Influence of immobilization and sensory re-education on the sensory recovery after reconstruction of digital nerves with direct suture or muscle-in-vein conduits.

abstract：:An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However, most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also ...

journal_title：Neural regeneration research

authors： Jiang JP,Niu XG,Dai C,Ma K,Xu HY,Cheng SX,Zhang ZW,Duan F,Zhu X,Wang YT,Chen XY,Zhang S

更新日期：2019-06-01 00:00:00

abstract：:Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

journal_title：Neural regeneration research

authors： Shultz RB,Zhong Y

更新日期：2017-05-01 00:00:00

abstract：:A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarin...

journal_title：Neural regeneration research

authors： Chen M,Wang J,Ming C

更新日期：2012-03-25 00:00:00

abstract：:Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer's disease cell model. swAPP695-HEK293 cells were treated with 0, 0.5, 1, 2, 5, and 10 μM curcumin for ...

journal_title：Neural regeneration research

authors： Liu HY,Fu X,Li YF,Li XL,Ma ZY,Zhang Y,Gao QC

更新日期：2019-09-01 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：:Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achille...

journal_title：Neural regeneration research

authors： Jielile J,Aibai M,Sabirhazi G,Shawutali N,Tangkejie W,Badelhan A,Nuerduola Y,Satewalede T,Buranbai D,Hunapia B,Jialihasi A,Bai J,Kizaibek M

更新日期：2012-12-15 00:00:00

abstract：:As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute isch...

journal_title：Neural regeneration research

authors： Huai Y,Dong Y,Xu J,Meng N,Song C,Li W,Lv P

更新日期：2013-07-05 00:00:00

abstract：:The study aims to confirm the neuroregenerative effects of bacterial melanin (BM) on central nervous system injury using a special staining method based on the detection of Ca(2+)-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor corte...

journal_title：Neural regeneration research

authors： Petrosyan TR,Ter-Markosyan AS,Hovsepyan AS

更新日期：2016-07-01 00:00:00

abstract：:Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to gene...

journal_title：Neural regeneration research

authors： Gu Z,Sun Y,Liu K,Wang F,Zhang T,Li Q,Shen L,Zhou L,Dong L,Shi N,Zhang Q,Zhang W,Zhao M,Sun X

更新日期：2013-08-15 00:00:00

abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

journal_title：Neural regeneration research

authors： Wang X,Wu H,Xue G,Hou Y

更新日期：2012-09-05 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...

journal_title：Neural regeneration research

authors： Colpo GD,Stimming EF,Rocha NP,Teixeira AL

更新日期：2017-09-01 00:00:00

abstract：:Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hy...

journal_title：Neural regeneration research

authors： Biazar E,Keshel SH,Pouya M

更新日期：2013-09-25 00:00:00

abstract：:Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding; however, the interplay between these two factors is less studied. While previous work has shown that the biochemical identity of the matrix can alter the outgrowth of neurites in response to neurotrophins, the im...

journal_title：Neural regeneration research

authors： Madl CM,Heilshorn SC

更新日期：2015-04-01 00:00:00

abstract：:Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substan...

journal_title：Neural regeneration research

authors： Shaimardanova AA,Solovyeva VV,Chulpanova DS,James V,Kitaeva KV,Rizvanov AA

更新日期：2020-04-01 00:00:00

abstract：:The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...

journal_title：Neural regeneration research

authors： Yang B,Wang PB,Mu N,Ma K,Wang S,Yang CY,Huang ZB,Lai Y,Feng H,Yin GF,Chen TN,Hu CS

更新日期：2021-09-01 00:00:00

abstract：:One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage a...

journal_title：Neural regeneration research

authors： Lara-Celador I,Goñi-de-Cerio F,Alvarez A,Hilario E

更新日期：2013-03-15 00:00:00

abstract：:Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer's disease, but its physiological function remains poor...

journal_title：Neural regeneration research

authors： Bernabeu-Zornoza A,Coronel R,Palmer C,Monteagudo M,Zambrano A,Liste I

更新日期：2019-12-01 00:00:00

abstract：:Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

journal_title：Neural regeneration research

authors： Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation (i.e., miR-142-3p, miR-142-5p, and miR-146a) are altere...

journal_title：Neural regeneration research

authors： Wang WX,Prajapati P,Vekaria HJ,Spry M,Cloud AL,Sullivan PG,Springer JE

更新日期：2021-03-01 00:00:00

abstract：:Clinical studies have shown that hyperbaric oxygen therapy improves motor function in patients with spinal cord injury. In the present study, we explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. We established an acute sp...

journal_title：Neural regeneration research

authors： Wang Y,Zhang S,Luo M,Li Y

更新日期：2014-12-15 00:00:00

abstract：:Chalcone is a plant metabolite widely found in fruits, vegetables, spices and tea, and has anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidation activities, as well as many other pharmacological and biological effects. Our team has shown that its analogs have antioxidant activity, and oxida...

journal_title：Neural regeneration research

authors： Wang L,Chen HC,Yang X,Tao JJ,Liang G,Wu JZ,Wu WC,Wang Y,Song ZM,Zhang X

更新日期：2018-09-01 00:00:00

abstract：:Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerati...

journal_title：Neural regeneration research

authors： Fornaro M,Giovannelli A,Foggetti A,Muratori L,Geuna S,Novajra G,Perroteau I

更新日期：2020-09-01 00:00:00

abstract：:Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse...

journal_title：Neural regeneration research

authors： Mao HF,Xie J,Chen JQ,Tang CF,Chen W,Zhou BC,Chen R,Qu HL,Wu CZ

更新日期：2017-04-01 00:00:00

abstract：:This study investigated the effects of small interfering RNA (siRNA)-mediated silencing of chemokine receptor 4 (CXCR4) on the invasion capacity of human neuroblastoma cell line SH-SY5Y in vitro. Three siRNAs targeting CXCR4 were chemically synthesized and individually transfected into SH-SY5Y cells. Expression of CXC...

journal_title：Neural regeneration research

authors： Chen X,Zhu Y,Han L,Lu H,Hao X,Dong Q

更新日期：2014-05-15 00:00:00

abstract：:TMP269 is a selective class IIA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. ...

journal_title：Neural regeneration research

authors： Su L,Liang D,Kuang SY,Dong Q,Han X,Wang Z

更新日期：2020-02-01 00:00:00

abstract：:Paired immunoglobulin-like receptor B (PirB) is a functional receptor of myelin-associated inhibitors for axonal regeneration and synaptic plasticity in the central nervous system, and thus suppresses nerve regeneration. The regulatory effect of PirB on injured nerves has received a lot of attention. To better underst...

journal_title：Neural regeneration research

authors： Peng WS,Qi C,Zhang H,Gao ML,Wang H,Ren F,Li XQ

更新日期：2015-07-01 00:00:00

abstract：:Neuropathic pain after spinal cord injury (SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy; nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the a...

journal_title：Neural regeneration research

authors： Batista CM,Mariano ED,Dale CS,Cristante AF,Britto LR,Otoch JP,Teixeira MJ,Morgalla M,Lepski G

更新日期：2019-11-01 00:00:00

abstract：:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...

journal_title：Neural regeneration research

authors： Ren C,Ji YQ,Liu H,Wang Z,Wang JH,Zhang CY,Guan LN,Yin PY

更新日期：2019-07-01 00:00:00

abstract：:Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve tran...

journal_title：Neural regeneration research

authors： Yu F,Yu YL,Niu SP,Zhang PX,Yin XF,Han N,Zhang YJ,Zhang DY,Kou YH,Jiang BG

更新日期：2019-04-01 00:00:00