Abstract:
:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into neuron-like cells. To evaluate the effects of progesterone as a neurosteroid on the neuronal differentiation of human umbilical cord mesenchymal stem cells, we cultured the cells in medium containing progesterone (0.1, 1, 10 μM) in addition to brain tissue extracts. Reverse transcription-PCR and flow cytometric analysis of neuron specific enolase-positive cells revealed that the percentages of these cells increased significantly following progesterone treatment, with the optimal progesterone concentration for neuron-like differentiation being 1 μM. These results suggest that progesterone can enhance the neuronal differentiation of human umbilical cord mesenchymal stem cells in culture medium containing brain tissue extracts to mimic the brain microenvironment.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Wang X,Wu H,Xue G,Hou Ydoi
10.3969/j.issn.1673-5374.2012.25.001subject
Has Abstractpub_date
2012-09-05 00:00:00pages
1925-30issue
25eissn
1673-5374issn
1876-7958pii
NRR-7-1925journal_volume
7pub_type
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