当前位置： SCI文献检索 > Neural Regeneration Research期刊下所有文献 > Microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in dorsal root ganglia and neuropathic pain.

Microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in dorsal root ganglia and neuropathic pain.

Abstract：

:Schwann cell transplantation is a promising method to promote neural repair, and can be used for peripheral nerve protection and myelination. Microcapsule technology largely mitigates immune rejection of transplanted cells. We previously showed that microencapsulated olfactory ensheathing cells can reduce neuropathic pain and we hypothesized that microencapsulated Schwann cells can also inhibit neuropathic pain. Rat Schwann cells were cultured by subculture and then microencapsulated and were tested using a rat chronic constriction injury (CCI) neuropathic pain model. CCI rats were treated with Schwann cells or microencapsulated Schwann cells and were compared with sham and CCI groups. Mechanical withdrawal threshold and thermal withdrawal latency were assessed preoperatively and at 1, 3, 5, 7, 9, 11 and 14 days postoperatively. The expression of P2X3 receptors in L4-5 dorsal root ganglia of the different groups was detected by double-label immunofluorescence on day 14 after surgery. Compared with the chronic constriction injury group, mechanical withdrawal threshold and thermal withdrawal latency were higher, but the expression of P2X3 receptors was remarkably decreased in rats treated with Schwann cells and microencapsulated Schwann cells, especially in the rats transplanted with microencapsulated Schwann cells. The above data show that microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in L4-5 dorsal root ganglia and neuropathic pain.

journal_name

Neural Regen Res

journal_title

Neural regeneration research

authors

Zhang YL,Chen DJ,Yang BL,Liu TT,Li JJ,Wang XQ,Xue GY,Liu ZX

doi

10.4103/1673-5374.238715

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1961-1967

issue

11

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2018_13_11_1961_238715

journal_volume

13

pub_type

杂志文章

相关文献

Neural Regeneration Research文献大全
  • Recanalization of extracranial internal carotid artery occlusion: A 12-year retrospective study.

    abstract：:This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extracranial internal carotid artery occlusion. The study included 65 patients with extracranial internal carotid artery occlusion who u...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.23.011

    authors： Jiao L,Song G,Hua Y,Ma Y,Chen Y,Wang Y,Ling F

    更新日期：2013-08-15 00:00:00

  • Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is the most common form of dementia in the older population, however, the precise cause of the disease is unknown. The neuropathology is characterized by the presence of aggregates formed by amyloid-β (Aβ) peptide and phosphorylated tau; which is accompanied by progressive impairment of memory...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.238606

    authors： Tapia-Rojas C,Inestrosa NC

    更新日期：2018-10-01 00:00:00

  • Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury.

    abstract：:Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.221168

    authors： Pan B,Shi ZJ,Yan JY,Li JH,Feng SQ

    更新日期：2017-12-01 00:00:00

  • Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration.

    abstract：:Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.150706

    authors： Kou YH,Zhang PX,Wang YH,Chen B,Han N,Xue F,Zhang HB,Yin XF,Jiang BG

    更新日期：2015-01-01 00:00:00

  • Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury.

    abstract：:Traumatic brain injury (TBI) is a major health problem worldwide. Following primary mechanical insults, a cascade of secondary injuries often leads to further neural tissue loss. Thus far there is no cure to rescue the damaged neural tissue. Current therapeutic strategies primarily target the secondary injuries focusi...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.198964

    authors： Wurzelmann M,Romeika J,Sun D

    更新日期：2017-01-01 00:00:00

  • Spinal cord contusion.

    abstract：:Spinal cord injury is a major cause of disability with devastating neurological outcomes and limited therapeutic opportunities, even though there are thousands of publications on spinal cord injury annually. There are two major types of spinal cord injury, transaction of the spinal cord and spinal cord contusion. Both...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.131591

    authors： Ju G,Wang J,Wang Y,Zhao X

    更新日期：2014-04-15 00:00:00

  • Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke.

    abstract：:Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating n...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.265545

    authors： Zhang B,Saatman KE,Chen L

    更新日期：2020-03-01 00:00:00

  • Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain.

    abstract：:Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled b...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.219045

    authors： Li P,Li HX,Jiang HY,Zhu L,Wu HY,Li JT,Lai JH

    更新日期：2017-11-01 00:00:00

  • Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage.

    abstract：:Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.29.001

    authors： Chen G,Hu T,Li Q,Li J,Jia Y,Wang Z

    更新日期：2013-10-15 00:00:00

  • Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatment.

    abstract：:Abnormal TAR DNA-binding protein 43 (TDP-43) inclusion bodies can be detected in the degenerative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 express...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.35.003

    authors： Zheng M,Shi Y,Fan D

    更新日期：2013-12-15 00:00:00

  • Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.

    abstract：:A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibi...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.13.008

    authors： Xie Y,Liu Y,Shen W,Zhang B,Liu Q

    更新日期：2012-05-05 00:00:00

  • High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis.

    abstract：:Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among ankylosing spondylitis patients for 1 year aft...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.156988

    authors： Xue HX,Fu WY,Cui HD,Yang LL,Zhang N,Zhao LJ

    更新日期：2015-05-01 00:00:00

  • Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury.

