Abstract：
:Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following nervous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regeneration rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engineered "living scaffolds", which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in preclinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Struzyna LA,Harris JP,Katiyar KS,Chen HI,Cullen DKdoi
10.4103/1673-5374.156943subject
Has Abstractpub_date
2015-05-01 00:00:00pages
679-85issue
5eissn
1673-5374issn
1876-7958pii
NRR-10-679journal_volume
10pub_type
杂志文章abstract：:Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Daw...
journal_title：Neural regeneration research
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abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...
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abstract：:This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence ...
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abstract：:Three-dimensional (3D) histology utilizes tissue clearing techniques to turn intact tissues transparent, allowing rapid interrogation of tissue architecture in three dimensions. In this article, we summarized the available tissue clearing methods and classified them according to their physicochemical principles of ope...
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pub_type： 杂志文章,评审
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
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更新日期：2016-02-01 00:00:00
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更新日期：2012-06-05 00:00:00
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更新日期：2017-06-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.07.009
更新日期：2013-03-05 00:00:00
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更新日期：2016-09-01 00:00:00
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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更新日期：2021-07-01 00:00:00
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journal_title：Neural regeneration research
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doi：10.3969/j.issn.1673-5374.2012.34.011
更新日期：2012-12-05 00:00:00
abstract：:Single-chain variable domain fragment (scFv) 637 is an antigen-specific scFv of myasthenia gravis. In this study, scFv and human serum albumin genes were conjugated and the fusion protein was expressed in Pichia pastoris. The affinity of scFv-human serum albumin fusion protein to bind to acetylcholine receptor at the ...
journal_title：Neural regeneration research
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