Mild hypothermia for treatment of diffuse axonal injury: a quantitative analysis of diffusion tensor imaging.

abstract：:Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of...

journal_title：Neural regeneration research

authors： Zhang B,He Q,Li YY,Li C,Bai YL,Hu YS,Zhang F

更新日期：2015-12-01 00:00:00

abstract：:Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties. We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury. In this study, rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1, 7, a...

journal_title：Neural regeneration research

authors： Zhao ZK,Yu HL,Liu B,Wang H,Luo Q,Ding XG

更新日期：2016-08-01 00:00:00

abstract：:Interleukin-1α and interleukin-1β aggravate neuronal injury by mediating the inflammatory reaction following ischemic/hypoxic brain injury. It remains unclear whether interleukin-1α and interleukin-1β are released by microglia or astrocytes. This study prepared hippocampal slices that were subsequently subjected to ox...

journal_title：Neural regeneration research

authors： Wang H,Guo W,Liu H,Zeng R,Lu M,Chen Z,Xiao Q

更新日期：2013-05-05 00:00:00

abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

journal_title：Neural regeneration research

authors： Wang X,Wu H,Xue G,Hou Y

更新日期：2012-09-05 00:00:00

abstract：:Gynostemma (G.) pentaphyllum (Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum (GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 6-...

journal_title：Neural regeneration research

authors： Park HJ,Zhao TT,Kim SH,Lee CK,Hwang BY,Lee KE,Lee MK

更新日期：2020-02-01 00:00:00

abstract：:Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote t...

journal_title：Neural regeneration research

authors： Zhang ZY,Yang J,Fan ZH,Wang DL,Wang YY,Zhang T,Yu LM,Yu CY

更新日期：2019-12-01 00:00:00

abstract：:Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...

journal_title：Neural regeneration research

authors： Zhao YD,Zhang QB,Chen H,Fei XF,Shen YT,Ji XY,Ma JW,Wang AD,Dong J,Lan Q,Huang Q

更新日期：2017-11-01 00:00:00

abstract：:Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold mater...

journal_title：Neural regeneration research

authors： Zhang PX,Han N,Kou YH,Zhu QT,Liu XL,Quan DP,Chen JG,Jiang BG

更新日期：2019-01-01 00:00:00

abstract：:Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was establi...

journal_title：Neural regeneration research

authors： Lv SQ,Wu W

更新日期：2021-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation (i.e., miR-142-3p, miR-142-5p, and miR-146a) are altere...

journal_title：Neural regeneration research

authors： Wang WX,Prajapati P,Vekaria HJ,Spry M,Cloud AL,Sullivan PG,Springer JE

更新日期：2021-03-01 00:00:00

abstract：:The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that el...

journal_title：Neural regeneration research

authors： Sacchetti M,Lambiase A

更新日期：2017-08-01 00:00:00

abstract：:No recommended guidelines currently exist for the therapeutic concentration or dose of botulinum toxin type A (BTXA) injected into the muscle to treat limb spasticity. Therefore, in this randomized controlled trial, we explored the safety and efficacy of two concentrations and two doses of BTXA in the treatment of spa...

journal_title：Neural regeneration research

authors： Li J,Zhang R,Cui BL,Zhang YX,Bai GT,Gao SS,Li WJ

更新日期：2017-09-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown. In this study, a rat model for vascular dementia was establis...

journal_title：Neural regeneration research

authors： Zhang XQ,Li L,Huo JT,Cheng M,Li LH

更新日期：2018-08-01 00:00:00

abstract：:The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

journal_title：Neural regeneration research

authors： Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

更新日期：2016-11-01 00:00:00

abstract：:Neurotoxicity induced by stress, radiation, chemicals, or metabolic diseases, is commonly associated with excitotoxicity, oxidative stress, and neuroinflammation. The pathological process of neurotoxicity induces neuronal death, interrupts synaptic plasticity in the brain, and is similar to that of diverse neurodegene...

journal_title：Neural regeneration research

authors： Kim J,Lee S,Kang S,Kim SH,Kim JC,Yang M,Moon C

更新日期：2017-10-01 00:00:00

abstract：:Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbil...

journal_title：Neural regeneration research

authors： Yao L,He C,Zhao Y,Wang J,Tang M,Li J,Wu Y,Ao L,Hu X

更新日期：2013-02-15 00:00:00

abstract：:Neuropathic pain after spinal cord injury (SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy; nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the a...

journal_title：Neural regeneration research

authors： Batista CM,Mariano ED,Dale CS,Cristante AF,Britto LR,Otoch JP,Teixeira MJ,Morgalla M,Lepski G

更新日期：2019-11-01 00:00:00

abstract：:In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...

journal_title：Neural regeneration research

authors： Li Q,Zhai Q,Geng J,Zheng H,Chen F,Kong J,Zhang C

更新日期：2012-08-05 00:00:00

abstract：:This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based m...

journal_title：Neural regeneration research

authors： Tan L,Zhang L,Qi R,Lu G,Li L,Liu J,Li W

更新日期：2013-09-15 00:00:00

abstract：:Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infar...

journal_title：Neural regeneration research

authors： He ZP,Lu H

更新日期：2015-07-01 00:00:00

abstract：:Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low l...

journal_title：Neural regeneration research

authors： So KF,Leung MC,Cui Q

更新日期：2014-11-01 00:00:00

abstract：:Epithelial-specific ETS-1 (ESE1), a member of the ETS transcription factor family, is widely expressed in multiple tissues and performs various functions in inflammation. During neuroinflammation, ESE1 promotes neuronal apoptosis; however, the expression and biological functions of ESE1 remain unclear after cerebral i...

journal_title：Neural regeneration research

authors： Yu HL,Wang LZ,Zhang LL,Chen BL,Zhang HJ,Li YP,Xiao GD,Chen YZ

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...

journal_title：Neural regeneration research

authors： Ding S

更新日期：2014-12-01 00:00:00

abstract：:The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil(®) (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressu...

journal_title：Neural regeneration research

authors： Liu H,Ni Z,Chen Y,Wang D,Qi Y,Zhang Q,Wang S

更新日期：2012-04-05 00:00:00

abstract：:The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeru...

journal_title：Neural regeneration research

authors： Bari BA,Chokshi V,Schmidt K

更新日期：2020-06-01 00:00:00

abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

journal_title：Neural regeneration research

authors： Tanokashira D,Fukuokaya W,Taguchi A

更新日期：2019-08-01 00:00:00

abstract：:Indirubin-3'-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. Here, we found that indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), an...

journal_title：Neural regeneration research

authors： Zhang SG,Wang XS,Zhang YD,Di Q,Shi JP,Qian M,Xu LG,Lin XJ,Lu J

更新日期：2016-06-01 00:00:00

abstract：:The optic nerve is a viscoelastic solid-like biomaterial. Its normal stress relaxation and creep properties enable the nerve to resist constant strain and protect it from injury. We hypothesized that stress relaxation and creep properties of the optic nerve change after injury. More-over, human brain-derived neurotrop...

journal_title：Neural regeneration research

authors： Lv XM,Liu Y,Wu F,Yuan Y,Luo M

更新日期：2016-04-01 00:00:00

abstract：:Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear. In this study, we established a model of neurodegenerative disease using PC12 cytotoxic injury induced by glutamate. The cells were treated with 20 mM glutamate in the abs...

journal_title：Neural regeneration research

authors： Liu Y,Liu L,Ying XX,Wei WJ,Han C,Liu Y,Han CH,Leng AJ,Ma JY,Liu J

更新日期：2017-08-01 00:00:00