Abstract:
:Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Peng CG,Zhang SQ,Wu MF,Lv Y,Wu DK,Yang Q,Gu Rdoi
10.4103/1673-5374.165520subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1477-82issue
9eissn
1673-5374issn
1876-7958pii
NRR-10-1477journal_volume
10pub_type
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