Rabs and axonal regeneration.

Abstract:

:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed.

journal_name

Neural Regen Res

authors

Yong CQY,Tang BL

doi

10.4103/1673-5374.247422

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

566-569

issue

4

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2019_14_4_566_247422

journal_volume

14

pub_type

杂志文章,评审
  • Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage.

    abstract::Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.29.001

    authors: Chen G,Hu T,Li Q,Li J,Jia Y,Wang Z

    更新日期:2013-10-15 00:00:00

  • Discovery of nigral dopaminergic neurogenesis in adult mice.

    abstract::Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.184449

    authors: Morrison BE

    更新日期:2016-06-01 00:00:00

  • Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries.

    abstract:OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.130094

    authors: He B,Zhu Z,Zhu Q,Zhou X,Zheng C,Li P,Zhu S,Liu X,Zhu J

    更新日期:2014-03-15 00:00:00

  • Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy.

    abstract::There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.33.003

    authors: Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

    更新日期:2013-11-25 00:00:00

  • Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion.

    abstract::Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expre...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.31.001

    authors: Xin H,Liang W,Mang J,Lin L,Guo N,Zhang F,Xu Z

    更新日期:2012-11-05 00:00:00

  • Influence of RNA interference on the mitochondrial subcellular localization of alpha-synuclein and on the formation of Lewy body-like inclusions in the cytoplasm of human embryonic kidney 293 cells induced by the overexpression of alpha-synuclein.

    abstract::The specific and effective α-synuclein RNA interference (RNAi) plasmids, and the α-synuclein-pEGFP recombinant plasmids were co-transfected into human embryonic kidney 293 (HEK293) cells using the lipofectamine method. Using an inverted fluorescence microscope, α-synuclein proteins were observed to aggregate in the cy...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.02.001

    authors: Chen T,Liao X,Wen G,Deng Y,Guo M,Long Z,Ouyang F

    更新日期:2012-01-15 00:00:00

  • Strategies for myelin regeneration: lessons learned from development.

    abstract::Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understandi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.137586

    authors: Bhatt A,Fan LW,Pang Y

    更新日期:2014-07-15 00:00:00

  • Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy.

    abstract::Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbil...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.05.002

    authors: Yao L,He C,Zhao Y,Wang J,Tang M,Li J,Wu Y,Ao L,Hu X

    更新日期:2013-02-15 00:00:00

  • How does the motor relearning program improve neurological function of brain ischemia monkeys?

    abstract::The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injure...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.16.001

    authors: Yin Y,Gu Z,Pan L,Gan L,Qin D,Yang B,Guo J,Hu X,Wang T,Feng Z

    更新日期:2013-06-05 00:00:00

  • Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction.

    abstract::Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone II...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.200810

    authors: Yang YD,Yu X,Wang XM,Mu XH,He F

    更新日期:2017-02-01 00:00:00

  • Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation: A diffusion tensor imaging study.

    abstract::We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolle...

    journal_title:Neural regeneration research

    pub_type:

    doi:10.3969/j.issn.1673-5374.2013.05.012

    authors: Lee AY,Jang SH,Yeo SS,Lee E,Cho YW,Son SM

    更新日期:2013-02-15 00:00:00

  • Factors affecting directional migration of bone marrow mesenchymal stem cells to the injured spinal cord.

    abstract::Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.141804

    authors: Xia P,Pan S,Cheng J,Yang M,Qi Z,Hou T,Yang X

    更新日期:2014-09-15 00:00:00

  • Acrylamide inhibits nerve sprouting induced by botulinum toxin type A.

    abstract::Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.139479

    authors: Jiang H,Xiang Y,Hu X,Cai H

    更新日期:2014-08-15 00:00:00

  • Research progress in hepatic encephalopathy in recent 10 years: A Web of Science-based literature analysis.

    abstract:OBJECTIVE:To analyze international research trends in hepatic encephalopathy and examine the role of neuroelectrophysiology and neuroimaging in diagnosis of hepatic encephalopathy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on hepatic encephalopathy published during 2002-2011 retrieved from Web of ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.34.011

    authors: Li N

    更新日期:2012-12-05 00:00:00

  • Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects.

    abstract::Schwann cells and neurotrophin-3 play an important role in neural regeneration, but the secretion of neurotrophin-3 from Schwann cells is limited, and exogenous neurotrophin-3 is inactived easily in vivo. In this study, we have transfected neurotrophin-3 into Schwann cells cultured in vitro using nanoparticle liposome...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.14.002

    authors: Zong H,Zhao H,Zhao Y,Jia J,Yang L,Ma C,Zhang Y,Dong Y

    更新日期:2013-05-15 00:00:00

  • Corrigendum: Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis.

