Abstract:
:Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against ischemic cerebral injury. To validate this hypothesis, rats were intraperitoneally administered with 0.66 mL/kg Setarud for 30 minutes after middle cerebral artery occlusion. Triphenyltetrazolium chloride staining showed that Setarud could reduce cerebral infarct volume of rats subjected to cerebral ischemia. Transmission electron microscopy and hematoxylin-eosin staining results showed that Setarud could alleviate the degenerative changes in cortical neurons of rats with cerebral ischemia. The inclined plate test and prehensile test showed that Setarud could significantly improve the motor function of rats with cerebral ischemia. These findings suggest that Setarud shows neuroprotective effects against ischemic brain injury.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Vafaee F,Zangiabadi N,Pour FM,Dehghanian F,Asadi-Shekaari M,Afshar HKdoi
10.3969/j.issn.1673-5374.2012.27.001subject
Has Abstractpub_date
2012-09-25 00:00:00pages
2085-91issue
27eissn
1673-5374issn
1876-7958pii
NRR-7-2085journal_volume
7pub_type
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