Abstract:
:New Zealand rabbits were randomly divided into an ischemia group (occlusion of the abdominal aorta for 60 minutes), an ischemia-reperfusion group (occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group. Two-dimensional gel electrophoresis detected 49 differentially expressed proteins in spinal cord tissue from the ischemia and ischemia/ reperfusion groups and 23 of them were identified by mass spectrometry. In the ischemia group, the expression of eight proteins was up regulated, and that of the remaining four proteins was down regulated. In the ischemia/reperfusion group, the expression of four proteins was up regulated, and that of two proteins was down regulated. In the sham-surgery group, only one protein was detected. In the ischemia and ischemia/reperfusion groups, four proteins overlapped between groups with the same differential expression, including three that were up regulated and one down regulated. These proteins were related to energy metabolism, cell defense, inflammatory mechanism and cell signaling.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Gao Q,Liang Y,Yang X,Liu G,Li X,Zhu B,Liu J,Yang M,Xia W,Dong J,Jiao Jdoi
10.3969/j.issn.1673-5374.2012.20.002subject
Has Abstractpub_date
2012-07-15 00:00:00pages
1534-9issue
20eissn
1673-5374issn
1876-7958pii
NRR-7-1534journal_volume
7pub_type
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