Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke.

abstract：:The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...

journal_title：Neural regeneration research

authors： Li XJ,Li CK,Wei LY,Lu N,Wang GH,Zhao HG,Li DL

更新日期：2015-06-01 00:00:00

abstract：:Genome-wide studies have reported that Parkinson's disease is associated with abnormal expression of various growth factors. In this study, male C57BL/6 mice aged 10 weeks were used to establish Parkinson's disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 d...

journal_title：Neural regeneration research

authors： Wang AQ,Kong LN,Meng MZ,Zhao XH,Chen S,Wang XT

更新日期：2019-08-01 00:00:00

abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

journal_title：Neural regeneration research

authors： Wang X,Wu H,Xue G,Hou Y

更新日期：2012-09-05 00:00:00

abstract：:Gynostemma (G.) pentaphyllum (Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum (GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 6-...

journal_title：Neural regeneration research

authors： Park HJ,Zhao TT,Kim SH,Lee CK,Hwang BY,Lee KE,Lee MK

更新日期：2020-02-01 00:00:00

abstract：:The present study analyzed changes in Wnt3a expression during differentiation of adipose-derived stem cells into cholinergic neurons. Immunocytochemistry and immunofluorescence revealed significantly increased nestin, neuron-specific enolase, microtubule-associated protein 2, and choline acetyltransferase expression i...

journal_title：Neural regeneration research

authors： Liu B,Deng C,Zhang Y,Zhang J

更新日期：2012-07-05 00:00:00

abstract：:Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicit...

journal_title：Neural regeneration research

authors： Lei T,Li H,Fang Z,Lin J,Wang S,Xiao L,Yang F,Liu X,Zhang J,Huang Z,Liao W

更新日期：2014-02-01 00:00:00

abstract：:The present study showed that the latency of rats moving on a vertical grid was significantly prolonged, and the number of rats sliding down from the declined plane was increased remarkably, in rotenone-induced Parkinson's disease model rats compared with control rats. The moving latency recovered to normal levels, bu...

journal_title：Neural regeneration research

authors： Li C,Chen X,Zhang N,Song Y,Mu Y

更新日期：2012-02-15 00:00:00

abstract：:Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the ri...

journal_title：Neural regeneration research

authors： Du L,Yang M,Wan L,Wang XH,Li ST

更新日期：2016-10-01 00:00:00

abstract：:Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric...

journal_title：Neural regeneration research

authors： Zhang Y,Shao G,Zhang W,Li S,Niu J,Hu D,Yang M,Ji X

更新日期：2013-11-15 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...

journal_title：Neural regeneration research

authors： Yu XH,Wu JX,Chen L,Gu YD

更新日期：2020-07-01 00:00:00

abstract：:Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating n...

journal_title：Neural regeneration research

authors： Zhang B,Saatman KE,Chen L

更新日期：2020-03-01 00:00:00

abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...

journal_title：Neural regeneration research

authors： Pan S,Wan J,Liu S,Zhang S,Xiong H,Zhou J,Xiong W,Yu K,Fu Y

更新日期：2013-06-15 00:00:00

abstract：:After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical t...

journal_title：Neural regeneration research

authors： Wang H,Si L,Li X,Deng W,Yang H,Yang Y,Fu Y

更新日期：2012-05-15 00:00:00

abstract：:Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...

journal_title：Neural regeneration research

authors： Morrison BE

更新日期：2016-06-01 00:00:00

abstract：:Single-chain variable domain fragment (scFv) 637 is an antigen-specific scFv of myasthenia gravis. In this study, scFv and human serum albumin genes were conjugated and the fusion protein was expressed in Pichia pastoris. The affinity of scFv-human serum albumin fusion protein to bind to acetylcholine receptor at the ...

journal_title：Neural regeneration research

authors： Li F,Meng F,Jin Q,Sun C,Li Y,Li H,Jin S

更新日期：2014-04-15 00:00:00

abstract：:Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...

journal_title：Neural regeneration research

authors： Zheng G,Chen X,Xu B,Zhang J,Lv X,Li J,Li F,Hu S,Zhang T,Li Y

更新日期：2013-03-05 00:00:00

abstract：:The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine protein kinase (Akt) and c-Jun N-...

journal_title：Neural regeneration research

authors： Jin M,Yang YW,Cheng WP,Lu JK,Hou SY,Dong XH,Liu SY

更新日期：2015-11-01 00:00:00

abstract：:The three-dimensional (3D) visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there rema...

journal_title：Neural regeneration research

authors： Qi J,Wang WY,Zhong YC,Zhou JM,Luo P,Tang P,He CF,Zhu S,Liu XL,Zhang Y

更新日期：2018-08-01 00:00:00

abstract：:Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...

journal_title：Neural regeneration research

authors： Ding J,He Z,Ruan J,Liu Y,Gong C,Sun S,Chen H

更新日期：2013-02-05 00:00:00

abstract：:We hypothesized that the P2X7 receptor may be the target of isoflurane, so we investigated the roles of the P2X7 receptor and inositol triphosphate receptor in calcium overload and neuronal apoptosis induced by isoflurane in cultured embryonic rat hippocampal neurons. Results showed that isoflurane induced widespread ...

journal_title：Neural regeneration research

authors： Liu H,Dai T,Guo W

更新日期：2013-03-25 00:00:00

abstract：:Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...

journal_title：Neural regeneration research

authors： Zhao YD,Zhang QB,Chen H,Fei XF,Shen YT,Ji XY,Ma JW,Wang AD,Dong J,Lan Q,Huang Q

更新日期：2017-11-01 00:00:00

abstract：:In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...

journal_title：Neural regeneration research

authors： Li Q,Zhai Q,Geng J,Zheng H,Chen F,Kong J,Zhang C

更新日期：2012-08-05 00:00:00

abstract：:This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majori...

journal_title：Neural regeneration research

authors： Wu P,Zeng F,Li YX,Yu BL,Qiu LH,Qin W,Li J,Zhou YM,Liang FR

更新日期：2015-05-01 00:00:00

abstract：:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

journal_title：Neural regeneration research

authors： Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

更新日期：2021-07-01 00:00:00

abstract：:Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model...

journal_title：Neural regeneration research

authors： Gao BY,Sun CC,Xia GH,Zhou ST,Zhang Y,Mao YR,Liu PL,Zheng Y,Zhao D,Li XT,Xu J,Xu DS,Bai YL

更新日期：2020-11-01 00:00:00

abstract：:Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor function. This occurs even when the most meticulous microsurgical techniques or nerve grafts are used. Previous studies had proposed that nerve transfer was more effective than nerve grafting for nerve repair. Our...

journal_title：Neural regeneration research

authors： Wang PJ,Zhang Y,Zhao JJ,Zhou JP,Zuo ZC,Wu BB

更新日期：2017-01-01 00:00:00

abstract：:Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse...

journal_title：Neural regeneration research

authors： Mao HF,Xie J,Chen JQ,Tang CF,Chen W,Zhou BC,Chen R,Qu HL,Wu CZ

更新日期：2017-04-01 00:00:00

abstract：:Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...

journal_title：Neural regeneration research

authors： Pan B,Shi ZJ,Yan JY,Li JH,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extracranial internal carotid artery occlusion. The study included 65 patients with extracranial internal carotid artery occlusion who u...

journal_title：Neural regeneration research

authors： Jiao L,Song G,Hua Y,Ma Y,Chen Y,Wang Y,Ling F

更新日期：2013-08-15 00:00:00