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Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats.

Abstract：

:Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Dawley rats were mated with male rats at a 1:1 ratio. Rats were administered 0, 5, 10 or 20 mg/kg acrylamide intragastrically from embryonic days 6-21. The gait scores were examined in pregnant rats in each group to analyze maternal toxicity. Eight weaning rats from each group were also euthanized on postnatal day 21 for follow-up studies. Nissl staining was used to observe histological change in the hippocampus. Immunohistochemistry was conducted to observe the condition of neurites, including dendrites and axons. Western blot assay was used to measure the expression levels of the specific nerve axon membrane protein, growth associated protein 43, and the presynaptic vesicle membrane specific protein, synaptophysin. The gait scores of gravid rats significantly increased, suggesting that acrylamide induced maternal motor dysfunction. The number of neurons, as well as expression of growth associated protein 43 and synaptophysin, was reduced with increasing acrylamide dose in postnatal day 21 weaning rats. These data suggest that acrylamide exerts dose-dependent toxic effects on the growth and development of hippocampal neurons of weaning rats.

journal_name

Neural Regen Res

journal_title

Neural regeneration research

authors

Lai SM,Gu ZT,Zhao MM,Li XX,Ma YX,Luo L,Liu J

doi

10.4103/1673-5374.217345

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1648-1654

issue

10

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2017_12_10_1648_217345

journal_volume

12

pub_type

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