Abstract:
:Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in prolines, abnormally aggregate in tangles in the brain leading to progressive loss of neurons. In this review, we present an overview linking the studies on the implication of the peptidyl-prolyl isomerase domain of immunophilins, and notably FKBP12, to a variety of neurodegenerative diseases, focusing on the molecular origin of such a role. The involvement of FKBP12 dysregulation in the aberrant aggregation of disordered proteins pinpoints this protein as a possible therapeutic target and, at the same time, as a predictive biomarker for early diagnosis in neurodegeneration, calling for the development of reliable, fast and cost-effective detection methods in body fluids for community-based screening campaigns.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Caminati G,Procacci Pdoi
10.4103/1673-5374.284980subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2195-2202issue
12eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2020_15_12_2195_284980journal_volume
15pub_type
杂志文章,评审abstract::Human umbilical cord mesenchymal stem cells, incorporated into an amnion carrier tubes, were assessed for nerve regeneration potential in a rat nerve defect model. Damaged nerves were exposed to human amnion carriers containing either human umbilical cord mesenchymal stem cell (cell transplantation group) or saline (c...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.23.002
更新日期:2012-08-15 00:00:00
abstract::Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we us...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.228728
更新日期:2018-03-01 00:00:00
abstract::There is currently very little research regarding the dynamics of the subcellular degenerative events that occur in the central nervous system in response to injury. To date, multi-photon excitation has been primarily used for imaging applications; however, it has been recently used to selectively disrupt neural struc...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.206644
更新日期:2017-05-01 00:00:00
abstract::Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.172319
更新日期:2015-12-01 00:00:00
abstract::Three male patients were diagnosed with new cortical infarctions of the right parietal lobe on the basis of head magnetic resonance imaging; high-intensity signals indicating lesions in the right parietal lobe were noted on diffusion-weighted images at admission. Two of them presented with left hand weakness, and one ...
journal_title:Neural regeneration research
pub_type:
doi:10.3969/j.issn.1673-5374.2012.12.011
更新日期:2012-04-25 00:00:00
abstract::Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.266914
更新日期:2020-04-01 00:00:00
abstract::Genome-wide studies have reported that Parkinson's disease is associated with abnormal expression of various growth factors. In this study, male C57BL/6 mice aged 10 weeks were used to establish Parkinson's disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 d...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.253527
更新日期:2019-08-01 00:00:00
abstract::Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.230294
更新日期:2018-04-01 00:00:00
abstract::Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were trea...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.300456
更新日期:2021-06-01 00:00:00
abstract::Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote t...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.262596
更新日期:2019-12-01 00:00:00
abstract::The relative frequencies of different subtypes of limb-girdle muscular dystrophies vary widely among different populations. We estimated the percentage of limb-girdle muscular dystrophy subtypes in Chinese people based on 68 patients with limb-girdle muscular dystrophy from the Myology Clinic, Neurology Department, Fi...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.20.010
更新日期:2013-07-15 00:00:00
abstract::The present study showed that the latency of rats moving on a vertical grid was significantly prolonged, and the number of rats sliding down from the declined plane was increased remarkably, in rotenone-induced Parkinson's disease model rats compared with control rats. The moving latency recovered to normal levels, bu...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.05.001
更新日期:2012-02-15 00:00:00
abstract::[This corrects the article on p. 770 in vol. 12, PMID: 28616034.]. ...
journal_title:Neural regeneration research
pub_type: 已发布勘误
doi:10.4103/1673-5374.208598
更新日期:2017-06-01 00:00:00
abstract::Neuropathic pain after spinal cord injury (SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy; nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the a...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.259624
更新日期:2019-11-01 00:00:00
abstract::Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to gene...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.23.001
更新日期:2013-08-15 00:00:00
abstract::Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.253535
更新日期:2019-08-01 00:00:00
abstract::Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low l...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145337
更新日期:2014-11-01 00:00:00
abstract::The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of adaptation mechanisms (ion currents) in modulating neuronal dynamic range were numericall...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.202931
更新日期:2017-03-01 00:00:00
abstract::Generation of neurons in the brains of adult birds has been studied extensively in the telencephalon of song birds and few studies are reported on the distribution of PCNA and DCX in the telencephalon of adult non-song learning birds. We report here on adult neurogenesis throughout the brains of two breeds of adult do...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.211187
更新日期:2017-07-01 00:00:00
abstract::Fimbria-fornix transection induces both exogenous and endogenous neural stem cells to differentiate into neurons in the hippocampus. This indicates that the denervated hippocampus provides an environment for neuronal differentiation of neural stem cells. However, the pathways and mechanisms in this process are still u...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.180744
更新日期:2016-04-01 00:00:00
abstract::Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.184449
更新日期:2016-06-01 00:00:00
abstract::Insulin-like growth factor 1 (IGF-1) is a potential nutrient for nerve repair. However, it is impractical as a therapy because of its limited half-life, rapid clearance, and limited target specificity. To achieve targeted and long-lasting treatment, we investigated the addition of a binding structure by fusing a colla...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.226400
更新日期:2018-02-01 00:00:00
abstract::Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.165520
更新日期:2015-09-01 00:00:00
abstract:Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.266915
更新日期:2020-04-01 00:00:00
abstract::For decades, clinicians have developed medications and therapies to alleviate the symptoms of Parkinson's disease, but no treatment currently can slow or even stop the progression of this localized neurodegeneration. Fortunately, sparked by the genetic revolution, stem cell reprogramming research and the advancing cap...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.264446
更新日期:2020-01-01 00:00:00
abstract::Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.202924
更新日期:2017-03-01 00:00:00
abstract::End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps, compared to repairs with a graft. However, grafts are typically used to enable a tension-free repair for moderate to large gaps, as excessive tension can cause repairs to fail and catastrophically impede recover...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.251338
更新日期:2019-07-01 00:00:00
abstract::In this study, we hypothesized that an increase in integrin αvβ3 and its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning with bilateral common carotid artery occlusion for 5 minutes in C57BL/6J mice. This was followed by isc...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.182703
更新日期:2016-05-01 00:00:00
abstract::Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.07.009
更新日期:2013-03-05 00:00:00
abstract::Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.150706
更新日期:2015-01-01 00:00:00