听力与言语-语言病理学

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医学伦理学

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  • Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium.

    abstract::The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease risk. Genome-wide association studies (GWAS) have identified multiple signals in the estrogen receptor 1 (ESR1) region associated with endometriosis and other reproductive traits and diseases....

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa082

    authors: Marla S,Mortlock S,Houshdaran S,Fung J,McKinnon B,Holdsworth-Carson SJ,Girling JE,Rogers PAW,Giudice LC,Montgomery GW

    更新日期:2021-01-22 00:00:00

  • Premature ovarian ageing following heterozygous loss of Senataxin.

    abstract::Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women. Despite the high prevalence of POA, very little is known regarding its genet...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa080

    authors: Subramanian GN,Lavin M,Homer HA

    更新日期:2020-12-18 00:00:00

  • Two human menopausal gonadotrophin (hMG) preparations display different early signaling in vitro.

    abstract::Commercial hMG drugs are marketed for the treatment of infertility and consist of highly purified hormones acting on receptors expressed in target gonadal cells. Menopur® and Meriofert® are combined preparation of FSH and hCG and are compared in vitro herein. To this purpose, the molecular composition of the two drugs...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa070

    authors: Casarini L,Riccetti L,Paradiso E,Benevelli R,Lazzaretti C,Sperduti S,Melli B,Tagliavini S,Varani M,Trenti T,Morini D,Falbo A,Villani MT,Jonas KC,Simoni M

    更新日期:2020-12-10 00:00:00

  • A mouse model reveals the events and underlying regulatory signals during the gonadotrophin-dependent phase of follicle development.

    abstract::During folliculogenesis, the gonadotrophin (GTH)-dependent phase begins at the small antral follicle stage and ends with Graafian follicles. In this study, pregnant mare's serum GTH was used to induce GTH-dependent folliculogenesis in mice, following which the developmental events that follicles undergo, as well as th...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa069

    authors: Chen Y,Wang X,Yang C,Liu Q,Ran Z,Li X,He C

    更新日期:2020-12-10 00:00:00

  • Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts.

    abstract::Early embryonic development is characterized by drastic changes in chromatin structure that affects the accessibility of the chromatin. In human, the chromosome reorganization and its involvement in the first linage segregation are poorly characterized due to the difficulties in obtaining human embryonic material and ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa048

    authors: Yang M,Tao X,Titus S,Zhao T,Scott RT,Seli E

    更新日期:2020-09-01 00:00:00

  • miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome.

    abstract::MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa044

    authors: Jiang L,Huang H,Qian Y,Li Y,Chen X,Di N,Yang D

    更新日期:2020-08-01 00:00:00

  • Potential influence of COVID-19/ACE2 on the female reproductive system.

    abstract::The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章,评审

    doi:10.1093/molehr/gaaa030

    authors: Jing Y,Run-Qian L,Hao-Ran W,Hao-Ran C,Ya-Bin L,Yang G,Fei C

    更新日期:2020-06-01 00:00:00

  • Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs.

    abstract::Zinc dynamics are essential for oocyte meiotic maturation, egg activation, and preimplantation embryo development. During fertilisation and egg activation, the egg releases billions of zinc atoms (Zn2+) in an exocytotic event termed the 'zinc spark'. We hypothesised that this zinc transport and exocytosis is dependent...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaaa017

    authors: Lee HC,Edmonds ME,Duncan FE,O'Halloran TV,Woodruff TK

    更新日期:2020-04-24 00:00:00

  • Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants.

    abstract::Prevention of mitochondrial DNA (mtDNA) diseases may currently be possible using germline nuclear transfer (NT). However, scientific evidence to compare efficiency of different NT techniques to overcome mtDNA diseases is lacking. Here, we performed four types of NT, including first or second polar body transfer (PB1/2...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz062

    authors: Tang M,Guggilla RR,Gansemans Y,Van der Jeught M,Boel A,Popovic M,Stamatiadis P,Ferrer-Buitrago M,Thys V,Van Coster R,Deforce D,De Sutter P,Van Nieuwerburgh F,Heindryckx B

    更新日期:2019-12-01 00:00:00

  • The effect of maternal high-fat/high-sugar diet on offspring oocytes and early embryo development.

