听力与言语-语言病理学

行为科学

医学伦理学

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  • Sequential histological changes in the liver of medaka exposed to methylazoxymethaol acetate.

    abstract::We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2020-0033

    authors: Hoshikawa Y,Furukawa S,Irie K,Kimura M,Takeuchi K,Sugiyama A

    更新日期:2020-10-01 00:00:00

  • Patient-derived xenograft (PDX) models: characteristics and points to consider for the process of establishment.

    abstract::Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1293/tox.2020-0007

    authors: Fujii E,Kato A,Suzuki M

    更新日期:2020-07-01 00:00:00

  • Impact of altered dietary calcium-phosphorus ratio caused by high-phosphorus diets in a rat chronic kidney disease (CKD) model created by partial ligation of the renal arteries.

    abstract::This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2019-0086

    authors: Watanabe A,Koizumi T,Horikawa T,Sano Y,Uki H,Miyajima K,Kemuriyama N,Anzai R,Iwata H,Anzai T,Nakagawa K,Nakae D

    更新日期:2020-04-01 00:00:00

  • Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats.

    abstract::Intratracheal instillation is the introduction of a substance directly into the trachea. Intratracheal instillation has been used to investigate the lung toxicity of several chemicals and requires the suspension or dissolution of test material in a vehicle for even dispersal throughout the lung. Importantly, the toxic...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2019-0060

    authors: Numano T,Morioka M,Higuchi H,Uda K,Sugiyama T,Hagiwara T,Doi Y,Imai N,Kawabe M,Mera Y,Tamano S

    更新日期:2020-01-01 00:00:00

  • Brain findings associated with risperidone in rhesus monkeys: magnetic resonance imaging and pathology perspectives.

    abstract::Brain changes associated with risperidone, a dopamine-2/serotonin-2 receptor antagonist, have been documented in rats and humans, but not in nonhuman primates. This study characterized brain changes associated with risperidone in nonhuman primates. Rhesus monkeys were orally administered risperidone in a dose-escalati...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2019-0004

    authors: Fernandez G,Kuruvilla S,Hines CDG,Poignant F,Marr J,Forest T,Briscoe R

    更新日期:2019-10-01 00:00:00

  • Immunohistochemical characterization of oxidative stress in the lungs of rats exposed to the humidifier disinfectant polyhexamethylene guanidine hydrochloride.

    abstract::Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2019-0049

    authors: Lee YH,Seo DS,Lee MJ,Cha HG

    更新日期:2019-10-01 00:00:00

  • Effects of food restriction on the expression of genes related to acetaminophen-induced liver toxicity in rats.

    abstract::It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2018-0009

    authors: Tsuchiya Y,Sakai H,Hirata A,Yanai T

    更新日期:2018-10-01 00:00:00

  • Improved fixation of the whole bodies of fish by a double-fixation method with formalin solution and Bouin's fluid or Davidson's fluid.

    abstract::To prevent fixation defects or artifacts in the whole bodies of fish caused by conventional fixatives, such as formalin solution, Bouin's fluid (BF), and Davidson's fluid (DF), the optimal fixatives and fixing method were examined. An improved method of fixing the whole bodies of fish was examined that makes use of a ...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2018-0001

    authors: Miki M,Ohishi N,Nakamura E,Furumi A,Mizuhashi F

    更新日期:2018-07-01 00:00:00

  • Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.

    abstract::Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2017-0064

    authors: Kemmochi Y,Ohta T,Motohashi Y,Kaneshige A,Katsumi S,Kakimoto K,Yasui Y,Anagawa-Nakamura A,Toyoda K,Taniai-Riya E,Takahashi A,Shoda T,Yamada T

    更新日期:2018-04-01 00:00:00

  • Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.

    abstract::The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1293/tox.31.1S

    authors: Brändli-Baiocco A,Balme E,Bruder M,Chandra S,Hellmann J,Hoenerhoff MJ,Kambara T,Landes C,Lenz B,Mense M,Rittinghausen S,Satoh H,Schorsch F,Seeliger F,Tanaka T,Tsuchitani M,Wojcinski Z,Rosol TJ

    更新日期:2018-01-01 00:00:00

  • Spontaneous hypertrophic cardiomyopathy in a cynomolgus macaque (Macaca fascicularis).

    abstract::The term cardiomyopathy is used to describe heart disease resulting from an abnormality in the myocardium. It is rare in cynomolgus macaques (Macaca fascicularis). Here, we report a case of hypertrophic cardiomyopathy in an 11-year-old male cynomolgus macaque. Macroscopically, the interventricular septum (IVS) and the...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.2017-0027

    authors: Konishi S,Kotera T,Koga M,Ueda M

    更新日期:2018-01-01 00:00:00

  • Sustained renal inflammation following 2 weeks of inhalation of occupationally relevant levels of zinc oxide nanoparticles in Sprague Dawley rats.

    abstract::Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4....

