The role of autophagic and lysosomal pathways in ischemic brain injury.

abstract：:Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hy...

journal_title：Neural regeneration research

authors： Biazar E,Keshel SH,Pouya M

更新日期：2013-09-25 00:00:00

abstract：:Neuropathic pain after spinal cord injury (SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy; nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the a...

journal_title：Neural regeneration research

authors： Batista CM,Mariano ED,Dale CS,Cristante AF,Britto LR,Otoch JP,Teixeira MJ,Morgalla M,Lepski G

更新日期：2019-11-01 00:00:00

abstract：:Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or ...

journal_title：Neural regeneration research

authors： Xia P,Pan S,Cheng J,Yang M,Qi Z,Hou T,Yang X

更新日期：2014-09-15 00:00:00

abstract：:The present study involved a questionnaire survey of 156 mothers that gave birth to children with neural tube defects or had a history of pregnancy resulting in children with neural tube defects (case group) and 156 control mothers with concurrent healthy children (control group) as well as detection of mitochondrial ...

journal_title：Neural regeneration research

authors： Liu Z,Xie J,Luo T,Zhang T,Zhao X,Zhao H,Li P

更新日期：2012-02-25 00:00:00

abstract：:Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...

journal_title：Neural regeneration research

authors： Zheng G,Chen X,Xu B,Zhang J,Lv X,Li J,Li F,Hu S,Zhang T,Li Y

更新日期：2013-03-05 00:00:00

abstract：:Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupu...

journal_title：Neural regeneration research

authors： Duan DM,Tu Y,Liu P,Jiao S

更新日期：2016-10-01 00:00:00

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion inj...

journal_title：Neural regeneration research

authors： Zhang L,Gan W,An G

更新日期：2012-12-25 00:00:00

abstract：:A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarin...

journal_title：Neural regeneration research

authors： Chen M,Wang J,Ming C

更新日期：2012-03-25 00:00:00

abstract：:Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

journal_title：Neural regeneration research

authors： Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

更新日期：2016-12-01 00:00:00

abstract：:Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...

journal_title：Neural regeneration research

authors： Chen G,Hu T,Li Q,Li J,Jia Y,Wang Z

更新日期：2013-10-15 00:00:00

abstract：:Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) path...

journal_title：Neural regeneration research

authors： Wu CX,Feng YH,Yang L,Zhan ZL,Xu XH,Hu XY,Zhu ZH,Zhou GP

更新日期：2018-09-01 00:00:00

abstract：:Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesiz...

journal_title：Neural regeneration research

authors： Vafaee F,Zangiabadi N,Pour FM,Dehghanian F,Asadi-Shekaari M,Afshar HK

更新日期：2012-09-25 00:00:00

abstract：:End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps, compared to repairs with a graft. However, grafts are typically used to enable a tension-free repair for moderate to large gaps, as excessive tension can cause repairs to fail and catastrophically impede recover...

journal_title：Neural regeneration research

authors： Howarth HM,Alaziz T,Nicolds B,O'Connor S,Shah SB

更新日期：2019-07-01 00:00:00

abstract：:Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substan...

journal_title：Neural regeneration research

authors： Shaimardanova AA,Solovyeva VV,Chulpanova DS,James V,Kitaeva KV,Rizvanov AA

更新日期：2020-04-01 00:00:00

abstract：:Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic...

journal_title：Neural regeneration research

authors： Nociti V,Santoro M

更新日期：2021-09-01 00:00:00

abstract：:Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infar...

journal_title：Neural regeneration research

authors： He ZP,Lu H

更新日期：2015-07-01 00:00:00

abstract：:To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case o...

journal_title：Neural regeneration research

authors： Seo Y,Shin MH,Kim SG,Kim JH

更新日期：2013-01-15 00:00:00

abstract：:The study aims to confirm the neuroregenerative effects of bacterial melanin (BM) on central nervous system injury using a special staining method based on the detection of Ca(2+)-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor corte...

journal_title：Neural regeneration research

authors： Petrosyan TR,Ter-Markosyan AS,Hovsepyan AS

更新日期：2016-07-01 00:00:00

abstract：:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the t...

journal_title：Neural regeneration research

authors： Zhou YJ,Liu JM,Wei SM,Zhang YH,Qu ZH,Chen SB

更新日期：2015-08-01 00:00:00

abstract：:A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibi...

journal_title：Neural regeneration research

authors： Xie Y,Liu Y,Shen W,Zhang B,Liu Q

更新日期：2012-05-05 00:00:00

abstract：:Endothelial progenitor cells secrete a variety of growth factors that inhibit inflammation, promote angiogenesis and exert neuroprotective effects. Therefore, in this study, we investigated whether endothelial progenitor cell-conditioned medium might have therapeutic effectiveness for the treatment of spinal cord inju...

journal_title：Neural regeneration research

authors： Wang T,Fang X,Yin ZS

更新日期：2018-05-01 00:00:00

abstract：:This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...

journal_title：Neural regeneration research

authors： Kwon YH,Kang KW,Lee NK,Son SM

更新日期：2016-01-01 00:00:00

abstract：:TMP269 is a selective class IIA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. ...

journal_title：Neural regeneration research

authors： Su L,Liang D,Kuang SY,Dong Q,Han X,Wang Z

更新日期：2020-02-01 00:00:00

abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...

journal_title：Neural regeneration research

authors： Kim J,Im HI,Moon C

更新日期：2018-01-01 00:00:00

abstract：:This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based m...

journal_title：Neural regeneration research

authors： Tan L,Zhang L,Qi R,Lu G,Li L,Liu J,Li W

更新日期：2013-09-15 00:00:00

abstract：:Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...

journal_title：Neural regeneration research

authors： Cao X,Fang L,Cui CY,Gao S,Wang TW

更新日期：2018-03-01 00:00:00

abstract：:As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in th...

journal_title：Neural regeneration research

authors： Agatonovic-Kustrin S,Kustrin E,Morton DW

更新日期：2019-03-01 00:00:00

abstract：:Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before induc...

journal_title：Neural regeneration research

authors： Liu Y,Zhu S,Wang Y,Hu J,Xu L,Ding L,Liu G

更新日期：2014-06-01 00:00:00