    abstract::Observational human data and several lines of animal experimental data indicate that maternal obesity impairs offspring health. Here, we comprehensively tested the model that maternal obesity causes defects in the next three generations of oocytes and embryos. We exposed female F0 mice to a high-fat/high-sugar (HF/HS)...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz049

    authors: Andreas E,Reid M,Zhang W,Moley KH

    更新日期:2019-11-30 00:00:00

  • Ultrastructure and intercellular contact-mediated communication in cultured human early stage follicles exposed to mTORC1 inhibitor.

    abstract::The reproductive lifespan of a woman is determined by the gradual recruitment of quiescent follicles into the growing pool. In humans, ovarian tissue removal from its in vivo environment induces spontaneous activation of resting follicles. Similarly, pharmacological activation of the PI3K/Akt pathway leads to accelera...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz053

    authors: Grosbois J,Vermeersch M,Devos M,Clarke HJ,Demeestere I

    更新日期:2019-11-30 00:00:00

  • Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence.

    abstract::Advanced glycation end products (AGEs) affect the follicular microenvironment. The close relationship between AGEs, proinflammatory cytokine production and activation of the unfolded protein response (UPR), which involves activating transcription factor 4 (ATF4), is crucial for regulation of various cellular functions...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz050

    authors: Takahashi N,Harada M,Azhary JMK,Kunitomi C,Nose E,Terao H,Koike H,Wada-Hiraike O,Hirata T,Hirota Y,Koga K,Fujii T,Osuga Y

    更新日期:2019-11-30 00:00:00

  • Differences in blastomere totipotency in 2-cell mouse embryos are a maternal trait mediated by asymmetric mRNA distribution.

    abstract::It is widely held that the first two blastomeres of mammalian embryos are equally totipotent and that this totipotency belongs to the group of regulative properties. However, this interpretation neglects an important aspect: evidence only came from successful monozygotic twins which can speak only for those pairs of h...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz051

    authors: Casser E,Wdowik S,Israel S,Witten A,Schlatt S,Nordhoff V,Boiani M

    更新日期:2019-11-30 00:00:00

  • Successful reversal of ovarian hyperstimulation syndrome in a mouse model by rapamycin, an mTOR pathway inhibitor.

    abstract::Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening, iatrogenic complication of ovarian stimulation in assisted reproduction technology. This complex syndrome is characterised by enlarged ovaries with multiple corpora luteum, elevated sex steroid hormones in serum and increased capillary permeab...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz033

    authors: Liu W,Zhang C,Wang L,Huang X,Zhang J,He Y,Chen L,Li J

    更新日期:2019-08-01 00:00:00

  • Autophagy regulates abnormal placentation induced by folate deficiency in mice.

    abstract::Folate deficiency has been linked to a wide range of pregnancy disorders. Most research about folate-deficiency has focused on the embryo itself, little attention has been paid to possible effects on the placenta. According to our results, the morphology of the placenta, endocrine function, and the expression of genes...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz022

    authors: Yin X,Gao R,Geng Y,Chen X,Liu X,Mu X,Ding Y,Wang Y,He J

    更新日期:2019-06-06 00:00:00

  • Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids.

    abstract::Oxidative stress is a major aetiology in many pathologies, including that of male infertility. Recent evidence in somatic cells has linked oxidative stress to the induction of a novel cell death modality termed ferroptosis. However, the induction of this iron-regulated, caspase-independent cell death pathway has never...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz015

    authors: Bromfield EG,Walters JLH,Cafe SL,Bernstein IR,Stanger SJ,Anderson AL,Aitken RJ,McLaughlin EA,Dun MD,Gadella BM,Nixon B

    更新日期:2019-05-01 00:00:00

  • MicroRNA mimics that target the placental renin-angiotensin system inhibit trophoblast proliferation.

    abstract::In early gestation, the human placental renin-angiotensin system (RAS) is upregulated and plays a role in placental development. Among other functions, signalling through the angiotensin II type 1 receptor (AT1R) initiates proliferation. Many microRNAs (miRNAs) targeting placental RAS mRNAs are downregulated at this t...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz010

    authors: Arthurs AL,Lumbers ER,Pringle KG

    更新日期:2019-04-01 00:00:00

  • Temporal patterns of gene regulation and upstream regulators contributing to major developmental transitions during Rhesus macaque preimplantation development.

