Abstract:
:Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Lei T,Li H,Fang Z,Lin J,Wang S,Xiao L,Yang F,Liu X,Zhang J,Huang Z,Liao Wdoi
10.4103/1673-5374.128218subject
Has Abstractpub_date
2014-02-01 00:00:00pages
260-7issue
3eissn
1673-5374issn
1876-7958pii
NRR-9-260journal_volume
9pub_type
杂志文章abstract::Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.11.002
更新日期:2013-04-15 00:00:00
abstract::The influence of duration of immobilization and postoperative sensory re-education on the final outcome after reconstruction of digital nerves with direct suture or muscle-in-vein conduits was investigated. The final sensory outcome of 35 patients with 41 digital nerve injuries, who either underwent a direct suture (D...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.169638
更新日期:2016-02-01 00:00:00
abstract::Endothelial progenitor cells secrete a variety of growth factors that inhibit inflammation, promote angiogenesis and exert neuroprotective effects. Therefore, in this study, we investigated whether endothelial progenitor cell-conditioned medium might have therapeutic effectiveness for the treatment of spinal cord inju...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.232484
更新日期:2018-05-01 00:00:00
abstract::Human umbilical mesenchymal stem cells from Wharton's jelly of the umbilical cord were induced to differentiate into oligodendrocyte precursor-like cells in vitro. Oligodendrocyte precursor cells were transplanted into contused rat spinal cords. Immunofluorescence double staining indicated that transplanted cells surv...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.10.003
更新日期:2013-04-05 00:00:00
abstract::Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.139465
更新日期:2014-08-01 00:00:00
abstract::In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.155433
更新日期:2015-04-01 00:00:00
abstract::Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in prolines, a...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.284980
更新日期:2020-12-01 00:00:00
abstract::Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit (ENC), engineered fibroblast conduit (EFC), and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibr...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.215265
更新日期:2017-09-01 00:00:00
abstract::The γ-aminobutyric acid neurotransmitter in the spinal cord dorsal horn plays an important role in pain modulation through primary afferent-mediated presynaptic inhibition. The weakening of γ-aminobutyric acid-mediated presynaptic inhibition may be an important cause of neuropathic pain. γ-aminobutyric acid-mediated p...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.32.002
更新日期:2012-11-15 00:00:00
abstract::Spinal cord injury is a major cause of disability with devastating neurological outcomes and limited therapeutic opportunities, even though there are thousands of publications on spinal cord injury annually. There are two major types of spinal cord injury, transaction of the spinal cord and spinal cord contusion. Both...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.131591
更新日期:2014-04-15 00:00:00
abstract::Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positi...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.01.010
更新日期:2012-01-05 00:00:00
abstract::Acacetin (5,7-dihydroxy-4'-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an effect on inflammatory corpuscle 3 (NLRP3) after cerebral ischemia-reperfusion injury has not been fully determined. This s...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.247465
更新日期:2019-04-01 00:00:00
abstract::In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.272619
更新日期:2020-07-01 00:00:00
abstract::The mechanism involved in neural regeneration after spinal cord injury is unclear. The myelin-derived protein Nogo-A, which is specific to the central nervous system, has been identified to negatively affect the cytoskeleton and growth program of axotomized neurons. Studies have shown that Nogo-A exerts immediate and ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.152375
更新日期:2015-02-01 00:00:00
abstract::Schwann cells and neurotrophin-3 play an important role in neural regeneration, but the secretion of neurotrophin-3 from Schwann cells is limited, and exogenous neurotrophin-3 is inactived easily in vivo. In this study, we have transfected neurotrophin-3 into Schwann cells cultured in vitro using nanoparticle liposome...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.14.002
更新日期:2013-05-15 00:00:00
abstract::Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone II...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.200810
更新日期:2017-02-01 00:00:00
abstract::The present study showed that the latency of rats moving on a vertical grid was significantly prolonged, and the number of rats sliding down from the declined plane was increased remarkably, in rotenone-induced Parkinson's disease model rats compared with control rats. The moving latency recovered to normal levels, bu...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.05.001
更新日期:2012-02-15 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in the older population, however, the precise cause of the disease is unknown. The neuropathology is characterized by the presence of aggregates formed by amyloid-β (Aβ) peptide and phosphorylated tau; which is accompanied by progressive impairment of memory...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.238606
更新日期:2018-10-01 00:00:00
abstract::Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.251191
更新日期:2019-07-01 00:00:00
abstract::Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced brain injury. This study was designed to determine whether olive leaf extract can inhibit lead-induced ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.22.001
更新日期:2013-08-05 00:00:00
abstract::This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuou...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.03.008
更新日期:2012-01-25 00:00:00
abstract::Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using mole...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.01.005
更新日期:2013-01-05 00:00:00
abstract::Single-chain variable domain fragment (scFv) 637 is an antigen-specific scFv of myasthenia gravis. In this study, scFv and human serum albumin genes were conjugated and the fusion protein was expressed in Pichia pastoris. The affinity of scFv-human serum albumin fusion protein to bind to acetylcholine receptor at the ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.131611
更新日期:2014-04-15 00:00:00
abstract::Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.230294
更新日期:2018-04-01 00:00:00
abstract::Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold mater...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.243701
更新日期:2019-01-01 00:00:00
abstract::The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.306095
更新日期:2021-09-01 00:00:00
abstract::A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.286972
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA: INCLUSION CRITERIA:(a) peer-reviewed publ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.33.009
更新日期:2012-11-25 00:00:00
abstract::The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.187018
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To analyze international research trends in hepatic encephalopathy and examine the role of neuroelectrophysiology and neuroimaging in diagnosis of hepatic encephalopathy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on hepatic encephalopathy published during 2002-2011 retrieved from Web of ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.34.011
更新日期:2012-12-05 00:00:00