Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease.

Abstract:

:This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β. Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyperlipidemia. For prevention and treatment of Alzheimer's disease, curcumin has been shown to effectively maintain the normal structure and function of cerebral vessels, mitochondria, and synapses, reduce risk factors for a variety of chronic diseases, and decrease the risk of Alzheimer's disease. The effect of curcumin on Alzheimer's disease involves multiple signaling pathways: anti-amyloid and metal iron chelating properties, antioxidation and anti-inflammatory activities. Indeed, there is a scientific basis for the rational application of curcumin in prevention and treatment of Alzheimer's disease.

journal_name

Neural Regen Res

authors

Chen M,Du ZY,Zheng X,Li DL,Zhou RP,Zhang K

doi

10.4103/1673-5374.230303

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

742-752

issue

4

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2018_13_4_742_230303

journal_volume

13

pub_type

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