Abstract:
:Fimbria-fornix transection induces both exogenous and endogenous neural stem cells to differentiate into neurons in the hippocampus. This indicates that the denervated hippocampus provides an environment for neuronal differentiation of neural stem cells. However, the pathways and mechanisms in this process are still unclear. Seven days after fimbria fornix transection, our reverse transcription polymerase chain reaction, western blot assay, and enzyme linked immunosorbent assay results show a significant increase in ciliary neurotrophic factor mRNA and protein expression in the denervated hippocampus. Moreover, neural stem cells derived from hippocampi of fetal (embryonic day 17) Sprague-Dawley rats were treated with ciliary neurotrophic factor for 7 days, with an increased number of microtubule associated protein-2-positive cells and decreased number of glial fibrillary acidic protein-positive cells detected. Our results show that ciliary neurotrophic factor expression is up-regulated in the denervated hippocampus, which may promote neuronal differentiation of neural stem cells in the denervated hippocampus.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang L,Han X,Cheng X,Tan XF,Zhao HY,Zhang XHdoi
10.4103/1673-5374.180744subject
Has Abstractpub_date
2016-04-01 00:00:00pages
597-603issue
4eissn
1673-5374issn
1876-7958pii
NRR-11-597journal_volume
11pub_type
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