Abstract:
:Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are located. Accordingly, the optimal microenvironment for inducing stem cell differentiation is a hot topic. EGb761 is extracted from the leaves of the Ginkgo biloba tree. It is used worldwide and is becoming one of the focuses of stem cell research. Studies have shown that EGb761 can antagonize oxygen free radicals, stabilize cell membranes, promote neurogenesis and synaptogenesis, increase the level of brain-derived neurotrophic factors, and replicate the environment required during the differentiation of stem cells into nerve cells. This offers the possibility of using EGb761 to induce the differentiation of stem cells, facilitating stem cell transplantation. To provide a comprehensive reference for the future application of EGb761 in stem cell therapy, we reviewed studies investigating the influence of EGb761 on stem cells. These started with the composition and neuropharmacology of EGb761, and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial microenvironment for stem cell transplantation.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Ren C,Ji YQ,Liu H,Wang Z,Wang JH,Zhang CY,Guan LN,Yin PYdoi
10.4103/1673-5374.251191subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1152-1157issue
7eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2019_14_7_1152_251191journal_volume
14pub_type
杂志文章abstract::Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pa...
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.194722
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.180753
更新日期:2016-04-01 00:00:00
abstract::Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties. We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury. In this study, rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1, 7, a...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.189197
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pub_type: 杂志文章,评审
doi:10.4103/1673-5374.262571
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.26.001
更新日期:2013-09-15 00:00:00
abstract::The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepez...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.194708
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.4103/1673-5374.128250
更新日期:2014-02-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.141804
更新日期:2014-09-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.245472
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.08.008
更新日期:2013-03-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
abstract::In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham con...
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doi:10.4103/1673-5374.184490
更新日期:2016-06-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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更新日期:2012-07-05 00:00:00
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更新日期:2013-11-05 00:00:00
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pub_type: 杂志文章,评审
doi:10.4103/1673-5374.200794
更新日期:2017-02-01 00:00:00