Abstract:
:Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhao Y,Li J,Tang Q,Gao J,Chen C,Jing L,Zhang P,Li Sdoi
10.4103/1673-5374.130060subject
Has Abstractpub_date
2014-03-01 00:00:00pages
463-73issue
5eissn
1673-5374issn
1876-7958pii
NRR-9-463journal_volume
9pub_type
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