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2017-0025

    authors: Chien CC,Yan YH,Juan HT,Cheng TJ,Liao JB,Lee HP,Wang JS

    更新日期:2017-10-01 00:00:00

  • Spontaneous nephroblastoma with striated muscle differentiation in an F344 rat.

    abstract::An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.2017-0004

    authors: Tanaka N,Izawa T,Yamate J,Kuwamura M

    更新日期:2017-07-01 00:00:00

  • A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy.

    abstract::Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in re...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1293/tox.2017-0006

    authors: Seely JC

    更新日期:2017-04-01 00:00:00

  • Acute alloxan renal toxicity in the rat initially causes degeneration of thick ascending limbs of Henle.

    abstract::Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2016-0035

    authors: Terayama Y,Kodama Y,Matsuura T,Ozaki K

    更新日期:2017-01-01 00:00:00

  • Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling.

    abstract::Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (ERK1/2) signaling pl...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2016-0032

    authors: Chen H,Wang Q,Shi D,Yao D,Zhang L,Xiong J,Xu B

    更新日期:2016-10-01 00:00:00

  • Comparative histopathology of the estrous or menstrual cycle in laboratory animals.

    abstract::Accurate analysis of female reproductive toxicity requires a thorough understanding the differences in and specifics of estrous or menstrual cycles between laboratory animals. There are some species differences such as the time of sex maturation, the length of the estrous or menstrual cycle, the length of the luteal p...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1293/tox.2016-0021

    authors: Sato J,Nasu M,Tsuchitani M

    更新日期:2016-07-01 00:00:00

  • Transient effects of empty liposomes on hepatic macrophage populations in rats.

    abstract::Liposomes have been used as a vehicle for encapsulating chemicals or toxins in toxicological studies. We investigated the transient effects of empty liposomes on hepatic macrophages by applying a single intravenous injection at a dose of 10 ml/kg body weight in 6-week-old male F344 rats. One day after injection, the n...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2015-0082

    authors: Pervin M,Golbar HM,Bondoc A,Izawa T,Kuwamura M,Yamate J

    更新日期:2016-04-01 00:00:00

  • Spontaneous extraskeletal osteosarcoma with various histological growth patterns in the abdominal wall of an ICR mouse.

    abstract::Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, th...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.2015-0046

    authors: Ito T,Katoh Y,Shimada Y,Ohnuma-Koyama A,Takahashi N,Kuwahara M,Harada T

    更新日期:2016-01-01 00:00:00

  • Predictive modes of action of pesticides in uterine adenocarcinoma development in rats.

    abstract::Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2015-0026

    authors: Yoshida M,Inoue K,Takahashi M

    更新日期:2015-10-01 00:00:00

  • Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog.

    abstract::A single mass was found on the left submandibular salivary gland at necropsy of a 15-month-old male commercially bred laboratory Beagle dog from a control dose group from a repeat toxicity study. Microscopically, the mass was composed of a well-demarcated area of coagulative necrosis surrounded and separated from the ...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.2015-0018

    authors: Mukaratirwa S,Petterino C,Bradley A

    更新日期:2015-07-01 00:00:00

  • Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium.

    abstract::Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports ...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2014-0061

    authors: Sonoda J,Seki Y,Hakura A,Hosokawa S

    更新日期:2015-04-01 00:00:00

  • Lipopolysaccharide induces expression of collagen VI in the rat lung.

    abstract::The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2014-0053

    authors: Okawa S,Unuma K,Yamada A,Aki T,Uemura K

    更新日期:2015-01-01 00:00:00

  • Absorption, distribution and pathological injury in mice due to ricin poisoning via the alimentary pathway.

    abstract::The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2013-0049

    authors: Dong N,Li Z,Li Q,Wu J,Jia P,Wang Y,Gao Z,Han G,Wu Y,Zhou J,Shan J,Li H,Wei W

    更新日期:2014-04-01 00:00:00

  • Spleen-specific development of germinal centers in rats treated with antithyroid drugs.

    abstract::The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2013-0012

    authors: Fukui M,Fukui N,Sakai K,Hasegawa Y,Nagasaki S,Shibata S,Araki S,Isobe M,Hisada S

    更新日期:2013-12-01 00:00:00

  • Evaluation of the modifying effect of inhalation of mainstream cigarette smoke on mouse bladder carcinogenesis.

    abstract::Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.2013-0039

    authors: Kato M,Wei M,Yamano S,Fujioka M,Kakehashi A,Wanibuchi H

    更新日期:2013-12-01 00:00:00

  • Corneal mineralization in wistar hannover rats.

    abstract::We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.26.275

    authors: Hashimoto S,Doi T,Wako Y,Sato J,Wada S,Tsuchitani M

    更新日期:2013-09-01 00:00:00

  • Spontaneous Rhabdomyosarcoma in a Common Marmoset ( Callithrix jacchus ).

    abstract::The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset w...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.26.187

    authors: Tochitani T,Matsumoto I,Hoshino K,Toyosawa K,Kouchi M,Koujitani T,Kimura J,Funabashi H

    更新日期:2013-06-01 00:00:00

  • Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats.

    abstract::Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.26.61

    authors: Yoshizawa K,Emoto Y,Kinoshita Y,Kimura A,Uehara N,Yuri T,Shikata N,Tsubura A

