听力与言语-语言病理学

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医学伦理学

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  • A practical, one-clinic visit protocol for pharmacokinetic profile generation with the ADVATE® myPKFiT® dosing tool in severe hemophilia A subjects.

    abstract::Standard pharmacokinetic (PK) assessments are demanding for persons with hemophilia A, requiring a 72hr washout and 5-11 timed blood samples. A no-washout, single-clinic visit, sparse sampling population PK (PPK) protocol is an attractive alternative. Here, we compared PK parameters obtained with a traditional washout...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验

    doi:10.1055/a-1376-0970

    authors: Blanchette V,Zunino L,Grassmann V,Barnes C,Carcao M,Curtain J,Jackson SC,Khoo L,Komrska V,Lillicrap D,Morfini M,Romanova G,Stephens D,Zapotocka E,Rand ML,Blatny J

    更新日期:2021-01-27 00:00:00

  • Pharmacodynamic profile in East Asian patients with ACS treated with prasugrel standard-dose v de-escalation strategy: a randomized A-MATCH trial.

    abstract::Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验

    doi:10.1055/a-1346-3300

    authors: Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

    更新日期:2021-01-05 00:00:00

  • Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics.

    abstract::The multimeric plasma glycoprotein von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand Disease. By employing cone and platelet aggregometry...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/a-1344-4405

    authors: Huck V,Chen PC,Xu ER,Tischer A,Klemm U,Aponte-Santamaría C,Mess C,Obser T,Kutzki F,König G,Denis C,Gräter F,Wilmanns M,Auton M,Schneider SW,Schneppenheim R,Hennig J,Brehm MA

    更新日期:2020-12-31 00:00:00

  • Stroke and Thromboembolism in Warfarin-Treated Patients with Atrial Fibrillation: Comparing the CHA2DS2-VASc and GARFIELD-AF Risk Scores.

    abstract:BACKGROUND: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA2DS2-VASc score is largely validated and recommended by most guidelines. The GARFIELD-AF Stroke score has been proposed as an alternative risk score. METHODS: We analyzed warfarin-treated patients fro...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/a-1333-4448

    authors: Proietti M,Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Lip GYH

    更新日期:2020-12-09 00:00:00

  • On-Ticagrelor Platelet Reactivity and Clinical Outcome in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome.

    abstract:BACKGROUND: A strong association between on-thienopyridine platelet reactivity (PR) and the risk of both thrombotic and bleeding events in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) has been demonstrated. However, no study has analyzed the relationship between on-ticagrel...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/a-1326-5110

    authors: Laine M,Panagides V,Frère C,Cuisset T,Gouarne C,Jouve B,Lemesle G,Paganelli F,Alessi MC,Mancini J,Bonello L

    更新日期:2020-12-01 00:00:00

  • The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease.

    abstract::East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1718729

    authors: Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

    更新日期:2020-11-10 00:00:00

  • Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small-Interfering RNA.

    abstract::Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the c...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1715442

    authors: de Jong A,Dirven RJ,Boender J,Atiq F,Anvar SY,Leebeek FWG,van Vlijmen BJM,Eikenboom J

    更新日期:2020-11-01 00:00:00

  • PAK Membrane Translocation and Phosphorylation Regulate Platelet Aggregation Downstream of Gi and G12/13 Pathways.

    abstract::Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1714745

    authors: Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

    更新日期:2020-11-01 00:00:00

  • Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.

    abstract::Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III H...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1717114

    authors: Schmitt C,Adamkewicz JI,Xu J,Petry C,Catalani O,Young G,Negrier C,Callaghan MU,Levy GG

    更新日期:2020-10-21 00:00:00

  • Clinical Characteristics and Outcomes of Women Presenting with Venous Thromboembolism during Pregnancy and Postpartum Period: Findings from the RIETE Registry.

    abstract::Although venous thromboembolism (VTE) is a leading cause of maternal mortality, there is a paucity of real-world clinical data on clinical presentation and management of VTE during pregnancy and postpartum period. Using data from the international RIETE (Registro Informatizado Enfermedad Trombo Embólica) registry, pre...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1714211

    authors: Elgendy IY,Fogerty A,Blanco-Molina Á,Rosa V,Schellong S,Skride A,Portillo J,Lopez-Miguel P,Monreal M,Weinberg I

    更新日期:2020-10-01 00:00:00

  • Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke.

