Abstract：
:A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in order to identify therapeutic targets to induce mammalian retina regeneration. We previously used pharmacological and genetic methods to inhibit gamma aminobutyric acid A (GABAA) receptors in undamaged zebrafish retinas and showed that such inhibition could induce initiation of retina regeneration, as measured by the dedifferentiation of MG and the appearance of MG-derived proliferating progenitor cells. Here, we show that inhibition of a pharmacologically distinct subset of GABAA receptors (GABAA-ρ) can also induce retina regeneration. Dual inhibition of both GABA receptor subtypes led to enhanced retina regeneration. Gene expression analyses indicate that inhibition of GABAA-ρ receptors induces a canonical retinal regenerative response. Our results support a model in which decreased levels of GABA, such as would occur after retinal cell death or damage, induce dedifferentiation of MG and the generation of proliferating progenitor cells during zebrafish retina regeneration. Animal experiments were approved by the Vanderbilt's Institutional Animal Care and Use Committee (Protocol M1800200) on January 29, 2019.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Kent MR,Kara N,Patton JGdoi
10.4103/1673-5374.286972subject
Has Abstractpub_date
2021-02-01 00:00:00pages
367-374issue
2eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_2_367_286972journal_volume
16pub_type
杂志文章abstract：:After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical t...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.14.008
更新日期：2012-05-15 00:00:00
abstract：:Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.282266
更新日期：2020-11-01 00:00:00
abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.224374
更新日期：2018-01-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.147929
更新日期：2014-12-01 00:00:00
abstract：:Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models of deafness. However, to the best of our knowledge, there is no report on the establishment of a rat deafness model through the combined application of aminoglycosides and loop diuretics. The aim of this study was to use single...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.153704
更新日期：2015-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.184490
更新日期：2016-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.238606
更新日期：2018-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.150716
更新日期：2015-01-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.249215
更新日期：2019-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.08.006
更新日期：2012-03-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.11.002
更新日期：2013-04-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.30.005
更新日期：2012-10-25 00:00:00
abstract：:Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.301024
更新日期：2021-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.34.003
更新日期：2013-12-05 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.219025
更新日期：2017-11-01 00:00:00
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journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2013.05.012
更新日期：2013-02-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.29.006
更新日期：2012-10-15 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.33.003
更新日期：2013-11-25 00:00:00
abstract：:[This corrects the article on p. 1386 in vol. 10, PMID: 26604888.]. ...
journal_title：Neural regeneration research
pub_type： 已发布勘误
doi：10.4103/1673-5374.187069
更新日期：2016-07-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.215245
更新日期：2017-09-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.300323
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.250578
更新日期：2019-06-01 00:00:00
abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.253535
更新日期：2019-08-01 00:00:00
abstract：:Fimbria-fornix transection induces both exogenous and endogenous neural stem cells to differentiate into neurons in the hippocampus. This indicates that the denervated hippocampus provides an environment for neuronal differentiation of neural stem cells. However, the pathways and mechanisms in this process are still u...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.180744
更新日期：2016-04-01 00:00:00
abstract：:In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent cla...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.293132
更新日期：2021-04-01 00:00:00
abstract：:Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupu...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.193238
更新日期：2016-10-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.150706
更新日期：2015-01-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 已发布勘误
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更新日期：2017-06-01 00:00:00
abstract：:Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer's disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this review, we evaluated the ways in which modern imaging techniques such a...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.286957
更新日期：2021-01-01 00:00:00
