Abstract：
:Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days after the trauma, and provide valuable therapeutic targets to prevent further neuronal degeneration. At the present time, there is no effective treatment for TBI due, in part, to the widespread impact of numerous complex secondary biochemical and pathophysiological events occurring at different time points following the initial injury. MicroRNAs control a range of physiological and pathological functions such as development, differentiation, apoptosis and metabolism, and may serve as potential targets for progress assessment and intervention against TBI to mitigate secondary damage to the brain. This has implications regarding improving the diagnostic accuracy of brain impairment and long-term outcomes as well as potential novel treatments. Recent human studies have identified specific microRNAs in serum/plasma (miR-425-p, -21, -93, -191 and -499) and cerebro-spinal fluid (CSF) (miR-328, -362-3p, -451, -486a) as possible indicators of the diagnosis, severity, and prognosis of TBI. Experimental animal studies have examined specific microRNAs as biomarkers and therapeutic targets for moderate and mild TBI (e.g., miR-21, miR-23b). MicroRNA profiling was altered by voluntary exercise. Differences in basal microRNA expression in the brain of adult and aged animals and alterations in response to TBI (e.g., miR-21) have also been reported. Further large-scale studies with TBI patients are needed to provide more information on the changes in microRNA profiles in different age groups (children, adults, and elderly).
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Martinez B,Peplow PVdoi
10.4103/1673-5374.219025subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1749-1761issue
11eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2017_12_11_1749_219025journal_volume
12pub_type
杂志文章,评审abstract：:The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepez...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.194708
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abstract：:Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and J...
journal_title：Neural regeneration research
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doi：10.4103/1673-5374.150716
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.131591
更新日期：2014-04-15 00:00:00
abstract：:Single-chain variable domain fragment (scFv) 637 is an antigen-specific scFv of myasthenia gravis. In this study, scFv and human serum albumin genes were conjugated and the fusion protein was expressed in Pichia pastoris. The affinity of scFv-human serum albumin fusion protein to bind to acetylcholine receptor at the ...
journal_title：Neural regeneration research
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doi：10.4103/1673-5374.131611
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abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.135313
更新日期：2014-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.238715
更新日期：2018-11-01 00:00:00
abstract：:Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to di...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.179032
更新日期：2016-03-01 00:00:00
abstract：:The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that el...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.213534
更新日期：2017-08-01 00:00:00
abstract：:Human umbilical mesenchymal stem cells from Wharton's jelly of the umbilical cord were induced to differentiate into oligodendrocyte precursor-like cells in vitro. Oligodendrocyte precursor cells were transplanted into contused rat spinal cords. Immunofluorescence double staining indicated that transplanted cells surv...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.10.003
更新日期：2013-04-05 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.131577
更新日期：2014-04-01 00:00:00
abstract：:Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.257536
更新日期：2019-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.26.001
更新日期：2013-09-15 00:00:00
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journal_title：Neural regeneration research
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doi：10.4103/1673-5374.230294
更新日期：2018-04-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.262596
更新日期：2019-12-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.259624
更新日期：2019-11-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.08.006
更新日期：2012-03-15 00:00:00
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更新日期：2020-10-01 00:00:00
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journal_title：Neural regeneration research
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更新日期：2015-04-01 00:00:00
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journal_title：Neural regeneration research
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更新日期：2013-08-15 00:00:00
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更新日期：2015-06-01 00:00:00
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更新日期：2013-04-15 00:00:00
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