Epidural electrical stimulation effectively restores locomotion function in rats with complete spinal cord injury.

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:Growth arrest-specific 5 (GAS5) is an anti-oncogene that has been extensively studied in tumors. However, research on GAS5 in the context of nervous system disease is rare at present. This study aimed to investigate the role of the long non-coding RNA GAS5 in rat pheochromocytoma cells (PC12 cells). GAS5-overexpressin...

journal_title：Neural regeneration research

authors： Zhao HY,Zhang ST,Cheng X,Li HM,Zhang L,He H,Qin JB,Zhang WY,Sun Y,Jin GH

更新日期：2019-12-01 00:00:00

abstract：:We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolle...

journal_title：Neural regeneration research

authors： Lee AY,Jang SH,Yeo SS,Lee E,Cho YW,Son SM

更新日期：2013-02-15 00:00:00

abstract：:Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, ther...

journal_title：Neural regeneration research

authors： Zhang W,Tian T,Gong SX,Huang WQ,Zhou QY,Wang AP,Tian Y

更新日期：2021-01-01 00:00:00

abstract：:The reconstruction of nerve continuity after traumatic nerve injury is the gold standard in hand surgery. Immediate, tension-free, end-to-end nerve suture ensures the best prognosis. The recovery is mostly promising; however, in a few cases, insufficient outcomes in motor or sensory function are observed. Intra- and e...

journal_title：Neural regeneration research

authors： Krzesniak NE,Sarnowska A,Figiel-Dabrowska A,Osiak K,Domanska-Janik K,Noszczyk BH

更新日期：2021-05-01 00:00:00

abstract：:Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in prolines, a...

journal_title：Neural regeneration research

authors： Caminati G,Procacci P

更新日期：2020-12-01 00:00:00

abstract：:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

journal_title：Neural regeneration research

authors： Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

更新日期：2021-07-01 00:00:00

abstract：:The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic...

journal_title：Neural regeneration research

authors： Wang W,Townes-Anderson E

更新日期：2016-07-01 00:00:00

abstract：:Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the t...

journal_title：Neural regeneration research

authors： Zhou YJ,Liu JM,Wei SM,Zhang YH,Qu ZH,Chen SB

更新日期：2015-08-01 00:00:00

abstract：:Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin (8-(β-D-Glucopyranosyl-7-h...

journal_title：Neural regeneration research

authors： Wu M,Zhao G,Yang X,Peng C,Zhao J,Liu J,Li R,Gao Z

更新日期：2014-03-15 00:00:00

abstract：:Genome-wide studies have reported that Parkinson's disease is associated with abnormal expression of various growth factors. In this study, male C57BL/6 mice aged 10 weeks were used to establish Parkinson's disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 d...

journal_title：Neural regeneration research

authors： Wang AQ,Kong LN,Meng MZ,Zhao XH,Chen S,Wang XT

更新日期：2019-08-01 00:00:00

abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

journal_title：Neural regeneration research

authors： Jeanneret V,Yepes M

更新日期：2017-03-01 00:00:00

abstract：:Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...

journal_title：Neural regeneration research

authors： Morrison BE

更新日期：2016-06-01 00:00:00

abstract：:Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric...

journal_title：Neural regeneration research

authors： Zhang Y,Shao G,Zhang W,Li S,Niu J,Hu D,Yang M,Ji X

更新日期：2013-11-15 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare system...

journal_title：Neural regeneration research

authors： Ferreira S,Raimundo AF,Menezes R,Martins IC

更新日期：2021-06-01 00:00:00

abstract：:Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apopto...

journal_title：Neural regeneration research

authors： Wang Z,Xue R,Lei X,Lv J,Wu G,Li W,Xue L,Lei X,Zhao H,Gao H,Wei X

更新日期：2012-10-25 00:00:00

abstract：:Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and J...

journal_title：Neural regeneration research

authors： Zhang YS,Sun AP,Chen L,Dong RF,Zhong YF,Zhang J

更新日期：2015-01-01 00:00:00

abstract：:Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelo...

journal_title：Neural regeneration research

authors： Lin E,Long H,Li G,Lei W

更新日期：2013-12-25 00:00:00

abstract：:Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve syst...

journal_title：Neural regeneration research

authors： Wu S,Cao X,He R,Xiong K

更新日期：2012-02-15 00:00:00

abstract：:The present study recruited 193 patients with ischemic cerebrovascular disease from Inpatient and Outpatient Departments at the Affiliated Hospital of Qingdao University Medical College, China from August 2008 to May 2010, as well as 120 healthy volunteers from the Medical Examination Center at the Affiliated Hospital...

journal_title：Neural regeneration research

authors： Wang H,Song Y,Zhang C,Zhan J,Zhang R,Wang H

更新日期：2012-03-05 00:00:00

abstract：:Fractional anisotropy values in diffusion tensor imaging can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia o...

journal_title：Neural regeneration research

authors： Jing G,Yao X,Li Y,Xie Y,Li WX,Liu K,Jing Y,Li B,Lv Y,Ma B

更新日期：2014-01-15 00:00:00

abstract：:Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effect. Spinal cord inju...

journal_title：Neural regeneration research

authors： Hao J,Li B,Duan HQ,Zhao CX,Zhang Y,Sun C,Pan B,Liu C,Kong XH,Yao X,Feng SQ

更新日期：2017-06-01 00:00:00

abstract：:Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...

journal_title：Neural regeneration research

authors： Chen G,Hu T,Li Q,Li J,Jia Y,Wang Z

更新日期：2013-10-15 00:00:00

abstract：:In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...

journal_title：Neural regeneration research

authors： Yu XH,Wu JX,Chen L,Gu YD

更新日期：2020-07-01 00:00:00

abstract：:The Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of ...

journal_title：Neural regeneration research

authors： Cai X,Yang L,Zhou J,Zhu D,Guo Q,Chen Z,Chen S,Zhou L

更新日期：2013-02-25 00:00:00

abstract：:We have previously shown that induction of ketosis by ketogenic diet (KD) conveyed neuroprotection following spinal cord injury in rodent models, however, clinical translation may be limited by the slow raise of ketone levels when applying KD in the acute post-injury period. Thus we investigated the use of exogenous k...

journal_title：Neural regeneration research

authors： Tan BT,Jiang H,Moulson AJ,Wu XL,Wang WC,Liu J,Plunet WT,Tetzlaff W

更新日期：2020-10-01 00:00:00

abstract：:Hyperhomocysteinemia is an important risk factor for preeclampsia-eclampsia. This study established a pregnant rat model of hyperhomocysteinemia, in which blood plasma homocysteine concentrations were twice or three times greater than that of normal pregnant rats. TUNEL revealed an increase in the number of apoptotic ...

journal_title：Neural regeneration research

authors： Wang J,Ge J,Yang L,Zhang H,Li X,Xue D

更新日期：2012-10-05 00:00:00

abstract：:Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in bra...

journal_title：Neural regeneration research

authors： Filosa S,Di Meo F,Crispi S

更新日期：2018-12-01 00:00:00

abstract：:The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...

journal_title：Neural regeneration research

authors： Yuan XN,Liang WD,Zhou FH,Li HT,Zhang LX,Zhang ZQ,Li JJ

更新日期：2019-02-01 00:00:00

abstract：:A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarin...

journal_title：Neural regeneration research

authors： Chen M,Wang J,Ming C

更新日期：2012-03-25 00:00:00