    abstract:BACKGROUND AND AIM: Previous studies indicated that the HDAC3 and HDAC9 genes play critical roles in atherosclerosis and ischemic stroke (IS). The purpose of this study was to investigate the association of combined single-nucleotide polymorphisms in the HDAC3 and HDAC9 genes with the susceptibility to IS. METHODS: A ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1717116

    authors: Chiou HY,Bai CH,Lien LM,Hu CJ,Jeng JS,Tang SC,Lin HJ,Hsieh YC

    更新日期:2020-09-22 00:00:00

  • The Effect of Age on von Willebrand Factor and Bleeding Symptoms in von Willebrand Disease.

    abstract::von Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessar...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1713636

    authors: Seaman CD,Ragni MV

    更新日期:2020-08-01 00:00:00

  • Thr90Ser Mutation in Antithrombin is Associated with Recurrent Thrombosis in a Heterozygous Carrier.

    abstract::Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1710590

    authors: Lu Y,Villoutreix BO,Biswas I,Ding Q,Wang X,Rezaie AR

    更新日期:2020-07-01 00:00:00

  • Function of Large and Small Platelets Differs, Depending on Extracellular Calcium Availability and Type of Inductor.

    abstract::It is widely anticipated that large platelets are more reactive than small platelets. This was mainly shown in Ca2+-poor media albeit extracellular Ca2+ is utilized by platelets for activation. We determined the impact of extracellular Ca2+ on functional differences between large and small platelets in response to thr...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1712447

    authors: Handtke S,Wesche J,Palankar R,Greinacher A,Thiele T

    更新日期:2020-07-01 00:00:00

  • Differential Osteoprotegerin Kinetics after Stimulation with Desmopressin and Lipopolysaccharides In Vivo.

    abstract::Osteoprotegerin (OPG) regulates bone metabolism by reducing the activation of osteoclasts, but may also be involved in blood vessel calcification and atherosclerosis. Within endothelial cells OPG is stored in Weibel-Palade bodies (WPBs). Blood kinetics of OPG are essentially unknown. We aimed to assess these using two...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1712448

    authors: Buchtele N,Kovacevic KD,Brostjan C,Schwameis M,Hayden H,Derhaschnig U,Firbas C,Jilma B,Schoergenhofer C

    更新日期:2020-07-01 00:00:00

  • Differentiation of Patients with Symptomatic Low von Willebrand Factor from Those with Asymptomatic Low von Willebrand Factor.

    abstract:BACKGROUND: Accurate diagnosis of symptomatic low von Willebrand factor (VWF) remains a major challenge in von Willebrand disease (VWD). However, present tests do not adequately take into account flow forces that, at very high shear rates, reveal a weakness in the VWF-platelet glycoprotein glycoprotein Ib bond in norma...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1709525

    authors: Grabowski EF,Van Cott EM,Bornikova L,Boyle DC,Silva RL

    更新日期:2020-05-01 00:00:00

  • Pretransplant Genetic Susceptibility: Clinical Relevance in Transplant-Associated Thrombotic Microangiopathy.

    abstract::Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical out...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1702225

    authors: Gavriilaki E,Touloumenidou T,Sakellari I,Batsis I,Mallouri D,Psomopoulos F,Tsagiopoulou M,Koutra M,Yannaki E,Papalexandri A,Taylor P,Nikolousis E,Stamouli M,Holbro A,Baltadakis I,Liga M,Spyridonidis A,Tsirigotis P,Cha

    更新日期:2020-04-01 00:00:00

  • Effects of Native Fucosylated Glycosaminoglycan, Its Depolymerized Derivatives on Intrinsic Factor Xase, Coagulation, Thrombosis, and Hemorrhagic Risk.

    abstract::A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata (nHG), mainly branched with Fuc3S4S, exhibited potent anticoagulant activity by intrinsic tenase iXase (FIXa-FVIIIa complex) and antithrombin-dependent factor IIa (FIIa) inhibition, but also had the effects of FXII activation and platele...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1708480

    authors: Zhou L,Gao N,Sun H,Xiao C,Yang L,Lin L,Yin R,Li Z,Zhang H,Ji X,Zhao J

    更新日期:2020-04-01 00:00:00

  • Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis.

    abstract::Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-3402808

    authors: Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

    更新日期:2020-02-01 00:00:00

  • Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding.

    abstract::Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1700517

    authors: Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

    更新日期:2020-01-01 00:00:00

  • High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets.