    更新日期:2013-03-01 00:00:00

  • Splenic hemangiosarcoma in a young sprague-dawley rat.

    abstract::The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.25.273

    authors: Shiraki K,Ono M,Kajikawa S,Takeuchi A,Murakami Y,Oishi Y,Matsumoto M

    更新日期:2012-12-01 00:00:00

  • Histopathological changes in the pancreas from a spontaneous hyperglycemic cynomolgus monkey.

    abstract::Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.25.215

    authors: Fujisawa H,Zhang Z,Sun W,Huang M,Kobayashi J,Yasuda H,Kinoshita Y,Ando R,Tamura K

    更新日期:2012-09-01 00:00:00

  • Dysferlin and animal models for dysferlinopathy.

    abstract::Dysferlin (DYSF) is involved in the membrane-repair process, in the intracellular vesicle system and in T-tubule development in skeletal muscle. It interacts with mitsugumin 53, annexins, caveolin-3, AHNAK, affixin, S100A10, calpain-3, tubulin and dihydropyridine receptor. Limb-girdle muscular dystrophy 2B (LGMD2B) an...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.25.135

    authors: Kobayashi K,Izawa T,Kuwamura M,Yamate J

    更新日期:2012-06-01 00:00:00

  • Age Difference in Morphology and Immunohistology inthe Thymus and Spleen in Crl:CD (SD) Rats.

    abstract::We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age....

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.25.55

    authors: Kodama R,Okazaki T,Sato T,Iwashige S,Tanigawa Y,Fujishima J,Moriyama A,Yamashita N,Sasaki Y,Yoshikawa T,Kamimura Y,Maeda H

    更新日期:2012-03-01 00:00:00

  • High susceptibility to zymbal gland and intestinal carcinogenesis in diabetic Otsuka long-evans Tokushima Fatty rats.

    abstract::Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and ...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.24.187

    authors: Hafez E,Takahashi T,Ogawa H,Sato M,Nakai T,Takasu C,Uehara H,Izumi K

    更新日期:2011-12-01 00:00:00

  • Immunohistochemical Expressions of Main PGE(2) Biosynthesis-related Enzymes and PGE(2) Receptor in Rat Nephrogenesis.

    abstract::Endogenous prostaglandin (PG) E(2) plays important roles in renal homeostasis. Immunoexpressions of PGE(2) biosynthesis-related enzymes, cyclooxygenase (COX)-2 and microsomal PGE(2) synthetase (mPGES)-1 and EP4 (a PGE(2) receptor), were investigated in renal development. Kidney tissues were obtained from fetuses on ge...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.24.257

    authors: Yamamoto E,Izawa T,Kuwamura M,Yamate J

    更新日期:2011-12-01 00:00:00

  • No Involvement of Lysophosphatidic Acid Receptor-3 in Cell Migration of Mouse Lung Tumor Cells Stimulatedby 12-O-Tetradecanoylphorbol-13-acetate.

    abstract::The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is invo...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.24.183

    authors: Okumura M,Kato K,Fukui R,Fukushima N,Tsujiuchi T

    更新日期:2011-09-01 00:00:00

  • Pathology in Continuous Infusion Studies in Rodents and Non-Rodents and ITO (Infusion Technology Organisation)-Recommended Protocol for Tissue Sampling and Terminology for Procedure-Related Lesions.

    abstract::Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of majo...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.24.113

    authors: Weber K,Mowat V,Hartmann E,Razinger T,Chevalier HJ,Blumbach K,Green OP,Kaiser S,Corney S,Jackson A,Casadesus A

    更新日期:2011-06-01 00:00:00

  • Pulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesis.

    abstract::Chronic lung injury resulting from a variety of different causes is frequently associated with the develop ment of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents pl...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.24.9

    authors: Yoshida T,Ohnuma A,Horiuchi H,Harada T

    更新日期:2011-03-01 00:00:00

  • International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.

    abstract::The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type nonclinical toxicology studies. Trainees optimally should undertake a scientific curriculum of at least 5 years at an accredited...

    journal_title:Journal of toxicologic pathology

    pub_type: 杂志文章

    doi:10.1293/tox.23.171

    authors: Bolon B,Barale-Thomas E,Bradley A,Ettlin RA,Franchi CA,George C,Giusti AM,Hall R,Jacobsen M,Konishi Y,Ledieu D,Morton D,Park JH,Scudamore CL,Tsuda H,Vijayasarathi SK,Wijnands MV

    更新日期:2010-09-01 00:00:00

  • A cardiac rhabdomyoma in a Guinea pig.

    abstract::A guinea pig (9-week-old) that had been placed in a control group for a pharmacological test was found to have a single nodule on the surface of the right ventricular wall. In a transverse section of the heart after fixation, a whitish mass was found that extended from the subendocardium to the subepicardium of the ri...

    journal_title:Journal of toxicologic pathology

    pub_type:

    doi:10.1293/tox.23.107

    authors: Kobayashi T,Kobayashi Y,Fukuda U,Ozeki Y,Takahashi M,Fujioka S,Fuchikami J

    更新日期:2010-06-01 00:00:00

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