Abstract:
:Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang B,Saatman KE,Chen Ldoi
10.4103/1673-5374.265545subject
Has Abstractpub_date
2020-03-01 00:00:00pages
416-424issue
3eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2020_15_3_416_265545journal_volume
15pub_type
杂志文章,评审abstract::Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment...
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
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