    abstract:OBJECTIVE: Blood monocyte subsets are emerging as biomarkers of cardiovascular inflammation. However, our understanding of human monocyte heterogeneity and their immunophenotypic features under healthy and inflammatory conditions is still evolving. RATIONALE: In this study, we sought to investigate the immunophenome o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1700871

    authors: Hoffmann J,Fišer K,Liebetrau C,Staubach N,Kost D,Voss S,Heiden AZ,Dörr O,Lipps C,Nef HM,Möllmann H,Hamm CW,Keller T,Troidl C

    更新日期:2020-01-01 00:00:00

  • Particulate Shiga Toxin 2 in Blood is Associated to the Development of Hemolytic Uremic Syndrome in Children.

    abstract::Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections. STEC are confined to the gut resulting in hemorrhagic colitis, whereas Stx are delivered in blood to target kidney and brain, with unc...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-3400301

    authors: Brigotti M,He X,Carnicelli D,Arfilli V,Porcellini E,Galassi E,Tazzari PL,Ricci F,Patfield SA,Testa S,Paglialonga F,Picicco D,Caprioli A,Scavia G,Morabito S,Ardissino G

    更新日期:2020-01-01 00:00:00

  • Single Low Dose of rFVIIa Combined with Antifibrinolytic Agent is a Simple and Safe Treatment for Factor XI-Deficient Patients undergoing Surgery.

    abstract:BACKGROUND: Factor XI (FXI) deficiency is a rare autosomal bleeding disorder. The rarity of spontaneous bleeding and absence of optimal tools to predict the bleeding risk in FXI-deficient patients hamper the standardization of prophylactic treatment enabling them to undergo major surgeries without blood products. OBJE...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1696685

    authors: Salomon O,Budnik I,Avishai E,Tamarin I,Bashari D,Dardik R,Livnat T

    更新日期:2019-12-01 00:00:00

  • Multistate Models: Accurate and Dynamic Methods to Improve Predictions of Thrombotic Risk in Patients with Cancer.

    abstract::Research into cancer-associated thrombosis (CAT) entails managing dynamic data that pose an analytical challenge. Thus, methods that assume proportional hazards to investigate prognosis entail a risk of misinterpreting or overlooking key traits or time-varying effects. We examined the AGAMENON registry, which collects...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0039-1694012

    authors: Carmona-Bayonas A,Jimenez-Fonseca P,Garrido M,Custodio A,Hernandez R,Lacalle A,Cano JM,Aguado G,Martínez de Castro E,Alvarez Manceñido F,Macias I,Visa L,Martín Richard M,Mangas M,Sánchez Cánovas M,Longo F,Iglesias Rey L,

    更新日期:2019-11-01 00:00:00

  • Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.

    abstract:BACKGROUND: Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of these two...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0039-1693740

    authors: Yamakawa K,Gando S,Ogura H,Umemura Y,Kabata D,Shintani A,Shiraishi A,Saitoh D,Fujishima S,Mayumi T,Kushimoto S,Abe T,Shiino Y,Nakada TA,Tarui T,Hifumi T,Otomo Y,Okamoto K,Kotani J,Sakamoto Y,Sasaki J,Shiraishi S

    更新日期:2019-11-01 00:00:00

  • Aspirin and Primary Prevention in Patients with Diabetes-A Critical Evaluation of Available Randomized Trials and Meta-Analyses.

    abstract::Primary prevention of cardiovascular events with aspirin in patients with elevated cardiovascular risk, including diabetics, is currently under intense discussion. Data from meta-analyses suggests that the efficacy of aspirin in these patients is low, whereas there is a significantly increased bleeding tendency. Howev...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1694774

    authors: Schrör K,Kristensen SD,Storey RF,Verheugt FWA

    更新日期:2019-10-01 00:00:00

  • Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.

    abstract::Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1692721

    authors: Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

    更新日期:2019-09-01 00:00:00

  • Antiphospholipid Syndrome in Chronic Thromboembolic Pulmonary Hypertension: A Well-Defined Subgroup of Patients.

    abstract::Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Cli...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1692428

    authors: Jiang X,Du Y,Cheng CY,Denas G,Zhou YP,Wu T,Zhang YX,Han ZY,Pengo V,Jing ZC

    更新日期:2019-09-01 00:00:00

  • Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis.

    abstract::Long noncoding ribonucleic acids (lncRNAs) have been defined as transcripts which are > 200 ribonucleotides in size and are not translated into protein. Recent work has shown that many lncRNAs do have specific molecular functions and biological effects, and are involved in a growing number of diseases, including ather...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1692680

    authors: Holdt LM,Kohlmaier A,Teupser D

    更新日期:2019-08-01 00:00:00

  • Heterogeneity of Macrophages in Atherosclerosis.

