Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke.

abstract：:Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...

journal_title：Neural regeneration research

authors： Jiang H,Xiang Y,Hu X,Cai H

更新日期：2014-08-15 00:00:00

abstract：:Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or ...

journal_title：Neural regeneration research

authors： Xia P,Pan S,Cheng J,Yang M,Qi Z,Hou T,Yang X

更新日期：2014-09-15 00:00:00

abstract：:Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesiz...

journal_title：Neural regeneration research

authors： Vafaee F,Zangiabadi N,Pour FM,Dehghanian F,Asadi-Shekaari M,Afshar HK

更新日期：2012-09-25 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors su...

journal_title：Neural regeneration research

authors： Mathis S,Couratier P,Julian A,Corcia P,Le Masson G

更新日期：2017-02-01 00:00:00

abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

journal_title：Neural regeneration research

authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

更新日期：2016-09-01 00:00:00

abstract：:Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we us...

journal_title：Neural regeneration research

authors： Yang XM,Chen XH,Lu JF,Zhou CM,Han JY,Chen CH

更新日期：2018-03-01 00:00:00

abstract：:The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

journal_title：Neural regeneration research

authors： Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

更新日期：2016-11-01 00:00:00

abstract：:Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was establi...

journal_title：Neural regeneration research

authors： Lv SQ,Wu W

更新日期：2021-08-01 00:00:00

abstract：:Proanthocyanidins have been shown to effectively protect ischemic neurons, but its mechanism remains poorly understood. Ginkgo proanthocyanidins (20, 40, 80 mg/kg) were intraperitoneally administered 1, 24, 48 and 72 hours before reperfusion. Results showed that ginkgo proanthocyanidins could effectively mitigate neur...

journal_title：Neural regeneration research

authors： Cao WL,Huang HB,Fang L,Hu JN,Jin ZM,Wang RW

更新日期：2016-11-01 00:00:00

abstract：:There is long-standing debate about sensate versus non-sensate free microvascular flaps among microsurgeons. The principle of connecting not only the vascular supply, but also sensitive nerves, in free tissue transfer is attractive. However, increased operating time and partial spontaneous innervation led to the commo...

journal_title：Neural regeneration research

authors： Sinis N,Lamia A,Gudrun H,Schoeller T,Werdin F

更新日期：2012-10-15 00:00:00

abstract：:Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

journal_title：Neural regeneration research

authors： Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

更新日期：2016-12-01 00:00:00

abstract：:Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Daw...

journal_title：Neural regeneration research

authors： Lai SM,Gu ZT,Zhao MM,Li XX,Ma YX,Luo L,Liu J

更新日期：2017-10-01 00:00:00

abstract：:The present study quantitatively analyzed intraspinal cerebrospinal fluid flow patterns in 19 normal adults using fast cine phase-contrast magnetic resonance imaging. Results showed increased downward flow velocity and volume compared with upward flow, and the average downward flow volume of intraspinal cerebrospinal ...

journal_title：Neural regeneration research

authors： Yan L,Liu H,Shang H

更新日期：2012-05-25 00:00:00

abstract：:Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment...

journal_title：Neural regeneration research

authors： Liu GY,Jin Y,Zhang Q,Li R

更新日期：2015-06-01 00:00:00

abstract：:For decades, clinicians have developed medications and therapies to alleviate the symptoms of Parkinson's disease, but no treatment currently can slow or even stop the progression of this localized neurodegeneration. Fortunately, sparked by the genetic revolution, stem cell reprogramming research and the advancing cap...

journal_title：Neural regeneration research

authors： Stoddard-Bennett T,Pera RR

更新日期：2020-01-01 00:00:00

abstract：:The Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of ...

journal_title：Neural regeneration research

authors： Cai X,Yang L,Zhou J,Zhu D,Guo Q,Chen Z,Chen S,Zhou L

更新日期：2013-02-25 00:00:00

abstract：:The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...

journal_title：Neural regeneration research

authors： Yuan XN,Liang WD,Zhou FH,Li HT,Zhang LX,Zhang ZQ,Li JJ

更新日期：2019-02-01 00:00:00

abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

journal_title：Neural regeneration research

authors： Tanokashira D,Fukuokaya W,Taguchi A

更新日期：2019-08-01 00:00:00

abstract：:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

journal_title：Neural regeneration research

authors： Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

更新日期：2021-07-01 00:00:00

abstract：:The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepez...

journal_title：Neural regeneration research

authors： Lauterbach EC

更新日期：2016-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the older population, however, the precise cause of the disease is unknown. The neuropathology is characterized by the presence of aggregates formed by amyloid-β (Aβ) peptide and phosphorylated tau; which is accompanied by progressive impairment of memory...

journal_title：Neural regeneration research

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-10-01 00:00:00

abstract：:Following spinal cord ischemia/reperfusion injury, an endogenous damage system is immediately activated and participates in a cascade reaction. It is difficult to interpret dynamic changes in these pathways, but the examination of the transcriptome may provide some information. The transcriptome reflects highly dynami...

journal_title：Neural regeneration research

authors： Qi ZP,Xia P,Hou TT,Li DY,Zheng CJ,Yang XY

更新日期：2016-03-01 00:00:00

abstract：:To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case o...

journal_title：Neural regeneration research

authors： Seo Y,Shin MH,Kim SG,Kim JH

更新日期：2013-01-15 00:00:00

abstract：:This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...

journal_title：Neural regeneration research

authors： Kwon YH,Kang KW,Lee NK,Son SM

更新日期：2016-01-01 00:00:00

abstract：:Many hypotheses exist regarding the mechanism underlying delayed encephalopathy after acute carbon monoxide poisoning (DEACMP), including the inflammation and immune-mediated damage hypothesis and the cellular apoptosis and direct neuronal toxicity hypothesis; however, no existing hypothesis provides a satisfactory ex...

journal_title：Neural regeneration research

authors： Huang YQ,Peng ZR,Huang FL,Yang AL

更新日期：2020-12-01 00:00:00

abstract：:Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using mole...

journal_title：Neural regeneration research

authors： Wang X,Yang Y,Jia M,Ma C,Wang M,Che L,Yang Y,Wu J

更新日期：2013-01-05 00:00:00

abstract：:The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm ...

journal_title：Neural regeneration research

authors： Lu YJ,Cai XW,Zhang GF,Huang Y,Tang CZ,Shan BC,Cui SY,Chen JQ,Qu SS,Zhong Z,Lai XS,Steiner GZ

更新日期：2017-07-01 00:00:00

abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...

journal_title：Neural regeneration research

authors： Xu Q,Liu T,Chen S,Gao Y,Wang J,Qiao L,Liu J

更新日期：2012-06-25 00:00:00

abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...

journal_title：Neural regeneration research

authors： Dong S,Tong X,Li J,Huang C,Hu C,Jiao H,Gu Y

更新日期：2013-12-05 00:00:00

abstract：:Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

journal_title：Neural regeneration research

authors： Shultz RB,Zhong Y

更新日期：2017-05-01 00:00:00