    abstract：:The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine protein kinase (Akt) and c-Jun N-...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.170313

    authors： Jin M,Yang YW,Cheng WP,Lu JK,Hou SY,Dong XH,Liu SY

    更新日期：2015-11-01 00:00:00

  • Detrimental impact of hyperlipidemia on the peripheral nervous system: A novel target of medical epidemiological and fundamental research study.

    abstract：:Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve syst...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.3969/j.issn.1673-5374.2012.05.011

    authors： Wu S,Cao X,He R,Xiong K

    更新日期：2012-02-15 00:00:00

  • Human amnion tissue injected with human umbilical cord mesenchymal stem cells repairs damaged sciatic nerves in rats.

    abstract：:Human umbilical cord mesenchymal stem cells, incorporated into an amnion carrier tubes, were assessed for nerve regeneration potential in a rat nerve defect model. Damaged nerves were exposed to human amnion carriers containing either human umbilical cord mesenchymal stem cell (cell transplantation group) or saline (c...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.23.002

    authors： Li D,Wang C,Shan W,Zeng R,Fang Y,Wang P

    更新日期：2012-08-15 00:00:00

  • Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion.

    abstract：:Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expre...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.31.001

    authors： Xin H,Liang W,Mang J,Lin L,Guo N,Zhang F,Xu Z

    更新日期：2012-11-05 00:00:00

  • Changes of resting cerebral activities in subacute ischemic stroke patients.

    abstract：:This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majori...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.156977

    authors： Wu P,Zeng F,Li YX,Yu BL,Qiu LH,Qin W,Li J,Zhou YM,Liang FR

    更新日期：2015-05-01 00:00:00

  • Promises and pitfalls of immune-based strategies for Huntington's disease.

    abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.215245

    authors： Colpo GD,Stimming EF,Rocha NP,Teixeira AL

    更新日期：2017-09-01 00:00:00

  • The potential of neural transplantation for brain repair and regeneration following traumatic brain injury.

    abstract：:Traumatic brain injury is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery of patients in the clinic. Cell transplantation is a potential strategy to repair and regenerate the injured brain. This review article summarized recent de...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.169605

    authors： Sun D

    更新日期：2016-01-01 00:00:00

  • The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region.

    abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.18.003

    authors： Xu Q,Liu T,Chen S,Gao Y,Wang J,Qiao L,Liu J

    更新日期：2012-06-25 00:00:00

  • Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.

    abstract：:Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve re...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.197146

    authors： Li BH,Yang K,Wang X

    更新日期：2016-12-01 00:00:00

  • Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer's disease.

    abstract：:Tau hyperphosphorylation is a main cause of neuronal loss in Alzheimer's disease, which can be caused by many factors, including oxidative stress. The multifunctional protein p62, which exists in neurofibrillary tangles and causes aggregation of hyperphosphorylated tau, not only serves as a receptor in selective autop...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2012.17.004

    authors： Zheng X,Wang W,Liu R,Huang H,Zhang R,Sun L

    更新日期：2012-06-15 00:00:00

  • Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?

    abstract：:Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.253508

    authors： Romeo MA,Faggioni A,Cirone M

    更新日期：2019-09-01 00:00:00

  • Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils.

    abstract：:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive day...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.177735

    authors： Yoo KY,Kim IH,Cho JH,Ahn JH,Park JH,Lee JC,Tae HJ,Kim DW,Kim JD,Hong S,Won MH,Kang IJ

    更新日期：2016-02-01 00:00:00

  • Galanin and its receptor system promote the repair of injured sciatic nerves in diabetic rats.

    abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.191228

    authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

    更新日期：2016-09-01 00:00:00

  • Stem cell transplantation for spinal cord injury: a meta-analysis of treatment effectiveness and safety.

    abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.206653

    authors： Fan X,Wang JZ,Lin XM,Zhang L

    更新日期：2017-05-01 00:00:00

  • Emodin prevents hypoxic-ischemic neuronal injury: Involvement of the activin A pathway.

    abstract：:Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subje...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.15.002

    authors： Guo H,Shen X,Xu Y,Yuan J,Zhao D,Hu W

    更新日期：2013-05-25 00:00:00

  • Locus coeruleus-norepinephrine: basic functions and insights into Parkinson's disease.

    abstract：:The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeru...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.270297

    authors： Bari BA,Chokshi V,Schmidt K

    更新日期：2020-06-01 00:00:00

  • Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury.

    abstract：:Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

    journal_title：Neural regeneration research

    pub_type： 杂志文章,评审

    doi：10.4103/1673-5374.206633

    authors： Shultz RB,Zhong Y

    更新日期：2017-05-01 00:00:00

  • Transfer of the extensor indicis proprius branch of posterior interosseous nerve to reconstruct ulnar nerve and median nerve injured proximally: an anatomical study.

    abstract：:Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor function. This occurs even when the most meticulous microsurgical techniques or nerve grafts are used. Previous studies had proposed that nerve transfer was more effective than nerve grafting for nerve repair. Our...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.4103/1673-5374.199007

    authors： Wang PJ,Zhang Y,Zhao JJ,Zhou JP,Zuo ZC,Wu BB

    更新日期：2017-01-01 00:00:00