    abstract::[This corrects the article DOI: 10.4103/1673-5374.245480]. ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,已发布勘误

    doi:10.4103/1673-5374.250633

    authors:

    更新日期:2019-06-01 00:00:00

  • Association of G-protein coupled purinergic receptor P2Y2 with ischemic stroke in a Han Chinese population of North China.

    abstract::The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.245472

    authors: Yuan LY,He ZY,Li L,Wang YZ

    更新日期:2019-03-01 00:00:00

  • DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after 125I radioactive seed implantation.

    abstract::Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.228758

    authors: Cao X,Fang L,Cui CY,Gao S,Wang TW

    更新日期:2018-03-01 00:00:00

  • Neuroprotective effects of a ketogenic diet in combination with exogenous ketone salts following acute spinal cord injury.

    abstract::We have previously shown that induction of ketosis by ketogenic diet (KD) conveyed neuroprotection following spinal cord injury in rodent models, however, clinical translation may be limited by the slow raise of ketone levels when applying KD in the acute post-injury period. Thus we investigated the use of exogenous k...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.280327

    authors: Tan BT,Jiang H,Moulson AJ,Wu XL,Wang WC,Liu J,Plunet WT,Tetzlaff W

    更新日期:2020-10-01 00:00:00

  • Galanin and its receptor system promote the repair of injured sciatic nerves in diabetic rats.

    abstract::Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.191228

    authors: Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

    更新日期:2016-09-01 00:00:00

  • Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage.

    abstract::In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endot...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.08.006

    authors: Wang R,Hao D,Shi W,Pu J,Wang Z

    更新日期:2012-03-15 00:00:00

  • Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus.

    abstract::Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In t...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.131577

    authors: Liu J,Li J,Yang Y,Wang X,Zhang Z,Zhang L

    更新日期:2014-04-01 00:00:00

  • Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury.

    abstract::Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.266914

    authors: Zhao JJ,Liu ZW,Wang B,Huang TQ,Guo D,Zhao YL,Song JN

    更新日期:2020-04-01 00:00:00

  • Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis.

    abstract::Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction, the nicotinic acetylcholine receptor. Other varia...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.290880

    authors: Barrantes FJ

    更新日期:2021-02-01 00:00:00

  • Extracellular vesicles in the diagnosis and treatment of central nervous system diseases.

    abstract::Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substan...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.266908

    authors: Shaimardanova AA,Solovyeva VV,Chulpanova DS,James V,Kitaeva KV,Rizvanov AA

    更新日期:2020-04-01 00:00:00

  • Changes in the blood-nerve barrier after sciatic nerve cold injury: indications supporting early treatment.

    abstract::Severe edema in the endoneurium can occur after non-freezing cold injury to the peripheral nerve, which suggests damage to the blood-nerve barrier. To determine the effects of cold injury on the blood-nerve barrier, the sciatic nerve on one side of Wistar rats was treated with low temperatures (3-5°C) for 2 hours. The...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.153690

    authors: Li H,Jia JP,Xu M,Zhang L

    更新日期:2015-03-01 00:00:00

  • Effects of neural stem cell transplantation on the motor function of rats with contusion spinal cord injuries: a meta-analysis.

    abstract:Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.266915

    authors: Qian K,Xu TY,Wang X,Ma T,Zhang KX,Yang K,Qian TD,Shi J,Li LX,Wang Z

    更新日期:2020-04-01 00:00:00

  • Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain.

    abstract::A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.224374

    authors: Kim J,Im HI,Moon C

    更新日期:2018-01-01 00:00:00

  • Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury.

    abstract::Cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy. The recovery of erectile function following radical prostatectomy remains challenging. Our previous studies found that injecting adipose-derived stem cells (ADSCs) into the cavernosa could repair the damaged cavernous ner...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.264464

    authors: Yang M,Sun JY,Ying CC,Wang Y,Guo YL

    更新日期:2020-01-01 00:00:00

  • Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia.

    abstract::In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham con...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.184490

    authors: Yoo DY,Yoo KY,Park JH,Kwon HJ,Jung HY,Kim JW,Choi GM,Moon SM,Kim DW,Yoon YS,Won MH,Hwang IK

    更新日期:2016-06-01 00:00:00