    abstract::Atherosclerosis is a prevalent inflammatory condition and a frequent cause of morbidity and mortality worldwide. Macrophages are among the key immune cells driving lesion formation in the arterial wall. They have therefore evolved as potential targets for therapeutic strategies. Understanding of the different macropha...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1692665

    authors: Stremmel C,Stark K,Schulz C

    更新日期:2019-08-01 00:00:00

  • Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

    abstract::Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. To further...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1685453

    authors: Hollerbach A,Müller-Calleja N,Ritter S,Häuser F,Canisius A,Orning C,Jurk K,Lackner KJ

    更新日期:2019-07-01 00:00:00

  • Changes in Oral Anticoagulation Therapy over One Year in 51,000 Atrial Fibrillation Patients at Risk for Stroke: A Practice-Derived Study.

    abstract:BACKGROUND: This study assessed changes in anticoagulation therapy over time in patients with atrial fibrillation (AF). METHODS: Analyses were performed on a claims-based dataset of 4 million health-insured individuals. The study population consisted of patients newly initiating a non-vitamin-K oral anticoagulants (NO...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1683428

    authors: Hohnloser SH,Basic E,Nabauer M

    更新日期:2019-06-01 00:00:00

  • Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis.

    abstract::The mechanisms or host factors involved in septic thrombus or vegetation formation in Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental endocarditis rat model, here we demonstrated that S. aureus HG001-induced vegetation was composed of bacterial floes encased in aggregated p...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1678665

    authors: Hsu CC,Hsu RB,Ohniwa RL,Chen JW,Yuan CT,Chia JS,Jung CJ

    更新日期:2019-05-01 00:00:00

  • PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.

    abstract::Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to significant long-term sequelae. The PREVAPIX-ALL study is an open-label ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-0039-1679938

    authors: O'Brien SH,Li D,Mitchell LG,Hess T,Zee P,Yee DL,Newburger JW,Sung L,Rodriguez V

    更新日期:2019-05-01 00:00:00

  • A Novel Diagnostic and Prognostic Score for Abdominal Aortic Aneurysms Based on D-Dimer and a Comprehensive Analysis of Myeloid Cell Parameters.

    abstract::The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1679939

    authors: Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

    更新日期:2019-05-01 00:00:00

  • Diurnal Variability of On-Treatment Platelet Reactivity in Clopidogrel versus Prasugrel Treated Acute Coronary Syndrome Patients: A Pre-Specified TROPICAL-ACS Sub-Study.

    abstract::Long-term evidence supports a clustering of cardiovascular events in the early morning and smaller mechanistic studies in aspirin-treated patients have shown increased platelet reactivity at the end of the dosing interval. Comparative pharmacodynamic analyses for different adenosine diphosphate (ADP) receptor inhibito...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-0038-1677549

    authors: Freynhofer MK,Hein-Rothweiler R,Haller PM,Aradi D,Dézsi DA,Gross L,Orban M,Trenk D,Geisler T,Huczek Z,Toth-Gayor GG,Massberg S,Huber K,Sibbing D

    更新日期:2019-04-01 00:00:00

  • Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.

    abstract::Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676794

    authors: Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

    更新日期:2019-03-01 00:00:00

  • Hypertrophic Cardiomyopathy in Patients with Atrial Fibrillation: Prevalence and Associated Stroke Risks in a Nationwide Cohort Study.

    abstract:BACKGROUND: There have been no prior nationwide reports on the prevalence of hypertrophic cardiomyopathy (HCM) among patients suffering from atrial fibrillation (AF). It is also unclear how much stroke risk is attributable to HCM compared with other stroke risks in patients with AF. This study assessed the prevalence o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676818

    authors: Jung H,Yang PS,Sung JH,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Lip GYH,Joung B

    更新日期:2019-02-01 00:00:00

  • Recombinant Human Soluble Thrombomodulin in Sepsis-Induced Coagulopathy: An Updated Systematic Review and Meta-Analysis.

    abstract:BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,meta分析

    doi:10.1055/s-0038-1676345

    authors: Yamakawa K,Murao S,Aihara M

    更新日期:2019-01-01 00:00:00

  • Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment.

    abstract::Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676520

    authors: Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

    更新日期:2019-01-01 00:00:00

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