    abstract::The preimplantation period of life in mammals encompasses a tremendous amount of restructuring and remodeling of the embryonic genome and reprogramming of gene expression. These vast changes support metabolic activation and cellular processes that drive early cleavage divisions and enable the creation of the earliest ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaz001

    authors: Schall PZ,Ruebel ML,Midic U,VandeVoort CA,Latham KE

    更新日期:2019-03-01 00:00:00

  • Transcriptome analysis of rhesus monkey failed-to-mature oocytes: deficiencies in transcriptional regulation and cytoplasmic maturation of the oocyte mRNA population.

    abstract:STUDY QUESTION:Which different pathways and functions are altered in rhesus monkey oocytes that fail to mature after an ovulatory stimulus? SUMMARY ANSWER:Failed to mature (FTM) oocytes complete a large portion of the transition in transcriptome composition associated with normal maturation, but also manifest numerous...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gay032

    authors: Ruebel ML,Schall PZ,Midic U,Vincent KA,Goheen B,VandeVoort CA,Latham KE

    更新日期:2018-10-01 00:00:00

  • Retrospective analysis: reproducibility of interblastomere differences of mRNA expression in 2-cell stage mouse embryos is remarkably poor due to combinatorial mechanisms of blastomere diversification.

    abstract:STUDY QUESTION:What is the prevalence, reproducibility and biological significance of transcriptomic differences between sister blastomeres of the mouse 2-cell embryo? SUMMARY ANSWER:Sister 2-cell stage blastomeres are distinguishable from each other by mRNA analysis, attesting to the fact that differentiation starts ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gay021

    authors: Casser E,Israel S,Schlatt S,Nordhoff V,Boiani M

    更新日期:2018-07-01 00:00:00

  • Spermatogonial behavior in marmoset: a new generation, their kinetics and niche.

    abstract:STUDY QUESTION:Could a more detailed evaluation of marmoset spermatogonial morphology, kinetics and niches using high-resolution light microscopy (HRLM) lead to new findings? SUMMARY ANSWER:Three subtypes of marmoset undifferentiated spermatogonia, which were not evenly distributed in terms of number and position alon...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gay017

    authors: Caldeira-Brant AL,Eras-Garcia L,Alves-Freitas D,Almeida FRCL,Chiarini-Garcia H

    更新日期:2018-06-01 00:00:00

  • Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.

    abstract:STUDY QUESTION:What is the association between placental formyl peptide receptor 2 (FPR2) and trophoblast and endothelial functions in pregnancies affected by foetal growth restriction (FGR)? SUMMARY ANSWER:Reduced FPR2 placental expression in idiopathic FGR results in significantly altered trophoblast differentiation...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax067

    authors: Lappas M,McCracken S,McKelvey K,Lim R,James J,Roberts CT,Fournier T,Alfaidy N,Powell KL,Borg AJ,Morris JM,Leaw B,Singh H,Ebeling PR,Wallace EM,Parry LJ,Dimitriadis E,Murthi P

    更新日期:2018-02-01 00:00:00

  • Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro?

    abstract:STUDY QUESTION:Can enzymatically dispersed testicular cells from adult men reassemble into seminiferous cord-like structures in vitro? SUMMARY ANSWER:Adult human testicular somatic cells reassembled into testicular cord-like structures via dynamic interactions of Sertoli and peritubular cells. WHAT IS KNOWN ALREADY:I...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax063

    authors: Mincheva M,Sandhowe-Klaverkamp R,Wistuba J,Redmann K,Stukenborg JB,Kliesch S,Schlatt S

    更新日期:2018-02-01 00:00:00

  • Zona pellucida-binding protein 2 (ZPBP2) and several proteins containing BX7B motifs in human sperm may have hyaluronic acid binding or recognition properties.

