuroscience: how unicellular organism helps to better understand prion protein?

    abstract：:The baker's yeast Saccharomyces (S.) cerevisiae is a single-celled eukaryotic model organism widely used in research on life sciences. Being a unicellular organism, S. cerevisiae has some evident limitations in application to neuroscience. However, yeast prions are extensively studied and they are known to share some ...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.293137

    authors： Ishikawa T

    更新日期：2021-03-01 00:00:00

  • Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding.

    abstract：:Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding; however, the interplay between these two factors is less studied. While previous work has shown that the biochemical identity of the matrix can alter the outgrowth of neurites in response to neurotrophins, the im...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.155426

    authors： Madl CM,Heilshorn SC

    更新日期：2015-04-01 00:00:00

  • Curcumin pretreatment and post-treatment both improve the antioxidative ability of neurons with oxygen-glucose deprivation.

    abstract：:Recent studies have shown that induced expression of endogenous antioxidative enzymes thr-ough activation of the antioxidant response element/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway may be a neuroprotective strategy. In this study, rat cerebral cortical neurons cultured in vitro were pretreated with...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.153700

    authors： Wu JX,Zhang LY,Chen YL,Yu SS,Zhao Y,Zhao J

    更新日期：2015-03-01 00:00:00

  • Olfactory route for cerebrospinal fluid drainage into the cervical lymphatic system in a rabbit experimental model.

    abstract：:The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil(®) (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressu...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.10.009

    authors： Liu H,Ni Z,Chen Y,Wang D,Qi Y,Zhang Q,Wang S

    更新日期：2012-04-05 00:00:00

  • Optical control after transfection of channelrhodopsin-2 recombinant adenovirus in visual cortical cells.

    abstract：:Channelrhodopsin-2 ectopically expressed in the retina can recover the response to blue light in genetically blind mice and rats, but is unable to restore visual function due to optic nerve or optic tract lesions. Long Evans rats at postnatal day 1 were used for primary culture of visual cortical cells, and 24 hours l...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.16.004

    authors： Yao J,Hou W,Wang H,Liu H,Weng C,Yin Z

    更新日期：2012-06-05 00:00:00

  • Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration.

    abstract：:Neurotoxicity induced by stress, radiation, chemicals, or metabolic diseases, is commonly associated with excitotoxicity, oxidative stress, and neuroinflammation. The pathological process of neurotoxicity induces neuronal death, interrupts synaptic plasticity in the brain, and is similar to that of diverse neurodegene...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.217353

    authors： Kim J,Lee S,Kang S,Kim SH,Kim JC,Yang M,Moon C

    更新日期：2017-10-01 00:00:00

  • Locus coeruleus-norepinephrine: basic functions and insights into Parkinson's disease.

    abstract：:The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeru...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.270297

    authors： Bari BA,Chokshi V,Schmidt K

    更新日期：2020-06-01 00:00:00

  • Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.

    abstract：:A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibi...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.13.008

    authors： Xie Y,Liu Y,Shen W,Zhang B,Liu Q

    更新日期：2012-05-05 00:00:00