Abstract:
:The present study involved a questionnaire survey of 156 mothers that gave birth to children with neural tube defects or had a history of pregnancy resulting in children with neural tube defects (case group) and 156 control mothers with concurrent healthy children (control group) as well as detection of mitochondrial membrane transporter protein gene [uncoupling protein 2 (UCP2)] polymorphism. The maternal UCP2 3' untranslated region (UTR) D/D genotype and D allele frequency were significantly higher in the case group compared with the control group (odds ratio (OR) 3.233; 95% confidence interval (CI) 1.103-9.476; P = 0.040; OR: 3.484; 95% CI: for neural tube defects 2.109-5.753; P < 0.001). Univariate and multivariate logistic regression analysis of risk factors for neural tube defects showed that a maternal UCP2 3' UTR D/D genotype was negatively interacted with the mothers' consumption of frequent fresh fruit and vegetables (S = 0.007), positively interacted with the mothers' frequency of germinated potato consumption (S = 2.15) and positively interacted with the mothers' body mass index (S = 3.50). These findings suggest that maternal UCP2 3' UTR gene polymorphism, pregnancy time, consumption of germinated potatoes and body mass index are associated with an increased risk for neural tube defects in children from mothers living in Shanxi province, China. Moreover, there is an apparent gene-environment interaction involved in the development of neural tube defects in offspring.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Liu Z,Xie J,Luo T,Zhang T,Zhao X,Zhao H,Li Pdoi
10.3969/j.issn.1673-5374.2011.06.010subject
Has Abstractpub_date
2012-02-25 00:00:00pages
463-9issue
6eissn
1673-5374issn
1876-7958pii
NRR-7-463journal_volume
7pub_type
杂志文章abstract::Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.08.008
更新日期:2013-03-15 00:00:00
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abstract::[This corrects the article DOI: 10.4103/1673-5374.245480]. ...
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pub_type: 杂志文章,已发布勘误
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更新日期:2019-06-01 00:00:00
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更新日期:2013-06-15 00:00:00
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