    abstract:STUDY QUESTION:Are there novel hyaladherins in human sperm? SUMMARY ANSWER:Zona pellucida-binding protein 2 (ZPBP2), containing a Link-like hyaluronic acid (HA)-binding domain, and several other proteins containing BX7B motifs, such as ADAM32 and Midkine, may be novel hyaladherins with HA-binding properties. WHAT IS ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax053

    authors: Torabi F,Bogle OA,Estanyol JM,Oliva R,Miller D

    更新日期:2017-12-01 00:00:00

  • The acceptability of stem cell-based fertility treatments for different indications.

    abstract:STUDY QUESTION:What is the acceptability of using stem cell-based fertility treatments (SCFT) for different indications according to gynaecologists and the general public? SUMMARY ANSWER:The majority of gynaecologists and the general public accept SCFT for the indications female or male infertility in young heterosexu...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax027

    authors: Hendriks S,Dancet EAF,Vliegenthart R,Repping S

    更新日期:2017-12-01 00:00:00

  • Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.

    abstract:STUDY QUESTION:Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER:Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY:Completion of an acrosome reac...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax044

    authors: Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

    更新日期:2017-10-01 00:00:00

  • A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes.

    abstract:STUDY QUESTION:Does A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion cells? SUMMARY ANSWER:A20 is a nuclear factor-kappa B (NF-κB) responsive gene that acts as a negative regulator of NF-κB-induced expression of pro-labour mediators. WHAT IS KNOWN ALREADY:Infl...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax041

    authors: Lappas M

    更新日期:2017-09-01 00:00:00

  • A pre-in vitro maturation medium containing cumulus oocyte complex ligand-receptor signaling molecules maintains meiotic arrest, supports the cumulus oocyte complex and improves oocyte developmental competence.

    abstract:STUDY QUESTION:Can a pre-in vitro maturation (pre-IVM) medium containing signaling molecules rather than chemical/pharmaceutical agents, sustain meiotic arrest and improve developmental competence of in vitro matured oocytes in CF1 outbred mice? SUMMARY ANSWER:A short 2 h period of pre-IVM prevents spontaneous meiotic...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax032

    authors: Santiquet NW,Greene AF,Becker J,Barfield JP,Schoolcraft WB,Krisher RL

    更新日期:2017-09-01 00:00:00

  • Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis.

    abstract:STUDY QUESTION:Is oxidative stress associated with the A disintegrin and metalloproteases (ADAM) metallopeptidase domain 17 (ADAM17)/Notch signalling pathway and fibrosis in the development of endometriosis? SUMMARY ANSWER:Oxidative stress is correlated with hyperactivation of the ADAM17/Notch signalling pathway and a...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax028

    authors: González-Foruria I,Santulli P,Chouzenoux S,Carmona F,Chapron C,Batteux F

    更新日期:2017-07-01 00:00:00

  • hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells.

    abstract:STUDY QUESTION:How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? SUMMARY ANSWER:hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and tra...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax015

    authors: Tapia-Pizarro A,Archiles S,Argandoña F,Valencia C,Zavaleta K,Cecilia Johnson M,González-Ramos R,Devoto L

    更新日期:2017-06-01 00:00:00

  • Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents.

    abstract:STUDY QUESTION:Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)? SUMMARY ANSWER:The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between the normally clustered ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax012

    authors: Lottrup G,Belling K,Leffers H,Nielsen JE,Dalgaard MD,Juul A,Skakkebæk NE,Brunak S,Rajpert-De Meyts E

    更新日期:2017-05-01 00:00:00

  • Angiogenic properties of endometrial mesenchymal stromal cells in endothelial co-culture: an in vitro model of endometriosis.

    abstract:Study Question:Can endometrial mesenchymal stromal cells (E-MSCs) differentiate into endothelial cells in an in vitro co-culture system with human umbilical vein endothelial cells (HUVECs)? Summary Answer:E-MSCs can acquire endothelial markers and function in a direct co-culture system with HUVECs. What is Known Alre...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gax006

    authors: Canosa S,Moggio A,Brossa A,Pittatore G,Marchino GL,Leoncini S,Benedetto C,Revelli A,Bussolati B

    更新日期:2017-03-01 00:00:00

  • Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus, improves sperm motility and fertilization in different mammalian species.

