Abstract：
:There is long-standing debate about sensate versus non-sensate free microvascular flaps among microsurgeons. The principle of connecting not only the vascular supply, but also sensitive nerves, in free tissue transfer is attractive. However, increased operating time and partial spontaneous innervation led to the common decision to restrict microsurgical tissue transfer to the vascular anastomosis and to leave the nerves "untreated". Nevertheless, in special cases such as breast reconstruction or extremity reconstruction, the question about sensory nerve coaptation of the flaps remains open. We present our experience with free microvascular tissue transfer for breast and extremity reconstruction and compare the data with previous literature and conclude that most free flap surgeries do not benefit from nerve coaptation.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Sinis N,Lamia A,Gudrun H,Schoeller T,Werdin Fdoi
10.3969/j.issn.1673-5374.2012.29.006subject
Has Abstractpub_date
2012-10-15 00:00:00pages
2279-85issue
29eissn
1673-5374issn
1876-7958pii
NRR-7-2279journal_volume
7pub_type
杂志文章abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.247422
更新日期：2019-04-01 00:00:00
abstract：:Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.219055
更新日期：2017-11-01 00:00:00
abstract：:Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.150706
更新日期：2015-01-01 00:00:00
abstract：:Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.276323
更新日期：2020-09-01 00:00:00
abstract：:Three male patients were diagnosed with new cortical infarctions of the right parietal lobe on the basis of head magnetic resonance imaging; high-intensity signals indicating lesions in the right parietal lobe were noted on diffusion-weighted images at admission. Two of them presented with left hand weakness, and one ...
journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2012.12.011
更新日期：2012-04-25 00:00:00
abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.18.003
更新日期：2012-06-25 00:00:00
abstract：:Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.228758
更新日期：2018-03-01 00:00:00
abstract：:Indirubin-3'-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. Here, we found that indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), an...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.184500
更新日期：2016-06-01 00:00:00
abstract：:Insulin-like growth factor 1 (IGF-1) is a potential nutrient for nerve repair. However, it is impractical as a therapy because of its limited half-life, rapid clearance, and limited target specificity. To achieve targeted and long-lasting treatment, we investigated the addition of a binding structure by fusing a colla...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.226400
更新日期：2018-02-01 00:00:00
abstract：:This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.175057
更新日期：2016-01-01 00:00:00
abstract：:At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cycl...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.12.001
更新日期：2012-04-25 00:00:00
abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.245472
更新日期：2019-03-01 00:00:00
abstract：:Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.266914
更新日期：2020-04-01 00:00:00
abstract：:The optic nerve is a viscoelastic solid-like biomaterial. Its normal stress relaxation and creep properties enable the nerve to resist constant strain and protect it from injury. We hypothesized that stress relaxation and creep properties of the optic nerve change after injury. More-over, human brain-derived neurotrop...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.180753
更新日期：2016-04-01 00:00:00
abstract：:Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.257536
更新日期：2019-10-01 00:00:00
abstract：:[This corrects the article on p. 770 in vol. 12, PMID: 28616034.]. ...
journal_title：Neural regeneration research
pub_type： 已发布勘误
doi：10.4103/1673-5374.208598
更新日期：2017-06-01 00:00:00
abstract：:Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding; however, the interplay between these two factors is less studied. While previous work has shown that the biochemical identity of the matrix can alter the outgrowth of neurites in response to neurotrophins, the im...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.155426
更新日期：2015-04-01 00:00:00
abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.221158
更新日期：2017-12-01 00:00:00
abstract：:In this study, primary cultured cerebral cortical neurons of Sprague-Dawley neonatal rats were treated with 0.25, 0.5, and 1.0 μM calmodulin-dependent protein kinase II inhibitor KN-93 after 50 μM N-methyl-D-aspartic acid-induced injury. Results showed that, compared with N-methyl-Daspartic acid-induced injury neurons...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.02.002
更新日期：2013-01-15 00:00:00
abstract：:Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.139479
更新日期：2014-08-15 00:00:00
abstract：:The present study involved a questionnaire survey of 156 mothers that gave birth to children with neural tube defects or had a history of pregnancy resulting in children with neural tube defects (case group) and 156 control mothers with concurrent healthy children (control group) as well as detection of mitochondrial ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2011.06.010
更新日期：2012-02-25 00:00:00
abstract：:[This corrects the article DOI: 10.4103/1673-5374.245480]. ...
journal_title：Neural regeneration research
pub_type： 杂志文章,已发布勘误
doi：10.4103/1673-5374.250633
更新日期：2019-06-01 00:00:00
abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.17.002
更新日期：2013-06-15 00:00:00
abstract：:The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear. In this study, the endovascular puncture method was used to produce a rat model of subarachnoid hemorrhage. Then, 30 minutes later, vascular endothelial growth f...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.257530
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.206653
更新日期：2017-05-01 00:00:00
abstract：:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the t...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.162765
更新日期：2015-08-01 00:00:00
abstract：:Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on s...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.172328
更新日期：2015-12-01 00:00:00
abstract：:Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.221168
更新日期：2017-12-01 00:00:00
abstract：:A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarin...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.09.004
更新日期：2012-03-25 00:00:00
abstract：:Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.205099
更新日期：2017-04-01 00:00:00
