Abstract:
:Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all the secondary injury mechanisms, the inflammatory response is the major contributor and results in expansion of the lesion and further loss of neurologic function. Meanwhile, the inflammation directly and indirectly dominates the outcomes of SCI, including not only pain and motor dysfunction, but also preventingneuronal regeneration. Microglia and macrophages play very important roles in secondary injury. Microglia reside in spinal parenchyma and survey the microenvironment through the signals of injury or infection. Macrophages are derived from monocytes recruited to injured sites from the peripheral circulation. Activated resident microglia and monocyte-derived macrophages induce and magnify immune and inflammatory responses not only by means of their secretory moleculesand phagocytosis, but also through their influence on astrocytes, oligodendrocytes and demyelination. In this review, we focus on the roles of microglia and macrophages in secondary injury and how they contribute to the sequelae of SCI.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhou X,He X,Ren Ydoi
10.4103/1673-5374.143423subject
Has Abstractpub_date
2014-10-15 00:00:00pages
1787-95issue
20eissn
1673-5374issn
1876-7958pii
NRR-9-1787journal_volume
9pub_type
杂志文章,评审abstract::White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...
journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.191220
更新日期:2016-09-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.179032
更新日期:2016-03-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.189197
更新日期:2016-08-01 00:00:00
abstract::Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer's disease cell model. swAPP695-HEK293 cells were treated with 0, 0.5, 1, 2, 5, and 10 μM curcumin for ...
journal_title:Neural regeneration research
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doi:10.4103/1673-5374.255979
更新日期:2019-09-01 00:00:00
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.268903
更新日期:2020-05-01 00:00:00
abstract::Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...
journal_title:Neural regeneration research
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doi:10.4103/1673-5374.191228
更新日期:2016-09-01 00:00:00
abstract::In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham con...
journal_title:Neural regeneration research
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doi:10.4103/1673-5374.184490
更新日期:2016-06-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.197146
更新日期:2016-12-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.17.004
更新日期:2012-06-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:Neural regeneration research
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更新日期:2019-02-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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更新日期:2013-01-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.147929
更新日期:2014-12-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00