    abstract:STUDY QUESTION:Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER:We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in ...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw075

    authors: Martinez G,Hograindleur JP,Voisin S,Abi Nahed R,Abd El Aziz TM,Escoffier J,Bessonnat J,Fovet CM,De Waard M,Hennebicq S,Aucagne V,Ray PF,Schmitt E,Bulet P,Arnoult C

    更新日期:2017-02-10 00:00:00

  • Improved cryotolerance and developmental potential of in vitro and in vivo matured mouse oocytes by supplementing with a glutathione donor prior to vitrification.

    abstract:STUDY QUESTION:Can supplementation of media with a glutathione (GSH) donor, glutathione ethyl ester (GEE), prior to vitrification protect the mouse oocyte from oxidative damage and critical changes in redox homeostasis, and thereby improve cryotolerance? SUMMARY ANSWER:GEE supplementation supported redox regulation, r...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw059

    authors: Trapphoff T,Heiligentag M,Simon J,Staubach N,Seidel T,Otte K,Fröhlich T,Arnold GJ,Eichenlaub-Ritter U

    更新日期:2016-12-01 00:00:00

  • A dominant negative mutation at the ATP binding domain of AMHR2 is associated with a defective anti-Müllerian hormone signaling pathway.

    abstract:STUDY QUESTION:Does a heterozygous mutation in AMHR2, identified in whole-exome sequencings (WES) of patients with primary ovarian insufficiency (POI), cause a defect in anti-Müllerian hormone (AMH) signaling? SUMMARY ANSWER:The I209N mutation at the adenosine triphosphate binding domain of AMHR2 exerts dominant negat...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw040

    authors: Li L,Zhou X,Wang X,Wang J,Zhang W,Wang B,Cao Y,Kee K

    更新日期:2016-09-01 00:00:00

  • Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence.

    abstract:STUDY QUESTION:Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING:Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY:Shifts in socioeconomic norms are resulting in l...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw038

    authors: Molinari E,Bar H,Pyle AM,Patrizio P

    更新日期:2016-08-01 00:00:00

  • Developmental origins of inflammatory and immune diseases.

    abstract::Epidemiological and experimental animal studies show that suboptimal environments in fetal and neonatal life exert a profound influence on physiological function and risk of diseases in adult life. The concepts of the 'developmental programming' and Developmental Origins of Health and Diseases (DOHaD) have become well...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章,评审

    doi:10.1093/molehr/gaw036

    authors: Chen T,Liu HX,Yan HY,Wu DM,Ping J

    更新日期:2016-08-01 00:00:00

  • Isolation and gene expression analysis of single potential human spermatogonial stem cells.

    abstract:STUDY HYPOTHESIS:It is possible to isolate pure populations of single potential human spermatogonial stem cells without somatic contamination for down-stream applications, for example cell culture and gene expression analysis. STUDY FINDING:We isolated pure populations of single potential human spermatogonial stem cel...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw006

    authors: von Kopylow K,Schulze W,Salzbrunn A,Spiess AN

    更新日期:2016-04-01 00:00:00

  • Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice.

    abstract:STUDY HYPOTHESIS:What factors in mouse oocytes are involved in the ageing-related decline in oocyte quality? STUDY FINDING:The maternal effect gene Mater is involved in ageing-related oocyte quality decline in mice. WHAT IS KNOWN ALREADY:Premature loss of centromere cohesion is a hallmark of ageing-related oocyte qua...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw001

    authors: Lu YQ,He XC,Zheng P

    更新日期:2016-04-01 00:00:00

  • Female human pluripotent stem cells rapidly lose X chromosome inactivation marks and progress to a skewed methylation pattern during culture.

    abstract:STUDY HYPOTHESIS:Does a preferential X chromosome inactivation (XCI) pattern exist in female human pluripotent stem cells (hPSCs) and does the pattern change during long-term culture or upon differentiation? STUDY FINDING:We identified two independent phenomena that lead to aberrant XCI patterns in female hPSC: a rapi...

    journal_title:Molecular human reproduction

    pub_type: 杂志文章

    doi:10.1093/molehr/gaw004

    authors: Geens M,Seriola A,Barbé L,Santalo J,Veiga A,Dée K,Van Haute L,Sermon K,Spits C

    更新日期:2016-04-01 00:00:00

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